Citation: Sheng Biao WAN, Jun FENG, Feng Ming CHU, Zong Ru GUO. Synthesis of a Novel Series of S-Alkyl Thiobenzoate Compounds as Farnesyltransferase Inhibitors[J]. Chinese Chemical Letters, ;2005, 16(2): 151-154. shu

Synthesis of a Novel Series of S-Alkyl Thiobenzoate Compounds as Farnesyltransferase Inhibitors

Department of Medicinal Chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050

Received Date: 17 December 2003

Fund Project: This work was supported by National Basic Research Program (973 Program:G1998051102).

S-akyl thiobenzoate compounds were designed as famesyltransferase (FTase) inhibitors.An effective synthetic method was explored. The structures of the target compounds were elucidated by NMR spectral and elemental analysis.
- S-Akyl thiobenzoate compounds,
- benzodiazepine,
- farnesyltransferase.
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