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Citation: Zhi-Hua Zhou, Xiao Zhang, Yong-Fu Huang, Kai-Hong Chen, Liang-Nian He. Synthesis of α-hydroxy ketones by copper(I)-catalyzed hydration of propargylic alcohols: CO₂ as a cocatalyst under atmospheric pressure[J]. Chinese Journal of Catalysis, ;2019, 40(9): 1345-1351. doi: S1872-2067(19)63313-9 shu

Synthesis of α-hydroxy ketones by copper(I)-catalyzed hydration of propargylic alcohols: CO₂ as a cocatalyst under atmospheric pressure

a State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China;
b Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin 300071, China

Received Date: 16 December 2018

Fund Project: This work was supported by National Natural Science Foundation of China (21672119), and China Postdoctoral Science Foundation (2018M641624).

Inexpensive and efficient Cu(I) catalysis is reported for the synthesis of α-hydroxy ketones from propargylic alcohols, CO₂, and water via tandem carboxylative cyclization and nucleophilic addition reaction. Notably, hydration of propargylic alcohols can be carried out smoothly under atmospheric CO₂ pressure, generating a series of α-hydroxy ketones efficiently and selectively. This strategy shows great potential for the preparation of valuable α-hydroxy ketones by using CO₂ as a crucial cocatalyst under mild conditions.
- Copper catalysis,
- Propargylic alcohols,
- Hydration,
- α-Hydroxy ketones,
- Carbon dioxide,
- Cocatalyst
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Synthesis of α-hydroxy ketones by copper(I)-catalyzed hydration of propargylic alcohols: CO2 as a cocatalyst under atmospheric pressure

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通讯作者: 陈斌, bchen63@163.com

Synthesis of α-hydroxy ketones by copper(I)-catalyzed hydration of propargylic alcohols: CO₂ as a cocatalyst under atmospheric pressure