Citation: Chen Zhichao, Zhang Hong, Zhou Shufeng, Cui Xiuling. K₂S₂O₈-Initiated Cascade Cyclization of 2-Alkynylnitriles with Sodium Sulfinates: Access to Fused Cyclopenta[gh]phenanthridines[J]. Chinese Journal of Organic Chemistry, ;2020, 40(11): 3866-3872. doi: 10.6023/cjoc202007005 shu

K₂S₂O₈-Initiated Cascade Cyclization of 2-Alkynylnitriles with Sodium Sulfinates: Access to Fused Cyclopenta[gh]phenanthridines

a.
College of Chemical Engineering, Huaqiao University, Xiamen, Fujian 361021
b.
Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen, Fujian 361021

Corresponding author: Zhou Shufeng, szhou@hqu.edu.cn Cui Xiuling, cuixl@hqu.edu.cn
Received Date: 1 July 2020
Revised Date: 30 July 2020
Available Online: 11 August 2020
Fund Project: the Programme of Introducing Talents of Discipline to Universities 111计划，No.BC2018061the National Natural Science Foundation of China 21572072Project supported by the National Natural Science Foundation of China (No. 21572072) and the Programme of Introducing Talents of Discipline to Universities (111 Project, No. BC 2018061)

Figures(2)

A convenient K₂S₂O₈-initiated radical cascade cyclization for the construction of 4-sulfonated cyclopenta[gh]-phenanthridines from 2-alkynylnitriles and sodium sulfinates has been explored under metal-free conditions. This protocol features mild conditions, good functional group tolerance and broad substrate scope. A variety of potentially bioactive 4-sulfonated cyclopenta[gh]phenanthridines were facilely synthesized via direct annulation.
- 2-alkynylnitriles,
- sodium sulfinate,
- 4-sulfonated cyclopenta[gh]phenanthridine,
- radical cyclization cascade
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K2S2O8-Initiated Cascade Cyclization of 2-Alkynylnitriles with Sodium Sulfinates: Access to Fused Cyclopenta[gh]phenanthridines

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通讯作者: 陈斌, bchen63@163.com

K₂S₂O₈-Initiated Cascade Cyclization of 2-Alkynylnitriles with Sodium Sulfinates: Access to Fused Cyclopenta[gh]phenanthridines