Supramolecular Self-Assembly of Dioxyphenylene Bridged Ureidopyrimidinone Derivatives
Supramolecular polymers (SPs) are dynamic materials constructed from monomeric units via reversible non-covalent interactions.[1-5] In recent years, many interesting SPs have been constructed by different non-covalent interactions, including multiple hydrogen bonds, [6-8] π-π interaction,  metal-ligand coordination, [10-12] halogen bond,  host-guest interaction, [14-21] or a combination of them. For example, Liu and co-workers reported a supramolecular ternary polymer fabricated by cucurbituril and cyclodextrin. Li, Zhao and co-workers reported a very interesting hydrogen bonding-driven supramolecular alternate block copolymers which could be tuned by ion-pair binding. Huang and co-workers reported a series of SPs formed by orthogonal self-assembly based on metal-ligand and host-guest interactions. Ureidopyrimidinone (UPy), which is a self-complementary quadruple hydrogen bonding unit reported by Meijer and co-workers,  is a widely used supramolecular polymerization building block on account of its high binding constant (Kdimer > 107 L•mol-1 in CHCl3). Since then, an increasing number of functional SPs have been constructed from UPy.[26-33] In recent years, our group[34-36] has also been working on constructing various UPy-based supramolecular complexes.
As mentioned above, π-π interaction is also an important non-covalent interaction besides hydrogen bonding in supramolecular chemistry. Interestingly, the UPy unit can not only form dimer via quadruple hydrogen bonding but also can undergo π-π stacking behavior. More recently, we reported a UPy-based supramolecular polymerization system, in which supramolecular polymerization of different monomers could be regulated by introducing π-π interaction to the monomer. In that work, the strength of the π-π interaction depends on the orientation and the size of the aromatic groups, which localized at the central of the spacer of the ditopic UPy monomer. Herein, we aim to take a step forward to investigate the impact of spacer length on the supramolecular polymerization of dioxyphenylene bridged ditopic UPys. To this end, three ditopic UPy derivatives M1~M3 were prepared, the only difference of which is the spacer length between two UPy units (Figure 1). By studying this interesting model, we would like to have an insight into the relationship between molecular structure and supramolecular polymerization, which is important to produce tailor-made SPs with functional properties.
2. Results and discussion
The synthesis of M1~M3 is straightforward (Scheme 1). The preparation of M2 and M3 is according to our previous report.[38-39] Coupling of the ditopic amine compound 1a with 1, 1'-carbonyldiimidazole (CDI) activated alkylsubstituted pyrimidinone 2 resulted in the targeted UPy monomer M1, which was fully characterized by 1H NMR, 13C NMR and HR-MS.
Ring-chain equilibrium is an important supramolecular polymerization mechanism, which shows that linear SP species are in equilibrium with their cyclic monomers or oligomers in one system. During the polymerization process, there exists a critical polymerization concentration (CPC), below which the cyclic species, for example, cyclic monomers or cyclic dimers, are predominant. But above CPC, the linear SPs are the main products in the system. Previously, we[39, 41-42] have studied the ring-chain mechanism by incorporating functional group into the ditopic UPy monomers. In this study, the supramolecular polymerization of M1~M3 also follows ring-chain mechanism. Herein, M1 forms cyclic dimer while both M2 and M3 form cyclic monomers below CPC and SPs above CPC.
The supramolecular polymerization behaviors of M1~M3 were firstly studied by concentration-dependent 1H NMR. As shown from Figure 2, the characteristic amide proton signals located in the down field region (H1, H2 and H3; between δ 9 and 14), indicating all the UPy units from M1~M3 exist in dimerization form via quadruple hydrogen bonding. Figure 2a shows the concentration-varied 1H NMR spectra of M1. At low concentration (8 mmol•L-1), two sets of peaks appeared, represent the cyclic dimer and the linear polymer respectively. Due to the short spacer of M1 (n＝1), cyclic dimers should be the smallest species below CPC. As the concentration increased, the peaks representing cyclic dimers gradually disappeared and only one set of peaks remained, which was corresponding to linear SPs. Moreover, the CPC of M1 was calculated based on H1e by plotting the concentration of cyclic monomer versus the total monomer concentration. Therefore, a CPC of 5 mmol•L-1 for M1 was calculated (Figure 3).
The 1H NMR spectra of M2 showed a concise picture with only one set of peaks until the concentration increased to 192 mmol•L-1 (Figure 2b), indicating that it's not easy for M2 to undergo a ring-opening polymerization process. With the increase of the concentration, a new set of peaks representing the linear SPs appeared and their intensity increased gradually. This is because the spacer in M2 is long enough to form a cyclic monomer, which generates a π-π interaction between the dimerized UPy plane and the dioxyphenylene group. The additional π-π interaction greatly stabilizes the quadruple hydrogen bonded cyclic monomer structure, which makes ring-opening of M2 much more difficult. During the ring-opening supramolecular polymerization process, H2c and H2e displayed obvious downfield shifts (from δ 11.27 to 11.87 for H2c, from δ 6.39 to 6.69 for H2e), reflecting the loss of shielding effect between the dioxyphenylene group and the dimerized UPy motif. Meanwhile, the signals of H2a and H2d moved a little to upfield upon ring-opening, suggesting that these protons are located at the edge of the phenylene ring in the cyclic structure. Notably, all proton signals in M2 became broad at high concentration, revealing the formation of large molecular weight SPs. A CPC value of 189 mmol•L-1 for M2 was calculated based on H2e (Figure 3).
What will happen if we further increase the length of the spacer? To clarify this problem, the molecule M3 with n＝3 was designed and synthesized. 1H NMR experiments showed that M3 is neither as difficult as M2 nor as easy as M1 for ring-opening polymerization. The ring-opening of M3 happened at around 64 mmol•L-1 (Figure 2c). There is no doubt that M3 can form cyclic monomers below CPC due to its long spacer. Compared with M2, the distance between the dioxyphenylene group and the dimerized UPy motif in the cyclic form of M3 is longer, leading to a weaker π-π interaction between them and make the cyclic structure of M3 less stable than M2. However, the cyclic monomer structure of M3 is more stable than the cyclic dimer structure of M1 due to the additional π-π interaction, although it is weak. As a result, the CPC of M3 is much less than M2 but higher than M1 and was calculated to be 51 mmol•L-1 (Figure 3).
NOESY of M2 further evidenced its cyclic monomer structure below CPC. As shown from Figure 4, obvious NOE signals between UPy motif (H2a, H2b, and H2c) and phenylene protons (H2e) were observed. Additionally, correlation signals were also observed between 1-ethylpentyl group of the UPy and phenylene protons (H2e). These evidences indicated that M2 formed a cyclic monomer structure via quadruple hydrogen bonding. The NOESY of M3 showed no similar correlation. It might be due to the longer distance between the dioxyphenylene group and the dimerized UPy motif in the cyclic form of M3.
Viscosity measurements is a powerful tool to study supramolecular polymerization. To further investigate the ring-opening supramolecular polymerization process of M1~M3, viscosity measurements were carried out in CHCl3 solution. Double logarithmic plots of specific viscosity versus molecule concentration are shown in Figure 5. At the beginning of the concentration increasing, a slope of ca. 1 was observed for all curves, which is characteristic for non-interacting assemblies with constant size. This suggests the predominance of cyclic species below CPC. Upon increasing the concentration, M1 quickly shows the turning point at 7 mmol•L-1 (CPC) and a moderate rise in the viscosity (k'M1＝1.93). The CPC value is close to the 1H NMR result (5 mmol•L-1). By contrast, M2 showed a turning point at a relatively high concentration and a very steep slope was observed (k'M2＝8.70). The CPC value of M2 measured by viscosity (191 mmol•L-1) is also in accordance with 1H NMR result (189 mmol•L-1). Different from M1 and M2, M3 showed a moderate CPC value of 55 mmol•L-1 and a moderate turning slope (k'M3＝5.71), which is also in agreement with the results from concentration-varied 1H NMR of M3. Subsequently, the viscosity measurements again show the big impact of spacer length on the ring-opening supramolecular polymerization.
Considering that the dioxyphenylene moiety is an electron rich group that can form mechanically interlocked molecules with electron deficient cyclophane, we envisioned what differences would happen in the host-guest complexation of M1~M3 with blue-box[43-44] (also named as CBPQT4+). Notably, we have demonstrated that the ethylpentyl UPy motif could thread into the blue-box. The host-guest complexation of M1~M3 with blue-box in mixed CHCl3/CH3CN solvent was investigated. Interestingly, M3+CBPQT4+ exhibited red color (Figure 6), indicating the existence of host-guest complexation and formation of a hydrogen bonded catenane, which was verified in our previous report. However, neither M1 nor M2 showed any evidence of complexation with CBPQT4+, resulting in a colorless solution with white precipitate after several days even heating to 50 ℃. The reason for M1 should be due to the short spacer, which has a very poor binding ability with CBPQT4+. By contrast, the reason for M2 is because it forms a more stable cyclic monomer in dilute solution, which prevents its threading behavior with the blue-box. Compared with M2, the cyclic monomer of M3 is less stable and can undergo threading after ringopening. The colorless solutions of M1+CBPQT4+ and M2+CBPQT4+ also suggests that both M1 and M2 could not form relatively strong pseudorotaxane with blue-box in CHCl3. Then the threading behavior in dimethyl sulfoxide (DMSO) was studied, which can totally break quadruple hydrogen bonding. According to 1H NMR, no pseudorotaxane was found in M1+CBPQT4+ while very few pseudorotaxanes were formed in M2+CBPQT4+. By contrast, considerable amounts of pseudorotaxane were formed in M3+CBPQT4+. These phenomena further indicate that the longer the ethylene glycol chain, the greater the ability to thread the ring of blue-box.
In conclusion, we have described a ring-chain equilibrium supramolecular polymerization system based on quadruple hydrogen bonding, in which the spacer length of the monomers has a big influence on the ring-opening process. A combination of techniques including concentration-dependent 1H NMR, NOESY and viscosity measurement were employed to study this system. Moreover, the host-guest complexation between the monomers with the π-electron deficient macrocycle "blue-box" were also investigated. From this interesting model, new insight into the relationship between molecular structure and supramolecular polymerization is discovered, which is important to create tailor-made supramolecular polymeric materials.
4. Experimental section
4.1 Materials and instruments
The commercially available reagents and solvents were either employed as purchased or dried according to procedures described in the literature. Compounds 1a,  2,  M2,  and M3 were prepared according to literature procedure. All yields were given as isolated yields. NMR spectra were recorded on a Bruker AVANCE Ⅲ 300 MHz or a Bruker AVANCE Ⅲ 400 MHz spectrometer with internal standard tetramethylsilane (TMS) and solvent signals as internal references, where CDCl3 and CD3CN were dried using neutral aluminum oxide. NOESY experiments were performed on a Bruker AVANCE Ⅲ 400 MHz spectrometer. Low-resolution electrospray ionization mass spectra (LR-ESI-MS) were obtained on LCMS2020. High-resolution electrospray ionization mass spectra (HR-ESI-MS) were recorded on an Agilent Technologies 6540 UHD Accurate-Mass. Viscosity measurements were carried out with Ubbelohde micro viscometers (Shanghai Liangjing Glass Instrument Factory, 0.40 mm inner diameter) at 298 K in chloroform.
4.2 Synthesis of compound M1
Imidazolide 2 (0.68 g, 2.24 mmol) and 1a (0.20 g, 1.01 mmol) were dissolved in dry CHCl3 (30 mL) and this solution was stirred for 12 h under nitrogen at room temperature. To the reaction mixture CHCl3 (20 mL) was added and the organic layer was washed with 1 mol/L HCl (50 mL), saturated NaHCO3 (50 mL), brine (50 mL), and then dried over anhydrous MgSO4 and concentrated under reduced pressure. The resulting residue was subjected to column chromatography over silica gel (CHCl3/MeOH, V:V＝100:1) to afford compound M1 as a colorless viscous solid (0.50 g, 0.75 mmol, 74%). m.p. 263~265 ℃; 1H NMR (300 MHz, CDCl3) δ: 13.13 (s, 2H, NH), 12.04 (s, 2H, NH), 10.50 (s, 2H, NH), 6.85 (s, 4H, ArH), 5.82 (s, 2H, alkylidene-H), 4.06 (t, J＝5.7 Hz, 4H, OCH2), 3.73~3.58 (m, 4H, OCH2), 2.36~2.23 [m, 2H, CH(CH2)2], 1.73~1.50 (m, 8H, CH2), 1.35~1.21 (m, 8H, CH2), 0.92~0.85 (m, 12H, CH3); 13C NMR (75 MHz, CDCl3) δ: 173.1, 157.1, 155.4, 154.7, 153.1, 115.7, 106.4, 67.0, 45.4, 39.4, 32.9, 29.3, 26.6, 22.5, 13.9, 11.7; ESI-MS m/z: 667.25 ([M+H]+), 665.20 ([M－H]-); HR-ESI-MS calcd for C34H51N8O6 [M+H]+ 667.3926, found 667.3922.
Supporting Information Characterization spectra of compound M1 and 1H-1H NOESY of M2. The Supporting Information is available free of charge via the Internet at http://sioc-journal.cn.
Dedicated to the 40th anniversary of Chinese Journal of Organic Chemistry.
Wehner, M.; Würthner, F. Nat. Rev. Chem. 2020, 4, 38. doi: 10.1038/s41570-019-0153-8
Yang, L.; Tan, X.; Wang, Z.; Zhang, X. Chem. Rev. 2015, 115, 7196.. doi: 10.1021/cr500633b
Huang, F.; Scherman, O. A. Chem. Soc. Rev. 2012, 41, 5879. doi: 10.1039/c2cs90071h
Aida, T.; Meijer, E. W.; Stupp, S. I. Science 2012, 335, 813. doi: 10.1126/science.1205962
Brunsveld, L.; Folmer, B. J.; Meijer, E. W.; Sijbesma, R. P. Chem. Rev. 2001, 101, 4071. doi: 10.1021/cr990125q
Park, T.; Zimmerman, S. C. J. Am. Chem. Soc. 2006, 128, 11582. doi: 10.1021/ja0631854
Hirschberg, J. H. K. K.; Brunsveld, L.; Ramzi, A.; Vekemans, J. A. J. M.; Sijbesma, R. P.; Meijer, E. W. Nature 2000, 407, 167. doi: 10.1038/35025027
He, M.; Chen, X.; Liu, D.; Wei, D. Chin. Chem. Lett. 2019, 30, 961. doi: 10.1016/j.cclet.2019.01.008
Würthner, F.; Saha-Möller, C. R.; Fimmel, B.; Ogi, S.; Leowanawat, P.; Schmidt, D. Chem. Rev. 2016, 116, 962. doi: 10.1021/acs.chemrev.5b00188
Bentz, K. C.; Cohen, S. M. Angew. Chem., Int. Ed. 2018, 57, 14992. doi: 10.1002/anie.201806912
Li, Z.; Gu, J.; Qi, S.; Wu, D.; Gao, L.; Chen, Z.; Guo, J.; Li, X.; Wang, Y.; Yang, X.; Tu, Y. J. Am. Chem. Soc. 2017, 139, 14364. doi: 10.1021/jacs.7b07965
Wang, X.; Han, Y.; Liu, Y.; Zou, G.; Gao, Z.; Wang, F. Angew. Chem., Int. Ed. 2017, 56, 12466. doi: 10.1002/anie.201704294
徐悦莹, 王伟, 陈健壮, 林绍梁, 有机化学, 2018, 38, 2161.Xu, Y.; Wang, W.; Chen, J.; Lin, S. Chin. J. Org. Chem. 2018, 38, 2161(in Chinese).
Xiao, T.; Zhou, L.; Xu, L.; Zhong, W.; Zhao, W.; Sun, X.-Q.; Elmes, R. B. P. Chin. Chem. Lett. 2019, 30, 271. doi: 10.1016/j.cclet.2018.05.039
Xiao, T.; Zhong, W.; Zhou, L.; Xu, L.; Sun, X.-Q.; Elmes, R. B. P.; Hu, X.-Y.; Wang, L. Chin. Chem. Lett. 2019, 30, 31. doi: 10.1016/j.cclet.2018.05.034
Chen, Y.; Sun, S.; Lu, D.; Shi, Y.; Yao, Y. Chin. Chem. Lett. 2019, 30, 37 doi: 10.1016/j.cclet.2018.10.022
Dong, S.; Zheng, B.; Wang, F.; Huang, F. Acc. Chem. Res. 2014, 47, 1982. doi: 10.1021/ar5000456
Guo, D.-S.; Liu, Y. Chem. Soc. Rev. 2012, 41, 5907. doi: 10.1039/c2cs35075k
霍博超, 李斌, 苏杭, 曾宪强, 徐凯迪, 崔雷, 有机化学, 2019, 39, 1990.Huo, B.; Li, B.; Su, H.; Zeng, X.; Xu, K.; Cui, L. Chin. J. Org. Chem. 2019, 39, 1990(in Chinese).
Wang, Y.; Ping, G.; Li, C. Chem. Commun. 2016, 52, 9858. doi: 10.1039/C6CC03999E
Dai, D.; Li, Z.; Yang, J.; Wang, C.; Wu, J. R.; Wang, Y.; Zhang, D.; Yang, Y. W. J. Am. Chem. Soc. 2019, 141, 4756. doi: 10.1021/jacs.9b01546
Wang, Q.; Chen, Y.; Liu, Y. Polym. Chem. 2013, 4, 4192. doi: 10.1039/c3py00339f
Shi, Z. M.; Wu, C. F.; Zhou, T. Y.; Zhang, D. W.; Zhao, X.; Li, Z. T. Chem. Commun. 2013, 49, 2673. doi: 10.1039/c3cc38261c
Wei, P.; Yan, X.; Huang, F. Chem. Soc. Rev. 2015, 44, 815. doi: 10.1039/C4CS00327F
Sijbesma, R. P.; Beijer, F. H.; Brunsveld, L.; Folmer, B. J. B.; Hirschberg, J. H. K. K.; Lange, R. F. M.; Lowe, J. K. L.; Meijer, E. W. Science 1997, 278, 1601. doi: 10.1126/science.278.5343.1601
Zhang, T.; Ma, X.; Tian, H. Chem. Sci. 2020, 11, 482. doi: 10.1039/C9SC05502A
Yan, X.; Liu, Z.; Zhang, Q.; Lopez, J.; Wang, H.; Wu, H. C.; Niu, S.; Yan, H.; Wang, S.; Lei, T.; Li, J.; Qi, D.; Huang, P.; Huang, J.; Zhang, Y.; Wang, Y.; Li, G.; Tok, J. B.; Chen, X.; Bao, Z. J. Am. Chem. Soc. 2018, 140, 5280. doi: 10.1021/jacs.8b01682
Qin, B.; Zhang, S.; Song, Q.; Huang, Z.; Xu, J. F.; Zhang, X. Angew. Chem., Int. Ed. 2017, 56, 7639. doi: 10.1002/anie.201703572
Peng, H.-Q.; Zheng, X.; Han, T.; Kwok, R. T. K.; Lam, J. W. Y.; Huang, X.; Tang, B. Z. J. Am. Chem. Soc. 2017, 139, 10150. doi: 10.1021/jacs.7b05792
Goujon, A.; Mariani, G.; Lang, T.; Moulin, E.; Rawiso, M.; Buhler, E.; Giuseppone, N. J. Am. Chem. Soc. 2017, 139, 4923. doi: 10.1021/jacs.7b00983
Peng, H.-Q.; Sun, C.-L.; Niu, L.-Y.; Chen, Y.-Z.; Wu, L.-Z.; Tung, C.-H.; Yang, Q.-Z. Adv. Funct. Mater. 2016, 26, 5483. doi: 10.1002/adfm.201600593
Fu, X.; Gu, R.-R.; Zhang, Q.; Rao, S.-J.; Zheng, X.-L.; Qu, D.-H.; Tian, H. Polym. Chem. 2016, 7, 2166. doi: 10.1039/C6PY00309E
Wang, Q.; Zhang, P.; Li, Y.; Tian, L.; Cheng, M.; Lu, F.; Lu, X.; Fan, Q.; Huang, W. RSC Adv. 2017, 7, 29364. doi: 10.1039/C7RA05351G
肖唐鑫, 周玲, 魏小艳, 李正义, 孙小强, 有机化学, 2020, 40, 944.Xiao, T.; Zhou, L.; Wei, X.; Li, Z.; Sun, X. Chin. J. Org. Chem. 2020, 40, 944(in Chinese).
Xiao, T.; Xu, L.; Wang, J.; Li, Z.-Y.; Sun, X.-Q.; Wang, L. Org. Chem. Front. 2019, 6, 936. doi: 10.1039/C9QO00089E
Xiao, T.; Xu, L.; Götz, J.; Cheng, M.; Würthner, F.; Gu, J.; Feng, X.; Li, Z.-Y.; Sun, X.-Q.; Wang, L. Mater. Chem. Front. 2019, 3, 2738. doi: 10.1039/C9QM00595A
Guo, D.; Sijbesma, R. P.; Zuilhof, H. Org. Lett. 2004, 6, 3667. doi: 10.1021/ol048821m
Xiao, T.; Zhong, W.; Qi, L.; Gu, J.; Feng, X.; Yin, Y.; Li, Z.-Y.; Sun, X.-Q.; Cheng, M.; Wang, L. Polym. Chem. 2019, 10, 3342. doi: 10.1039/C9PY00312F
Xiao, T.; Li, S.-L.; Zhang, Y.; Lin, C.; Hu, B.; Guan, X.; Yu, Y.; Jiang, J.; Wang, L. Chem. Sci. 2012, 3, 1417. doi: 10.1039/c2sc01004f
de Greef, T. F. A.; Meijer, E. W. Nature 2008, 453, 171. doi: 10.1038/453171a
Hu, X.-Y.; Zhang, P.; Wu, X.; Xia, W.; Xiao, T.; Jiang, J.; Lin, C.; Wang, L. Polym. Chem. 2012, 3, 3060. doi: 10.1039/c2py20285a
Li, S.-L.; Xiao, T.; Xia, W.; Ding, X.; Yu, Y.; Jiang, J.; Wang, L. Chem.-Eur. J. 2011, 17, 10716. doi: 10.1002/chem.201100691
Zhang, K.-D.; Zhao, X.; Wang, G.-T.; Liu, Y.; Zhang, Y.; Lu, H.-J.; Jiang, X.-K.; Li, Z.-T. Angew. Chem., Int. Ed. 2011, 50, 9866. doi: 10.1002/anie.201104099
Liu, M.; Li, S.; Zhang, M.; Zhou, Q.; Wang, F.; Hu, M.; Fronczek, F. R.; Li, N.; Huang, F. Org. Biomol. Chem. 2009, 7, 1288. doi: 10.1039/b815929g
Anelli, P. L.; Ashton, P. R.; Ballardini, R.; Balzani, V.; Delgado, M.; Gandolfi, M. T.; Goodnow, T. T.; Kaifer, A. E.; Philp, D.; Pietraszkiewicz, M.; Prodi, L.; Reddington, M. V.; Slawin, A. M. Z.; Spencer, N.; Stoddart, J. F.; Vicent, C.; Williams, D. J. J. Am. Chem. Soc. 1992, 114, 193. doi: 10.1021/ja00027a027
Tsukamoto, T.; Sasahara, R.; Muranaka, A.; Miura, Y.; Suzuki, Y.; Kimura, M.; Miyagawa, S.; Kawasaki, T.; Ko-bayashi, N.; Uchiyama, M.; Tokunaga, Y. Org. Lett. 2018, 20, 4745. doi: 10.1021/acs.orglett.8b01727
Keizer, H. M.; Sijbesma, R. P.; Meijer, E. W. Eur. J. Org. Chem. 2004, 2004, 2553.
- PDF下载量: 1
- 文章访问数: 204
- HTML全文浏览量: 20