Citation: Wu Dunqi, Cheng Xuan, Liu Yankai, Cheng Guo, Guan Xiaoyu, Deng Qinghai. A New Class of Chiral Pincer-Type PNN Ligands for Pd-Catalyzed Asymmetric Allylic Alkylation[J]. Chinese Journal of Organic Chemistry, ;2020, 40(10): 3362-3370. doi: 10.6023/cjoc202005090 shu

A New Class of Chiral Pincer-Type PNN Ligands for Pd-Catalyzed Asymmetric Allylic Alkylation

The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234

Corresponding author: Deng Qinghai, qinghaideng@shnu.edu.cn
Received Date: 30 May 2020
Revised Date: 16 June 2020
Available Online: 8 July 2020
Fund Project: the Shanghai Engineering Research Center of Green Energy Chemical Engineering 18DZ2254200the National Natural Science Foundation of China 21772122Project supported by the National Natural Science Foundation of China (Nos. 21402119, 21772122) and the Shanghai Engineering Research Center of Green Energy Chemical Engineering (No. 18DZ2254200)the National Natural Science Foundation of China 21402119

Figures(2)

tridentate P, N, N-donor pincer ligands bearing two or three stereocenters, 1-(4, 5-dihydro-oxazol-2-yl)-N-(2-(diphenylphosphanyl)benzyl)methanamines (oxpma), were synthesized starting from readily available amino acids in five or six steps. They were applied in palladium-catalyzed asymmetric allylic alkylation of allylic acetates to afford the desired products with high enantioselectivities (up to 96% ee).
- PNN ligand,
- pincer ligand,
- asymmetric catalysis,
- asymmetric allylic alkylation
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