{"综述与进展":[{"abstractInfo":"多环型xanthone类天然产物是一类具有高度氧化态和六环骨架结构的天然产物.目前分离得到的此类化合物主要来源于放线菌.由于这类化合物具有结构特独、广泛的抗细菌活性、一定程度的抗真菌活性以及良好的抗肿瘤活性,吸引了大量有机合成和药物化学等领域学者的关注.近十年来,相关的生物和化学合成以及药物化学研究报道明显增多,主要总结了多环型xanthone类天然产物的合成研究进展.","abstractInfoCn":"多环型xanthone类天然产物是一类具有高度氧化态和六环骨架结构的天然产物.目前分离得到的此类化合物主要来源于放线菌.由于这类化合物具有结构特独、广泛的抗细菌活性、一定程度的抗真菌活性以及良好的抗肿瘤活性,吸引了大量有机合成和药物化学等领域学者的关注.近十年来,相关的生物和化学合成以及药物化学研究报道明显增多,主要总结了多环型xanthone类天然产物的合成研究进展.","abstractInfoEn":"Polycyclic xanthone natural products are a family of polyketides which are characterized by highly oxygenated angular hexacyclic frameworks. In the last decade, there has been a noticeable increase in reports on both synthetic and pharmacological investigations of this class of natural molecules due to their unique chemical structures and biological activities. Most members of this class of molecules show strong activities towards Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus<\/i>, potent antifungal activity and antitumour activity. The synthetic studies of some members of this class of natural products is summarized.","articleNo":"","authorCnList":["谢涛"," 何海兵"," 高栓虎"],"authorEnList":["Xie Tao"," He Haibing"," Gao Shuanhu"],"authorList":["谢涛"," 何海兵"," 高栓虎"],"authors":"谢涛, 何海兵, 高栓虎","authorsCn":"谢涛, 何海兵, 高栓虎","authorsEn":"Xie Tao, He Haibing, Gao Shuanhu","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"Review","citation":"谢涛, 何海兵, 高栓虎. 多环型Xanthone类天然产物的合成研究进展. 有机化学, 2020, 40(3): 551-562. doi: 10.6023/cjoc201911007.","citationCn":"谢涛, 何海兵, 高栓虎. 多环型Xanthone类天然产物的合成研究进展. 有机化学, 2020, 40(3): 551-562. doi: 10.6023/cjoc201911007.","citationEn":"谢涛, 何海兵, 高栓虎. Synthetic Progress of Polycyclic Xanthone. Chinese Journal of Organic Chemistry, 2020, 40(3): 551-562. doi: 10.6023/cjoc201911007.","doi":"10.6023/cjoc201911007","figContent":"yjhx-40-3-551-1.jpg$$yjhx-40-3-551-2.jpg$$yjhx-40-3-551-t1.jpg$$yjhx-40-3-551-T2.jpg$$yjhx-40-3-551-t3.jpg$$yjhx-40-3-551-t4.jpg$$yjhx-40-3-551-t5.jpg$$yjhx-40-3-551-t6.jpg$$yjhx-40-3-551-t7.jpg$$yjhx-40-3-551-t8.jpg$$yjhx-40-3-551-t9.jpg$$yjhx-40-3-551-t10.jpg$$yjhx-40-3-551-t11.jpg","figList":["yjhx-40-3-551-1.jpg","yjhx-40-3-551-2.jpg","yjhx-40-3-551-t1.jpg","yjhx-40-3-551-T2.jpg","yjhx-40-3-551-t3.jpg","yjhx-40-3-551-t4.jpg","yjhx-40-3-551-t5.jpg","yjhx-40-3-551-t6.jpg","yjhx-40-3-551-t7.jpg","yjhx-40-3-551-t8.jpg","yjhx-40-3-551-t9.jpg","yjhx-40-3-551-t10.jpg","yjhx-40-3-551-t11.jpg"],"firstFig":"yjhx-40-3-551-1.jpg","fpage":"551","highCitedState":"","htmlCount":153,"htmlFile":"","id":"94eacc72-29d5-4a68-8e02-f05d9ca210e1","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"多环型xanthone, 天然产物, 全合成","keywordCn":"多环型xanthone, 天然产物, 全合成","keywordCnList":["多环型xanthone"," 天然产物"," 全合成"],"keywordEn":"polycyclic xanthone, natural product, total synthesis","keywordEnList":["polycyclic xanthone"," natural product"," total synthesis"],"keywordList":["多环型xanthone"," 天然产物"," 全合成"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"562","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":34,"pdfSize":702.61,"pubDate":"","recommendState":"","releaseState":"1","secCount":0,"title":"多环型Xanthone类天然产物的合成研究进展","titleCn":"多环型Xanthone类天然产物的合成研究进展","titleEn":"Synthetic Progress of Polycyclic Xanthone","viewCount":542,"volume":"40","year":2020},{"abstractInfo":"经过几十年的发展,过渡金属催化的交叉偶联反应已经成为一类功能强大的有机合成方法,广泛应用于各种碳碳键和碳杂原子键的高效构建.最近几年化学家们发现在越来越多的情况下,不用外加光敏剂,可见光能直接促进过渡金属催化的交叉偶联反应,使原来无法发生或缓慢进行的偶联反应得以顺利实现.该类反应因条件简单、反应温和以及无需外加光敏剂等优点受到了广泛的关注.根据过渡金属的分类,综述了近些年来该类反应的研究进展.","abstractInfoCn":"经过几十年的发展,过渡金属催化的交叉偶联反应已经成为一类功能强大的有机合成方法,广泛应用于各种碳碳键和碳杂原子键的高效构建.最近几年化学家们发现在越来越多的情况下,不用外加光敏剂,可见光能直接促进过渡金属催化的交叉偶联反应,使原来无法发生或缓慢进行的偶联反应得以顺利实现.该类反应因条件简单、反应温和以及无需外加光敏剂等优点受到了广泛的关注.根据过渡金属的分类,综述了近些年来该类反应的研究进展.","abstractInfoEn":"Over the last decades, the transition metal-catalyzed cross-coupling reactions have become powerful organic synthetic methods for forming carbon-carbon and carbon-heteroatom bonds. Very recently, the introduction of visible light into transition metal catalysis opened a new avenue for achieving novel, highly enabling cross-coupling reactions that otherwise were elusive. This type of reaction has received extensive attention due to its simple, mild conditions and no need of photocatalyst. Based on the classification of transition metals, the research progress of transition metal-catalyzed cross-coupling reactions directly promoted by visible light is reviewed.","articleNo":"","authorCnList":["李祯龙"," 金健"," 黄莎华"],"authorEnList":["Li Zhenlong"," Jin Jian"," Huang Shahua"],"authorList":["李祯龙"," 金健"," 黄莎华"],"authors":"李祯龙, 金健, 黄莎华","authorsCn":"李祯龙, 金健, 黄莎华","authorsEn":"Li Zhenlong, Jin Jian, Huang Shahua","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"Review","citation":"李祯龙, 金健, 黄莎华. 可见光直接促进的过渡金属催化交叉偶联反应研究进展. 有机化学, 2020, 40(3): 563-574. doi: 10.6023/cjoc201910031.","citationCn":"李祯龙, 金健, 黄莎华. 可见光直接促进的过渡金属催化交叉偶联反应研究进展. 有机化学, 2020, 40(3): 563-574. doi: 10.6023/cjoc201910031.","citationEn":"李祯龙, 金健, 黄莎华. Recent Advances in Transition Metal-Catalyzed Cross-Coupling Reactions Directly Promoted by Visible Light. Chinese Journal of Organic Chemistry, 2020, 40(3): 563-574. doi: 10.6023/cjoc201910031.","doi":"10.6023/cjoc201910031","figContent":"yjhx-40-3-563-t1.jpg$$yjhx-40-3-563-t2.jpg$$yjhx-40-3-563-t3.jpg$$yjhx-40-3-563-t4.jpg$$yjhx-40-3-563-t5.jpg$$yjhx-40-3-563-t6.jpg$$yjhx-40-3-563-t7.jpg$$yjhx-40-3-563-t8.jpg$$yjhx-40-3-563-t9.jpg$$yjhx-40-3-563-t10.jpg","figList":["yjhx-40-3-563-t1.jpg","yjhx-40-3-563-t2.jpg","yjhx-40-3-563-t3.jpg","yjhx-40-3-563-t4.jpg","yjhx-40-3-563-t5.jpg","yjhx-40-3-563-t6.jpg","yjhx-40-3-563-t7.jpg","yjhx-40-3-563-t8.jpg","yjhx-40-3-563-t9.jpg","yjhx-40-3-563-t10.jpg"],"firstFig":"yjhx-40-3-563-t1.jpg","fpage":"563","highCitedState":"","htmlCount":145,"htmlFile":"","id":"4b8eb249-6351-4411-b843-662e1074bac4","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"可见光促进, 过渡金属催化, 交叉偶联","keywordCn":"可见光促进, 过渡金属催化, 交叉偶联","keywordCnList":["可见光促进"," 过渡金属催化"," 交叉偶联"],"keywordEn":"visible light-promoted, transition metal-catalyzed, cross-coupling","keywordEnList":["visible light-promoted"," transition metal-catalyzed"," cross-coupling"],"keywordList":["可见光促进"," 过渡金属催化"," 交叉偶联"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"574","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":37,"pdfSize":891.19,"pubDate":"2020-03-01","recommendState":"","releaseState":"1","secCount":0,"title":"可见光直接促进的过渡金属催化交叉偶联反应研究进展","titleCn":"可见光直接促进的过渡金属催化交叉偶联反应研究进展","titleEn":"Recent Advances in Transition Metal-Catalyzed Cross-Coupling Reactions Directly Promoted by Visible Light","viewCount":537,"volume":"40","year":2020},{"abstractInfo":"光学纯胺在合成与药物化学领域都有着广泛的应用,发展其高效的合成方法一直以来是有机化学界的研究热点.其中通过N酰基化及去酰基化动力学拆分方法获得光学纯胺化合物,已经成为合成手性胺类化合物的重要方法.近年来,基于非酰基化(或去酰基化)的不对称反应实现外消旋胺的动力学拆分的报道不断涌现,包括一些氨基不参与反应的非酰基化(或去酰基化)不对称反应的外消旋胺的动力学拆分.根据氮原子是否参与反应以及反应类型的不同,总结了外消旋胺的化学催化动力学拆分的研究进展.","abstractInfoCn":"光学纯胺在合成与药物化学领域都有着广泛的应用,发展其高效的合成方法一直以来是有机化学界的研究热点.其中通过N酰基化及去酰基化动力学拆分方法获得光学纯胺化合物,已经成为合成手性胺类化合物的重要方法.近年来,基于非酰基化(或去酰基化)的不对称反应实现外消旋胺的动力学拆分的报道不断涌现,包括一些氨基不参与反应的非酰基化(或去酰基化)不对称反应的外消旋胺的动力学拆分.根据氮原子是否参与反应以及反应类型的不同,总结了外消旋胺的化学催化动力学拆分的研究进展.","abstractInfoEn":"Enantiopure amines are important building blocks with a plethora of applications in the fields of medicine, agriculture and materials. Kinetic resolution (KR) of racemic amines is one of the most important methods for obtaining enantiopure amines. However, KR of amines is little investigated because of their high reactivity and coordinating ability in the corresponding KR of alcohols. Till now, major developments using non-enzymatic catalysts for KR of amines have been extensively achieved by catalytic acylation (or deacylation). Only recently the non-acylation KR of amines is improving. The relatively wide range of different catalytic asymmetric reactions have been employed as strategies for the efficient KR of amines. For some cases, the asymmetric reactions do not involve with nitrogen atoms of racemic substrates. This review aims to introduce the development of the non-acylation KR of amines for the synthesis of enantiopure amines.","articleNo":"","authorCnList":["唐亮"," 李雪薇"," 谢芳"," 张万斌"],"authorEnList":["Tang Liang"," Li Xuewei"," Xie Fang"," Zhang Wanbin"],"authorList":["唐亮"," 李雪薇"," 谢芳"," 张万斌"],"authors":"唐亮, 李雪薇, 谢芳, 张万斌","authorsCn":"唐亮, 李雪薇, 谢芳, 张万斌","authorsEn":"Tang Liang, Li Xuewei, Xie Fang, Zhang Wanbin","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"Review","citation":"唐亮, 李雪薇, 谢芳, 张万斌. 胺及其衍生物的非酰基化动力学拆分. 有机化学, 2020, 40(3): 575-588. doi: 10.6023/cjoc201910010.","citationCn":"唐亮, 李雪薇, 谢芳, 张万斌. 胺及其衍生物的非酰基化动力学拆分. 有机化学, 2020, 40(3): 575-588. doi: 10.6023/cjoc201910010.","citationEn":"唐亮, 李雪薇, 谢芳, 张万斌. Catalytic Kinetic Resolution of Amines and Their Derivatives by Non-acylation Reaction. Chinese Journal of Organic Chemistry, 2020, 40(3): 575-588. doi: 10.6023/cjoc201910010.","doi":"10.6023/cjoc201910010","figContent":"yjhx-40-3-575-S1.jpg$$yjhx-40-3-575-S2.jpg$$yjhx-40-3-575-S3.jpg$$yjhx-40-3-575-S4.jpg$$yjhx-40-3-575-S5.jpg$$yjhx-40-3-575-S6.jpg$$yjhx-40-3-575-S7.jpg$$yjhx-40-3-575-S8.jpg$$yjhx-40-3-575-S9.jpg$$yjhx-40-3-575-S10.jpg$$yjhx-40-3-575-S11.jpg$$yjhx-40-3-575-S12.jpg$$yjhx-40-3-575-S13.jpg$$yjhx-40-3-575-S14.jpg$$yjhx-40-3-575-S15.jpg$$yjhx-40-3-575-S16.jpg$$yjhx-40-3-575-S17.jpg$$yjhx-40-3-575-S18.jpg$$yjhx-40-3-575-S19.jpg$$yjhx-40-3-575-S20.jpg$$yjhx-40-3-575-S21.jpg$$yjhx-40-3-575-S22.jpg$$yjhx-40-3-575-S23.jpg$$yjhx-40-3-575-S24.jpg$$yjhx-40-3-575-S25.jpg$$yjhx-40-3-575-S26.jpg$$yjhx-40-3-575-S27.jpg$$yjhx-40-3-575-S28.jpg$$yjhx-40-3-575-S29.jpg$$yjhx-40-3-575-S30.jpg$$yjhx-40-3-575-S31.jpg$$yjhx-40-3-575-S32.jpg$$yjhx-40-3-575-S33.jpg$$yjhx-40-3-575-S34.jpg$$yjhx-40-3-575-S35.jpg","figList":["yjhx-40-3-575-S1.jpg","yjhx-40-3-575-S2.jpg","yjhx-40-3-575-S3.jpg","yjhx-40-3-575-S4.jpg","yjhx-40-3-575-S5.jpg","yjhx-40-3-575-S6.jpg","yjhx-40-3-575-S7.jpg","yjhx-40-3-575-S8.jpg","yjhx-40-3-575-S9.jpg","yjhx-40-3-575-S10.jpg","yjhx-40-3-575-S11.jpg","yjhx-40-3-575-S12.jpg","yjhx-40-3-575-S13.jpg","yjhx-40-3-575-S14.jpg","yjhx-40-3-575-S15.jpg","yjhx-40-3-575-S16.jpg","yjhx-40-3-575-S17.jpg","yjhx-40-3-575-S18.jpg","yjhx-40-3-575-S19.jpg","yjhx-40-3-575-S20.jpg","yjhx-40-3-575-S21.jpg","yjhx-40-3-575-S22.jpg","yjhx-40-3-575-S23.jpg","yjhx-40-3-575-S24.jpg","yjhx-40-3-575-S25.jpg","yjhx-40-3-575-S26.jpg","yjhx-40-3-575-S27.jpg","yjhx-40-3-575-S28.jpg","yjhx-40-3-575-S29.jpg","yjhx-40-3-575-S30.jpg","yjhx-40-3-575-S31.jpg","yjhx-40-3-575-S32.jpg","yjhx-40-3-575-S33.jpg","yjhx-40-3-575-S34.jpg","yjhx-40-3-575-S35.jpg"],"firstFig":"yjhx-40-3-575-S1.jpg","fpage":"575","highCitedState":"","htmlCount":81,"htmlFile":"","id":"c5c00954-3929-4a89-a551-b47a3c74d7de","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"光学纯胺, 动力学拆分, 非酶催化, 非酰基化(去酰基化), 不对称催化反应","keywordCn":"光学纯胺, 动力学拆分, 非酶催化, 非酰基化(去酰基化), 不对称催化反应","keywordCnList":["光学纯胺"," 动力学拆分"," 非酶催化"," 非酰基化(去酰基化)"," 不对称催化反应"],"keywordEn":"enantiopure amines, kinetic resolution, nonenzymatic, non-acylation, catalytic asymmetric reactions","keywordEnList":["enantiopure amines"," kinetic resolution"," nonenzymatic"," non-acylation"," catalytic asymmetric reactions"],"keywordList":["光学纯胺"," 动力学拆分"," 非酶催化"," 非酰基化(去酰基化)"," 不对称催化反应"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"588","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":22,"pdfSize":797.82,"pubDate":"2020-03-25","recommendState":"","releaseState":"1","secCount":0,"title":"胺及其衍生物的非酰基化动力学拆分","titleCn":"胺及其衍生物的非酰基化动力学拆分","titleEn":"Catalytic Kinetic Resolution of Amines and Their Derivatives by Non-acylation Reaction","viewCount":328,"volume":"40","year":2020},{"abstractInfo":"C—N键广泛存在于药物分子、天然产物及功能材料中,开发简洁高效的C—N键构建方法具有重要意义.近年来,无过渡金属体系下C(sp2<\/sup>)—H键的自由基反应构建C—N键取得了诸多进展.该方法反应条件相对温和,反应活性较高,为C—N键构建提供了一条新途径.根据氮源类型的不同,对近年来C(sp2<\/sup>)—H键的自由基反应构建C—N键的研究进展进行简要论述.","abstractInfoCn":"C—N键广泛存在于药物分子、天然产物及功能材料中,开发简洁高效的C—N键构建方法具有重要意义.近年来,无过渡金属体系下C(sp2<\/sup>)—H键的自由基反应构建C—N键取得了诸多进展.该方法反应条件相对温和,反应活性较高,为C—N键构建提供了一条新途径.根据氮源类型的不同,对近年来C(sp2<\/sup>)—H键的自由基反应构建C—N键的研究进展进行简要论述.","abstractInfoEn":"The C-N bond is widely found in medicinal molecules, natural products and functional materials. Therefore, it has great significance to develop simple and efficient methods for the construction of C-N bond. Recently, remarkable progress has been made in construction of C-N bond involving C(sp2<\/sup>)-H bond through transition-metal-free radical reactions. Due to the relatively mild reaction condition and high reactivity, it provides a novel approach to construct C-N bond. In this review, the recent developments in this area are summarized on the basis of different nitrogen sources.","articleNo":"","authorCnList":["吴燕"," 陈锦杨"," 李强"," 魏文廷"],"authorEnList":["Wu Yan"," Chen Jinyang"," Li Qiang"," Wei Wenting"],"authorList":["吴燕"," 陈锦杨"," 李强"," 魏文廷"],"authors":"吴燕, 陈锦杨, 李强, 魏文廷","authorsCn":"吴燕, 陈锦杨, 李强, 魏文廷","authorsEn":"Wu Yan, Chen Jinyang, Li Qiang, Wei Wenting","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"Review","citation":"吴燕, 陈锦杨, 李强, 魏文廷. 无过渡金属体系下C (sp2<\/sup>)—H键的自由基反应构建C—N键研究进展. 有机化学, 2020, 40(3): 589-597. doi: 10.6023/cjoc201909032.","citationCn":"吴燕, 陈锦杨, 李强, 魏文廷. 无过渡金属体系下C (sp2<\/sup>)—H键的自由基反应构建C—N键研究进展. 有机化学, 2020, 40(3): 589-597. doi: 10.6023/cjoc201909032.","citationEn":"吴燕, 陈锦杨, 李强, 魏文廷. Progress in C—N Bond Formation Involving C(sp2<\/sup>)—H Bond through Transition-Metal-Free Radical Reactions. Chinese Journal of Organic Chemistry, 2020, 40(3): 589-597. doi: 10.6023/cjoc201909032.","doi":"10.6023/cjoc201909032","figContent":"yjhx-40-3-589-S1.jpg$$yjhx-40-3-589-S2.jpg$$yjhx-40-3-589-S3.jpg$$yjhx-40-3-589-S4.jpg","figList":["yjhx-40-3-589-S1.jpg","yjhx-40-3-589-S2.jpg","yjhx-40-3-589-S3.jpg","yjhx-40-3-589-S4.jpg"],"firstFig":"yjhx-40-3-589-S1.jpg","fpage":"589","highCitedState":"","htmlCount":47,"htmlFile":"","id":"d9850b92-84ef-4912-9f5e-fc0d5c88c66b","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"C—N键, C (sp2<\/sup>)—H键, 无过渡金属, 自由基","keywordCn":"C—N键, C (sp2<\/sup>)—H键, 无过渡金属, 自由基","keywordCnList":["C—N键"," C (sp2<\/sup>)—H键"," 无过渡金属"," 自由基"],"keywordEn":"C—N bond, C (sp2<\/sup>)—H bond, transition-metal-free, radical","keywordEnList":["C—N bond"," C (sp2<\/sup>)—H bond"," transition-metal-free"," radical"],"keywordList":["C—N键"," C (sp2<\/sup>)—H键"," 无过渡金属"," 自由基"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"597","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":19,"pdfSize":674.98,"pubDate":"2020-03-25","recommendState":"","releaseState":"1","secCount":0,"title":"无过渡金属体系下C (sp2<\/sup>)—H键的自由基反应构建C—N键研究进展","titleCn":"无过渡金属体系下C (sp2<\/sup>)—H键的自由基反应构建C—N键研究进展","titleEn":"Progress in C—N Bond Formation Involving C(sp2<\/sup>)—H Bond through Transition-Metal-Free Radical Reactions","viewCount":298,"volume":"40","year":2020},{"abstractInfo":"烷基羧酸广泛存在于自然界之中,科研工作者一直致力于开发以来源丰富的烷基羧酸及其衍生物作为起始原料的反应.烷基羧酸及其衍生物在可见光氧化还原作用下可以高效地生成烷基自由基,从而在温和条件下用于构筑各类化学键.以可见光催化烷基羧酸及其衍生物的脱羧自由基反应类型为线索,系统地综述了近年来在可见光条件下烷基羧酸及其衍生物的脱羧官能团化反应研究进展.","abstractInfoCn":"烷基羧酸广泛存在于自然界之中,科研工作者一直致力于开发以来源丰富的烷基羧酸及其衍生物作为起始原料的反应.烷基羧酸及其衍生物在可见光氧化还原作用下可以高效地生成烷基自由基,从而在温和条件下用于构筑各类化学键.以可见光催化烷基羧酸及其衍生物的脱羧自由基反应类型为线索,系统地综述了近年来在可见光条件下烷基羧酸及其衍生物的脱羧官能团化反应研究进展.","abstractInfoEn":"Alkyl carboxylic acids are among the most ubiquitous organic molecules found in nature. The reactions using abundant carboxylic acid and its derivatives as starting materials deserve widespread attention over the world. They are often easy to generate alkyl radical by photoredox catalysis under mild conditions for building various chemical bonds in organic chemistry. Based on the reaction modes, decarboxylation of alkylcarboxylic acids and their derivatives, the recent progress in decarboxylation of alkylcarboxylic acids and their derivatives under visible light is reviewed.","articleNo":"","authorCnList":["周明东"," 覃丕涛"," 经理珂"," 孙京"," 杜海武"],"authorEnList":["Zhou Mingdong"," Qin Pitao"," Jing Like"," Sun Jing"," Du Haiwu"],"authorList":["周明东"," 覃丕涛"," 经理珂"," 孙京"," 杜海武"],"authors":"周明东, 覃丕涛, 经理珂, 孙京, 杜海武","authorsCn":"周明东, 覃丕涛, 经理珂, 孙京, 杜海武","authorsEn":"Zhou Mingdong, Qin Pitao, Jing Like, Sun Jing, Du Haiwu","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"Review","citation":"周明东, 覃丕涛, 经理珂, 孙京, 杜海武. 可见光诱导烷基羧酸及其衍生物的脱羧偶联反应研究进展. 有机化学, 2020, 40(3): 598-613. doi: 10.6023/cjoc201909030.","citationCn":"周明东, 覃丕涛, 经理珂, 孙京, 杜海武. 可见光诱导烷基羧酸及其衍生物的脱羧偶联反应研究进展. 有机化学, 2020, 40(3): 598-613. doi: 10.6023/cjoc201909030.","citationEn":"周明东, 覃丕涛, 经理珂, 孙京, 杜海武. Progress in Photoinduced Decarboxylative Radical Cross-Coupling of Alkyl Carboxylic Acids and Their Derivatives. Chinese Journal of Organic Chemistry, 2020, 40(3): 598-613. doi: 10.6023/cjoc201909030.","doi":"10.6023/cjoc201909030","figContent":"yjhx-40-3-598-S1.jpg$$yjhx-40-3-598-S2.jpg$$yjhx-40-3-598-S3.jpg$$yjhx-40-3-598-S4.jpg$$yjhx-40-3-598-S5.jpg$$yjhx-40-3-598-S6.jpg$$yjhx-40-3-598-S7.jpg$$yjhx-40-3-598-S8.jpg$$yjhx-40-3-598-S9.jpg$$yjhx-40-3-598-S10.jpg$$yjhx-40-3-598-S11.jpg$$yjhx-40-3-598-S12.jpg$$yjhx-40-3-598-S13.jpg$$yjhx-40-3-598-S14.jpg$$yjhx-40-3-598-S15.jpg$$yjhx-40-3-598-S16.jpg$$yjhx-40-3-598-S17.jpg$$yjhx-40-3-598-S18.jpg$$yjhx-40-3-598-S19.jpg$$yjhx-40-3-598-S20.jpg$$yjhx-40-3-598-S21.jpg","figList":["yjhx-40-3-598-S1.jpg","yjhx-40-3-598-S2.jpg","yjhx-40-3-598-S3.jpg","yjhx-40-3-598-S4.jpg","yjhx-40-3-598-S5.jpg","yjhx-40-3-598-S6.jpg","yjhx-40-3-598-S7.jpg","yjhx-40-3-598-S8.jpg","yjhx-40-3-598-S9.jpg","yjhx-40-3-598-S10.jpg","yjhx-40-3-598-S11.jpg","yjhx-40-3-598-S12.jpg","yjhx-40-3-598-S13.jpg","yjhx-40-3-598-S14.jpg","yjhx-40-3-598-S15.jpg","yjhx-40-3-598-S16.jpg","yjhx-40-3-598-S17.jpg","yjhx-40-3-598-S18.jpg","yjhx-40-3-598-S19.jpg","yjhx-40-3-598-S20.jpg","yjhx-40-3-598-S21.jpg"],"firstFig":"yjhx-40-3-598-S1.jpg","fpage":"598","highCitedState":"","htmlCount":104,"htmlFile":"","id":"24efbe30-2bea-4eaf-9402-3c2ddf210140","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"可见光催化, 脱羧反应, 烷基自由基","keywordCn":"可见光催化, 脱羧反应, 烷基自由基","keywordCnList":["可见光催化"," 脱羧反应"," 烷基自由基"],"keywordEn":"photocatalysis, decarboxylative, alkyl radical","keywordEnList":["photocatalysis"," decarboxylative"," alkyl radical"],"keywordList":["可见光催化"," 脱羧反应"," 烷基自由基"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"613","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":25,"pdfSize":953.24,"pubDate":"2020-03-25","recommendState":"","releaseState":"1","secCount":0,"title":"可见光诱导烷基羧酸及其衍生物的脱羧偶联反应研究进展","titleCn":"可见光诱导烷基羧酸及其衍生物的脱羧偶联反应研究进展","titleEn":"Progress in Photoinduced Decarboxylative Radical Cross-Coupling of Alkyl Carboxylic Acids and Their Derivatives","viewCount":497,"volume":"40","year":2020},{"abstractInfo":"含有氢键供体基团构筑的大环化合物因其结构中具有可以提供氢键供体的N—H基团,可以为大环化合物的主客体化学提供额外的分子间作用力,在分子识别、自组装以及超分子催化等领域被广泛应用.综述了近十年基于(硫)脲键、酰胺键构筑的大环化合物的合成方法及其在分子识别中的最新研究进展.为今后此类大环化合物的合成及应用提供参考.","abstractInfoCn":"含有氢键供体基团构筑的大环化合物因其结构中具有可以提供氢键供体的N—H基团,可以为大环化合物的主客体化学提供额外的分子间作用力,在分子识别、自组装以及超分子催化等领域被广泛应用.综述了近十年基于(硫)脲键、酰胺键构筑的大环化合物的合成方法及其在分子识别中的最新研究进展.为今后此类大环化合物的合成及应用提供参考.","abstractInfoEn":"Because of the N-H group structure in the macrocyclic compound containing hydrogen bond Donors, it can provide additional intermolecular forces in the host-guest chemistry, and this character is widely used in the molecular recognition, self-assembly, supramolecular catalysis and other fields. The recent progress on the synthetic methods of macrocyclic compounds based on (thio) urea, amide and its molecular recognition in 2010~2019 are summarized. It is hoped that this review can be referred to synthesis and applications of this kind of macrocyclic compounds.","articleNo":"","authorCnList":["黄国保"," 陈志林"," 韦贤生"," 陈钰"," 李秀英"," 仲辉"," 谭明雄"],"authorEnList":["Huang Guobao"," Chen Zhilin"," Wei Xiansheng"," Chen Yu"," Li Xiuying"," Zhong Hui"," Tan Mingxiong"],"authorList":["黄国保"," 陈志林"," 韦贤生"," 陈钰"," 李秀英"," 仲辉"," 谭明雄"],"authors":"黄国保, 陈志林, 韦贤生, 陈钰, 李秀英, 仲辉, 谭明雄","authorsCn":"黄国保, 陈志林, 韦贤生, 陈钰, 李秀英, 仲辉, 谭明雄","authorsEn":"Huang Guobao, Chen Zhilin, Wei Xiansheng, Chen Yu, Li Xiuying, Zhong Hui, Tan Mingxiong","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"Reviews","citation":"黄国保, 陈志林, 韦贤生, 陈钰, 李秀英, 仲辉, 谭明雄. 含有氢键供体大环化合物的构筑及其功能研究进展. 有机化学, 2020, 40(3): 614-624. doi: 10.6023/cjoc201909029.","citationCn":"黄国保, 陈志林, 韦贤生, 陈钰, 李秀英, 仲辉, 谭明雄. 含有氢键供体大环化合物的构筑及其功能研究进展. 有机化学, 2020, 40(3): 614-624. doi: 10.6023/cjoc201909029.","citationEn":"黄国保, 陈志林, 韦贤生, 陈钰, 李秀英, 仲辉, 谭明雄. Recent Progress on the Construction and Function of Macrocyclic Compounds Containing Hydrogen Bond Donors. Chinese Journal of Organic Chemistry, 2020, 40(3): 614-624. doi: 10.6023/cjoc201909029.","doi":"10.6023/cjoc201909029","figContent":"yjhx-40-3-614-S1.jpg$$yjhx-40-3-614-S2.jpg$$yjhx-40-3-614-S3.jpg$$yjhx-40-3-614-S4.jpg$$yjhx-40-3-614-S5.jpg$$yjhx-40-3-614-S6.jpg$$yjhx-40-3-614-1.jpg$$yjhx-40-3-614-2.jpg$$yjhx-40-3-614-3.jpg$$yjhx-40-3-614-4.jpg$$yjhx-40-3-614-5.jpg$$yjhx-40-3-614-S7.jpg$$yjhx-40-3-614-6.jpg$$yjhx-40-3-614-S8.jpg","figList":["yjhx-40-3-614-S1.jpg","yjhx-40-3-614-S2.jpg","yjhx-40-3-614-S3.jpg","yjhx-40-3-614-S4.jpg","yjhx-40-3-614-S5.jpg","yjhx-40-3-614-S6.jpg","yjhx-40-3-614-1.jpg","yjhx-40-3-614-2.jpg","yjhx-40-3-614-3.jpg","yjhx-40-3-614-4.jpg","yjhx-40-3-614-5.jpg","yjhx-40-3-614-S7.jpg","yjhx-40-3-614-6.jpg","yjhx-40-3-614-S8.jpg"],"firstFig":"yjhx-40-3-614-S1.jpg","fpage":"614","highCitedState":"","htmlCount":76,"htmlFile":"","id":"49264dff-4c8b-4287-8ee6-3a354717a4c0","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"氢键供体基团, 大环化合物, 合成, 分子识别","keywordCn":"氢键供体基团, 大环化合物, 合成, 分子识别","keywordCnList":["氢键供体基团"," 大环化合物"," 合成"," 分子识别"],"keywordEn":"hydrogen bond donor group, macrocyclic compounds, synthesis, molecular recognition","keywordEnList":["hydrogen bond donor group"," macrocyclic compounds"," synthesis"," molecular recognition"],"keywordList":["氢键供体基团"," 大环化合物"," 合成"," 分子识别"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"624","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":6,"pdfSize":1309.88,"pubDate":"2020-03-25","recommendState":"","releaseState":"1","secCount":0,"title":"含有氢键供体大环化合物的构筑及其功能研究进展","titleCn":"含有氢键供体大环化合物的构筑及其功能研究进展","titleEn":"Recent Progress on the Construction and Function of Macrocyclic Compounds Containing Hydrogen Bond Donors","viewCount":339,"volume":"40","year":2020},{"abstractInfo":"过渡金属催化C—H活化反应中,配体能够对催化中心的空间及电子效应进行调控,从而实现芳烃C—H键的选择性官能化.近年来,配体促进芳烃远程C—H键官能化反应研究有了新的进展.对近几年来配体促进的过渡金属催化芳烃远程meta<\/i>-C—H键选择性官能化反应进行了系统总结,并对该研究领域的局限性和未来的发展前景进行总结和展望.","abstractInfoCn":"过渡金属催化C—H活化反应中,配体能够对催化中心的空间及电子效应进行调控,从而实现芳烃C—H键的选择性官能化.近年来,配体促进芳烃远程C—H键官能化反应研究有了新的进展.对近几年来配体促进的过渡金属催化芳烃远程meta<\/i>-C—H键选择性官能化反应进行了系统总结,并对该研究领域的局限性和未来的发展前景进行总结和展望.","abstractInfoEn":"Ligands can regulate both the steric and electronic effects of the catalytic center in transition-metal-catalyzed C-H activation reactions, leading to the site-selective C-H functionalization of arenes. In recent years, ligand-promoted remote C-H functionalization of arenes has developed rapidly. The recent progress on ligand-promoted transition-metal-catalyzed remote meta<\/i>-selective C-H bond functionalization of arenes is summarized, and the limitations of the research field and prospects for future development are presented.","articleNo":"","authorCnList":["田万发"," 李娜"," 彭子赫"," 冯丽华"," 麦曦"," 贺永勤"],"authorEnList":["Tian Wanfa"," Li Na"," Peng Zihe"," Feng Lihua"," Mai Xi"," He Yongqin"],"authorList":["田万发"," 李娜"," 彭子赫"," 冯丽华"," 麦曦"," 贺永勤"],"authors":"田万发, 李娜, 彭子赫, 冯丽华, 麦曦, 贺永勤","authorsCn":"田万发, 李娜, 彭子赫, 冯丽华, 麦曦, 贺永勤","authorsEn":"Tian Wanfa, Li Na, Peng Zihe, Feng Lihua, Mai Xi, He Yongqin","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"Reviews","citation":"田万发, 李娜, 彭子赫, 冯丽华, 麦曦, 贺永勤. 配体促进的过渡金属催化芳烃远程meta<\/i>-C—H键官能化反应研究进展. 有机化学, 2020, 40(3): 625-644. doi: 10.6023/cjoc201909015.","citationCn":"田万发, 李娜, 彭子赫, 冯丽华, 麦曦, 贺永勤. 配体促进的过渡金属催化芳烃远程meta<\/i>-C—H键官能化反应研究进展. 有机化学, 2020, 40(3): 625-644. doi: 10.6023/cjoc201909015.","citationEn":"田万发, 李娜, 彭子赫, 冯丽华, 麦曦, 贺永勤. Recent Advances in Ligand-Promoted Transition-Metal-Catalyzed Remote meta<\/i>-C—H Functionalization of Arenes. Chinese Journal of Organic Chemistry, 2020, 40(3): 625-644. doi: 10.6023/cjoc201909015.","doi":"10.6023/cjoc201909015","figContent":"yjhx-40-3-625-S1.jpg$$yjhx-40-3-625-S2.jpg$$yjhx-40-3-625-S3.jpg$$yjhx-40-3-625-S4.jpg$$yjhx-40-3-625-S5.jpg$$yjhx-40-3-625-S6.jpg$$yjhx-40-3-625-S7.jpg$$yjhx-40-3-625-S8.jpg$$yjhx-40-3-625-S9.jpg$$yjhx-40-3-625-S10.jpg$$yjhx-40-3-625-S11.jpg$$yjhx-40-3-625-S12.jpg$$yjhx-40-3-625-S13.jpg$$yjhx-40-3-625-S14.jpg$$yjhx-40-3-625-S15.jpg$$yjhx-40-3-625-S16.jpg$$yjhx-40-3-625-S17.jpg$$yjhx-40-3-625-S18.jpg$$yjhx-40-3-625-S19.jpg$$yjhx-40-3-625-S20.jpg$$yjhx-40-3-625-S21.jpg$$yjhx-40-3-625-S22.jpg$$yjhx-40-3-625-S23.jpg$$yjhx-40-3-625-S24.jpg$$yjhx-40-3-625-S25.jpg$$yjhx-40-3-625-S26.jpg$$yjhx-40-3-625-S27.jpg$$yjhx-40-3-625-S28.jpg$$yjhx-40-3-625-S29.jpg$$yjhx-40-3-625-S30.jpg$$yjhx-40-3-625-S31.jpg$$yjhx-40-3-625-S32.jpg$$yjhx-40-3-625-S33.jpg$$yjhx-40-3-625-S34.jpg$$yjhx-40-3-625-S35.jpg$$yjhx-40-3-625-S36.jpg$$yjhx-40-3-625-S37.jpg$$yjhx-40-3-625-S38.jpg$$yjhx-40-3-625-S39.jpg$$yjhx-40-3-625-S40.jpg$$yjhx-40-3-625-S41.jpg$$yjhx-40-3-625-S42.jpg$$yjhx-40-3-625-S43.jpg$$yjhx-40-3-625-S44.jpg$$yjhx-40-3-625-S45.jpg","figList":["yjhx-40-3-625-S1.jpg","yjhx-40-3-625-S2.jpg","yjhx-40-3-625-S3.jpg","yjhx-40-3-625-S4.jpg","yjhx-40-3-625-S5.jpg","yjhx-40-3-625-S6.jpg","yjhx-40-3-625-S7.jpg","yjhx-40-3-625-S8.jpg","yjhx-40-3-625-S9.jpg","yjhx-40-3-625-S10.jpg","yjhx-40-3-625-S11.jpg","yjhx-40-3-625-S12.jpg","yjhx-40-3-625-S13.jpg","yjhx-40-3-625-S14.jpg","yjhx-40-3-625-S15.jpg","yjhx-40-3-625-S16.jpg","yjhx-40-3-625-S17.jpg","yjhx-40-3-625-S18.jpg","yjhx-40-3-625-S19.jpg","yjhx-40-3-625-S20.jpg","yjhx-40-3-625-S21.jpg","yjhx-40-3-625-S22.jpg","yjhx-40-3-625-S23.jpg","yjhx-40-3-625-S24.jpg","yjhx-40-3-625-S25.jpg","yjhx-40-3-625-S26.jpg","yjhx-40-3-625-S27.jpg","yjhx-40-3-625-S28.jpg","yjhx-40-3-625-S29.jpg","yjhx-40-3-625-S30.jpg","yjhx-40-3-625-S31.jpg","yjhx-40-3-625-S32.jpg","yjhx-40-3-625-S33.jpg","yjhx-40-3-625-S34.jpg","yjhx-40-3-625-S35.jpg","yjhx-40-3-625-S36.jpg","yjhx-40-3-625-S37.jpg","yjhx-40-3-625-S38.jpg","yjhx-40-3-625-S39.jpg","yjhx-40-3-625-S40.jpg","yjhx-40-3-625-S41.jpg","yjhx-40-3-625-S42.jpg","yjhx-40-3-625-S43.jpg","yjhx-40-3-625-S44.jpg","yjhx-40-3-625-S45.jpg"],"firstFig":"yjhx-40-3-625-S1.jpg","fpage":"625","highCitedState":"","htmlCount":89,"htmlFile":"","id":"5d55b38f-b08b-400e-9499-f64ef49f27dd","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"过渡金属催化, 远程meta<\/i>-C—H键, 官能化反应, 配体促进","keywordCn":"过渡金属催化, 远程meta<\/i>-C—H键, 官能化反应, 配体促进","keywordCnList":["过渡金属催化"," 远程meta<\/i>-C—H键"," 官能化反应"," 配体促进"],"keywordEn":"transition metal catalysis, remote meta<\/i>-C—H bond, functionalization, ligand promotion","keywordEnList":["transition metal catalysis"," remote meta<\/i>-C—H bond"," functionalization"," ligand promotion"],"keywordList":["过渡金属催化"," 远程meta<\/i>-C—H键"," 官能化反应"," 配体促进"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"644","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":12,"pdfSize":1012.45,"pubDate":"2020-03-25","recommendState":"","releaseState":"1","secCount":0,"title":"配体促进的过渡金属催化芳烃远程meta<\/i>-C—H键官能化反应研究进展","titleCn":"配体促进的过渡金属催化芳烃远程meta<\/i>-C—H键官能化反应研究进展","titleEn":"Recent Advances in Ligand-Promoted Transition-Metal-Catalyzed Remote meta<\/i>-C—H Functionalization of Arenes","viewCount":384,"volume":"40","year":2020}],"Articles":[{"abstractInfo":"TheC=CdoublebondcleavageofNH2<\/sub>-functionalizedenaminoneshasbeenrealizedatroomtemperaturetoprovidevariousN<\/i>-sulfonylamidinesbyreactingwithsulfonylazides.Thereactionstakeplacewithgoodsubstratetoleranceinthepresenceof1,8-Diazabicyclo[5.4.0]undec-7-ene(DBU)withoutanymetaloroxidantreagent.The15<\/sup>N-labellingexperimentonenaminoneindicatesthatthesulfonylazidecomponentdonatessolelythesulfonamidefragment,andthereactionmechanisminvolvingakeydecompositionoftheinsitu<\/i>generated1,2,3-triazolineintermediateisconvictivelysupported.","abstractInfoCn":"报道了室温条件下烯胺酮和磺酰叠氮通过碳-碳双键断裂合成N<\/i>-磺酰基醚类化合物的方法.反应在1,8-二氮杂双环[5.4.0]十一碳-7-烯(DBU)存在下进行,无需使用任何金属和氧化剂,具有良好的底物适用性.烯胺酮上的15<\/sup>N同位素标记实验证实,磺酰叠氮仅作为产物中的磺酰胺片段供体,同时,该实验也有力地支持反应机理涉及关键的1,2,3-三唑啉中间体的原位形成以及环分解.","abstractInfoEn":"The C=C double bond cleavage of NH2<\/sub>-functionalized enaminones has been realized at room temperature to provide various N<\/i>-sulfonyl amidines by reacting with sulfonyl azides. The reactions take place with good substrate tolerance in the presence of 1, 8-Diazabicyclo[5.4.0]undec-7-ene (DBU) without any metal or oxidant reagent. The 15<\/sup>N-labelling experiment on enaminone indicates that the sulfonyl azide component donates solely the sulfonamide fragment, and the reaction mechanism involving a key decomposition of the in situ<\/i> generated 1, 2, 3-triazoline intermediate is convictively supported.","articleNo":"","authorCnList":["王国栋"," 郭艳辉"," 万结平"],"authorEnList":["Wang Guodong"," Guo Yanhui"," Wan Jieping"],"authorList":["Wang Guodong"," Guo Yanhui"," Wan Jieping"],"authors":"Wang Guodong, Guo Yanhui, Wan Jieping","authorsCn":"王国栋, 郭艳辉, 万结平","authorsEn":"Wang Guodong, Guo Yanhui, Wan Jieping","categoryName":"Articles","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"Wang Guodong, Guo Yanhui, Wan Jieping. Base-Promoted, Metal- and Oxidant-Free C=C Bond Cleavage in Enaminones for Ambient Synthesis of NH2<\/sub>-Amidines. Chinese Journal of Organic Chemistry, 2020, 40(3): 645-650. doi: 10.6023/cjoc201912018.","citationCn":"Wang Guodong, Guo Yanhui, Wan Jieping. 无金属和氧化剂温和条件下碱促进的烯胺酮碳-碳双键断裂合成NH2<\/sub>-结构脒类化合物. 有机化学, 2020, 40(3): 645-650. doi: 10.6023/cjoc201912018.","citationEn":"Wang Guodong, Guo Yanhui, Wan Jieping. Base-Promoted, Metal- and Oxidant-Free C=C Bond Cleavage in Enaminones for Ambient Synthesis of NH2<\/sub>-Amidines. Chinese Journal of Organic Chemistry, 2020, 40(3): 645-650. doi: 10.6023/cjoc201912018.","doi":"10.6023/cjoc201912018","figContent":"yjhx-40-3-645-S1.jpg","figList":["yjhx-40-3-645-S1.jpg"],"firstFig":"yjhx-40-3-645-S1.jpg","fpage":"645","highCitedState":"","htmlCount":57,"htmlFile":"","id":"4d60f808-4e0d-4c04-a1c4-f532f3ea675f","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"Enaminone, C=C bond cleavage, Metal-free, Oxidant-free, Amidines","keywordCn":"烯胺酮, 碳-碳双键断裂, 无金属, 无氧化剂, 脒","keywordCnList":["烯胺酮"," 碳-碳双键断裂"," 无金属"," 无氧化剂"," 脒"],"keywordEn":"Enaminone, C=C bond cleavage, Metal-free, Oxidant-free, Amidines","keywordEnList":["Enaminone"," C=C bond cleavage"," Metal-free"," Oxidant-free"," Amidines"],"keywordList":["Enaminone"," C=C bond cleavage"," Metal-free"," Oxidant-free"," Amidines"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"650","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":10,"pdfSize":477.25,"pubDate":"2020-03-25","recommendState":"","releaseState":"1","secCount":0,"title":"Base-Promoted, Metal- and Oxidant-Free C=C Bond Cleavage in Enaminones for Ambient Synthesis of NH2<\/sub>-Amidines","titleCn":"无金属和氧化剂温和条件下碱促进的烯胺酮碳-碳双键断裂合成NH2<\/sub>-结构脒类化合物","titleEn":"Base-Promoted, Metal- and Oxidant-Free C=C Bond Cleavage in Enaminones for Ambient Synthesis of NH2<\/sub>-Amidines","viewCount":297,"volume":"40","year":2020},{"abstractInfo":"Anickel-catalyzedNegishicouplingofcyclobutanoneoximeesterswitharylzincreagentshasbeendeveloped,inwhichnickelservesbothasaninitiatorforimineradicalsandacatalystforthecouplingofarylzincreagentswithoximeesters.Theprotocolcanavoidtheuseofpoisonouscyanideandhasbroadsubstratescopeaswellasgoodfunctionalgroupcompatibility.Therefore,thismethodprovidesanattractivestrategyforthesynthesisofvaluablenitriles.Preliminarymechanisticstudiesindicatethataradicalpathwayisinvolvedintheproductformation.","abstractInfoCn":"发展了一种镍催化环丁酮肟酯和芳基锌试剂之间Negishi偶联的方法.镍既作为亚胺自由基的引发剂,也作为芳基锌试剂与烷基自由基偶联反应的催化剂在反应中起作用.本方法可避免使用剧毒的氰化物,且具有很广的底物适应性和官能团兼容性,因此可能是一种具有潜在吸引力的高效合成烷基腈类化合物的新策略.初步的机理研究显示,该反应极可能经历自由基历程.","abstractInfoEn":"A nickel-catalyzed Negishi coupling of cyclobutanone oxime esters with aryl zinc reagents has been developed, in which nickel serves both as an initiator for imine radicals and a catalyst for the coupling of aryl zinc reagents with oxime esters. The protocol can avoid the use of poisonous cyanide and has broad substrate scope as well as good functional group compatibility. Therefore, this method provides an attractive strategy for the synthesis of valuable nitriles. Preliminary mechanistic studies indicate that a radical pathway is involved in the product formation.","articleNo":"","authorCnList":["帅斌"," 李兆明"," 裘晖"," 方萍"," 梅天胜"],"authorEnList":["Shuai Bin"," Li Zhao-Ming"," Qiu Hui"," Fang Ping"," Mei Tian-Sheng"],"authorList":["Shuai Bin"," Li Zhao-Ming"," Qiu Hui"," Fang Ping"," Mei Tian-Sheng"],"authors":"Shuai Bin, Li Zhao-Ming, Qiu Hui, Fang Ping, Mei Tian-Sheng","authorsCn":"帅斌, 李兆明, 裘晖, 方萍, 梅天胜","authorsEn":"Shuai Bin, Li Zhao-Ming, Qiu Hui, Fang Ping, Mei Tian-Sheng","categoryName":"Articles","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"Shuai Bin, Li Zhao-Ming, Qiu Hui, Fang Ping, Mei Tian-Sheng. Nickel-Catalyzed Negishi Coupling of Cyclobutanone Oxime Esters with Aryl Zinc Reagents. Chinese Journal of Organic Chemistry, 2020, 40(3): 651-662. doi: 10.6023/cjoc201911016.","citationCn":"Shuai Bin, Li Zhao-Ming, Qiu Hui, Fang Ping, Mei Tian-Sheng. 镍催化环丁酮肟酯与芳基锌试剂的Negishi偶联反应. 有机化学, 2020, 40(3): 651-662. doi: 10.6023/cjoc201911016.","citationEn":"Shuai Bin, Li Zhao-Ming, Qiu Hui, Fang Ping, Mei Tian-Sheng. Nickel-Catalyzed Negishi Coupling of Cyclobutanone Oxime Esters with Aryl Zinc Reagents. Chinese Journal of Organic Chemistry, 2020, 40(3): 651-662. doi: 10.6023/cjoc201911016.","doi":"10.6023/cjoc201911016","figContent":"yjhx-40-3-651-S1.jpg$$yjhx-40-3-651-S2.jpg$$yjhx-40-3-651-S3.jpg","figList":["yjhx-40-3-651-S1.jpg","yjhx-40-3-651-S2.jpg","yjhx-40-3-651-S3.jpg"],"firstFig":"yjhx-40-3-651-S1.jpg","fpage":"651","highCitedState":"","htmlCount":56,"htmlFile":"","id":"4c678b38-5bb8-4935-9010-805221d8effe","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"Negishi coupling, nickel, cyclobutanone oxime esters, aryl zinc reagents","keywordCn":"Negishi偶联, 镍, 环丁酮肟酯, 芳基锌试剂","keywordCnList":["Negishi偶联"," 镍"," 环丁酮肟酯"," 芳基锌试剂"],"keywordEn":"Negishi coupling, nickel, cyclobutanone oxime esters, aryl zinc reagents","keywordEnList":["Negishi coupling"," nickel"," cyclobutanone oxime esters"," aryl zinc reagents"],"keywordList":["Negishi coupling"," nickel"," cyclobutanone oxime esters"," aryl zinc reagents"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"662","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":13,"pdfSize":561.12,"pubDate":"2020-03-25","recommendState":"","releaseState":"1","secCount":0,"title":"Nickel-Catalyzed Negishi Coupling of Cyclobutanone Oxime Esters with Aryl Zinc Reagents","titleCn":"镍催化环丁酮肟酯与芳基锌试剂的Negishi偶联反应","titleEn":"Nickel-Catalyzed Negishi Coupling of Cyclobutanone Oxime Esters with Aryl Zinc Reagents","viewCount":283,"volume":"40","year":2020},{"abstractInfo":"TheRu(Ⅱ)-catalyzedregioselective[4+1]cycloadditionofazobenzeneswithethylglyoxalatethroughC-Hbondactivationhasbeendeveloped.Thismethodprovidesafacileapproachtovarious3-carboxylateindazolesinmoderatetogoodyields.Meantime,thekineticisotopeeffectwasfurtherinvestigatedandtheresultsindicatedthattheC-Hbond-breakingwaspossiblynotinvolvedintherate-limitingstepofthistransformation.","abstractInfoCn":"报道了一种简便有效的Ru(II)催化偶氮苯与乙醛酸乙酯的高选择性[4+1]环化反应,该反应历程涉及C—H键的活化.这种策略能够以中等至良好的产率去高效构建多样性的吲唑骨架结构.同时研究了该反应的动力学同位素效应,实验结果表明C—H键活化可能不属于整个反应历程的决速步骤.","abstractInfoEn":"The Ru(Ⅱ)-catalyzed regioselective[4+1] cycloaddition of azobenzenes with ethyl glyoxalate through C-H bond activation has been developed. This method provides a facile approach to various 3-carboxylate indazoles in moderate to good yields. Meantime, the kinetic isotope effect was further investigated and the results indicated that the C-H bond-breaking was possibly not involved in the rate-limiting step of this transformation.","articleNo":"","authorCnList":["陈训"," 王颖"," 王烁今"," 孔杜林"," 文丽君"," 翟锐锐"," 赵珂"," 白丽丽"," 李友宾"],"authorEnList":["Chen Xun"," Wang Ying"," Wang Shuojin"," Kong Dulin"," Wen Lijun"," Zhai Ruirui"," Zhao Ke"," Bai Lili"," Li Youbin"],"authorList":["Chen Xun"," Wang Ying"," Wang Shuojin"," Kong Dulin"," Wen Lijun"," Zhai Ruirui"," Zhao Ke"," Bai Lili"," Li Youbin"],"authors":"Chen Xun, Wang Ying, Wang Shuojin, Kong Dulin, Wen Lijun, Zhai Ruirui, Zhao Ke, Bai Lili, Li Youbin","authorsCn":"陈训, 王颖, 王烁今, 孔杜林, 文丽君, 翟锐锐, 赵珂, 白丽丽, 李友宾","authorsEn":"Chen Xun, Wang Ying, Wang Shuojin, Kong Dulin, Wen Lijun, Zhai Ruirui, Zhao Ke, Bai Lili, Li Youbin","categoryName":"Articles","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"Chen Xun, Wang Ying, Wang Shuojin, Kong Dulin, Wen Lijun, Zhai Ruirui, Zhao Ke, Bai Lili, Li Youbin. Synthesis of 3-Carboxylate Indazoles via Ru(Ⅱ)-Catalyzed Annulation of Azobenzenes with Ethyl Glyoxalate. Chinese Journal of Organic Chemistry, 2020, 40(3): 688-693. doi: 10.6023/cjoc201909021.","citationCn":"Chen Xun, Wang Ying, Wang Shuojin, Kong Dulin, Wen Lijun, Zhai Ruirui, Zhao Ke, Bai Lili, Li Youbin. 钌(Ⅱ)-催化偶氮苯与乙醛酸乙酯的环化反应构建3-羧酸酯吲唑. 有机化学, 2020, 40(3): 688-693. doi: 10.6023/cjoc201909021.","citationEn":"Chen Xun, Wang Ying, Wang Shuojin, Kong Dulin, Wen Lijun, Zhai Ruirui, Zhao Ke, Bai Lili, Li Youbin. Synthesis of 3-Carboxylate Indazoles via Ru(Ⅱ)-Catalyzed Annulation of Azobenzenes with Ethyl Glyoxalate. Chinese Journal of Organic Chemistry, 2020, 40(3): 688-693. doi: 10.6023/cjoc201909021.","doi":"10.6023/cjoc201909021","figContent":"yjhx-40-3-688-1.jpg$$yjhx-40-3-688-S1.jpg$$yjhx-40-3-688-S2.jpg$$yjhx-40-3-688-S3.jpg","figList":["yjhx-40-3-688-1.jpg","yjhx-40-3-688-S1.jpg","yjhx-40-3-688-S2.jpg","yjhx-40-3-688-S3.jpg"],"firstFig":"yjhx-40-3-688-1.jpg","fpage":"688","highCitedState":"","htmlCount":5,"htmlFile":"","id":"267b0ea6-a90e-454d-b6b5-7325eb3709d4","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"Ru (Ⅱ), C—H bond activation, cycloaddition, Indazoles","keywordCn":"钌(Ⅱ), C—H键活化, 环化反应, 吲唑","keywordCnList":["钌(Ⅱ)"," C—H键活化"," 环化反应"," 吲唑"],"keywordEn":"Ru (Ⅱ), C—H bond activation, cycloaddition, Indazoles","keywordEnList":["Ru (Ⅱ)"," C—H bond activation"," cycloaddition"," Indazoles"],"keywordList":["Ru (Ⅱ)"," C—H bond activation"," cycloaddition"," Indazoles"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"693","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":6,"pdfSize":495.4,"pubDate":"2020-03-01","recommendState":"","releaseState":"1","secCount":0,"title":"Synthesis of 3-Carboxylate Indazoles via Ru(Ⅱ)-Catalyzed Annulation of Azobenzenes with Ethyl Glyoxalate","titleCn":"钌(Ⅱ)-催化偶氮苯与乙醛酸乙酯的环化反应构建3-羧酸酯吲唑","titleEn":"Synthesis of 3-Carboxylate Indazoles via Ru(Ⅱ)-Catalyzed Annulation of Azobenzenes with Ethyl Glyoxalate","viewCount":143,"volume":"40","year":2020},{"abstractInfo":"Thecatalyst-freedominoreactionofethyl4-hydroxyalkyl-2-ynoateandN<\/i>-heteroaryl-methyl-N<\/i>-2,2-difluoroethan-1-aminewasdeveloped,andusedtosynthesize4-(N<\/i>-(2,2-difluoroethyl)(N<\/i>-heteroarylmethyl)amino)-5,5-disubstitutedfuran-2(5H<\/i>)-oneinmethanolundertherefluxconditionwithyieldsof39%~83%.Theirstructureswerecharacterizedby1<\/sup>HNMR,13<\/sup>CNMR,andHR-ESI-MSdata,furtherconfirmedbytheX-raycrystaldiffractionof3-chloro-4-((N<\/i>-2,2-difluoroethyl)(N<\/i>-pyrimidin-5-ylmethyl)amino)-5,5-spiro(4-methoxycyclohexyl)furan-2(5H<\/i>)-one(8<\/b>).Thebioassayresultsshowedthat4-((N<\/i>-2,2-difluoroethyl)(N<\/i>-6-chloropyridin-3-ylmethyl)amino)-5,5-dimethylfuran-2(5H<\/i>)-one(3a<\/b>)and4-((N<\/i>-2,2-difluoroethyl)(N<\/i>-6-fluoropyridin-3-ylmethyl)-amino)-5,5-dimethylfuran-2(5H<\/i>)-one(3c<\/b>)exhibit100%mortalityagainstMyzus<\/i>persicae<\/i>attheconcentrationof600μg·mL-1<\/sup>,respectively.","abstractInfoCn":"开发了无催化剂条件下4-羟基烷基-2-炔酸乙酯与N<\/i>-杂环芳基甲基-N<\/i>-2,2-二氟乙基-1-胺的串联反应.应用该反应在甲醇中回流,以39%~83%的收率合成了一系列4-(N<\/i>-(2,2-二氟乙基)(N<\/i>-杂环芳基甲基)氨基)-5,5-二取代呋喃-2(5H<\/i>)-酮,其结构经1<\/sup>H NMR,13<\/sup>C NMR和HR-ESI-MS表征,并进一步通过3-氯-4-((N-2,2-二氟乙基)(N-嘧啶-5-基甲基胺基)-5,5-螺(4-甲氧基环己基)呋喃-2(5H<\/i>)-酮(8<\/b>)的晶体衍射间接证实.测试了所合成化合物的生物活性,结果表明,在600 μg·mL-1<\/sup>浓度时4-((N<\/i>-2,2-二氟乙基)(N<\/i>-6-氯吡啶-3-基甲基胺基)-5,5-二甲基呋喃-2(5H<\/i>)-酮(3a<\/b>)和4-((N<\/i>-2,2-二氟乙基)(N<\/i>-6-氟吡啶-3-基甲基胺基)-5,5-二甲基呋喃-2(5H<\/i>)-酮(3c<\/b>)对桃蚜的死亡率均为100%.","abstractInfoEn":"The catalyst-free domino reaction of ethyl 4-hydroxyalkyl-2-ynoate and N<\/i>-heteroaryl-methyl-N<\/i>-2, 2-difluoroethan-1-amine was developed, and used to synthesize 4-(N<\/i>-(2, 2-difluoroethyl)(N<\/i>-heteroarylmethyl)amino)-5, 5-disubstitutedfuran-2(5H<\/i>)-one in methanol under the reflux condition with yields of 39%~83%. Their structures were characterized by 1<\/sup>H NMR, 13<\/sup>C NMR, and HR-ESI-MS data, further confirmed by the X-ray crystal diffraction of 3-chloro-4-((N<\/i>-2, 2-difluoroethyl)(N<\/i>-pyrimidin-5-ylmethyl)amino)-5, 5-spiro(4-methoxycyclohexyl)furan-2(5H<\/i>)-one (8<\/b>). The bioassay results showed that 4-((N<\/i>-2, 2-difluoroethyl)(N<\/i>-6-chloropyridin-3-ylmethyl)amino)-5, 5-dimethylfuran-2(5H<\/i>)-one (3a<\/b>) and 4-((N<\/i>-2, 2-difluoroethyl)(N<\/i>-6-fluoropyridin-3-ylmethyl)-amino)-5, 5-dimethylfuran-2(5H<\/i>)-one (3c<\/b>) exhibit 100% mortality against Myzus<\/i> persicae<\/i> at the concentration of 600 μg·mL-1<\/sup>, respectively.","articleNo":"","authorCnList":["赵宇"," 王卫伟"," 刘鑫磊"," 耿瑞"," 王明安"],"authorEnList":["Zhao Yu"," Wang Weiwei"," Liu Xinlei"," Geng Rui"," Wang Ming'an"],"authorList":["Zhao Yu"," Wang Weiwei"," Liu Xinlei"," Geng Rui"," Wang Ming'an"],"authors":"Zhao Yu, Wang Weiwei, Liu Xinlei, Geng Rui, Wang Ming'an","authorsCn":"赵宇, 王卫伟, 刘鑫磊, 耿瑞, 王明安","authorsEn":"Zhao Yu, Wang Weiwei, Liu Xinlei, Geng Rui, Wang Ming'an","categoryName":"Articles","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"Zhao Yu, Wang Weiwei, Liu Xinlei, Geng Rui, Wang Ming'an. Catalyst-Free Domino Reaction of Ethyl 4-Hydroxyalkyl-2-ynoate with N<\/i>-Heteroarylmethyl-N<\/i>-2, 2-difluoroethan-1-amine. Chinese Journal of Organic Chemistry, 2020, 40(3): 694-703. doi: 10.6023/cjoc201909009.","citationCn":"Zhao Yu, Wang Weiwei, Liu Xinlei, Geng Rui, Wang Ming'an. 无催化剂条件下4-羟基烷基-2-炔酸乙酯与N<\/i>-杂环芳基甲基-N<\/i>-2, 2-二氟乙基-1-胺的串联反应. 有机化学, 2020, 40(3): 694-703. doi: 10.6023/cjoc201909009.","citationEn":"Zhao Yu, Wang Weiwei, Liu Xinlei, Geng Rui, Wang Ming'an. Catalyst-Free Domino Reaction of Ethyl 4-Hydroxyalkyl-2-ynoate with N<\/i>-Heteroarylmethyl-N<\/i>-2, 2-difluoroethan-1-amine. Chinese Journal of Organic Chemistry, 2020, 40(3): 694-703. doi: 10.6023/cjoc201909009.","doi":"10.6023/cjoc201909009","figContent":"yjhx-40-3-694-1.jpg$$yjhx-40-3-694-S1.jpg$$yjhx-40-3-694-S2.jpg$$yjhx-40-3-694-S3.jpg$$yjhx-40-3-694-2.jpg","figList":["yjhx-40-3-694-1.jpg","yjhx-40-3-694-S1.jpg","yjhx-40-3-694-S2.jpg","yjhx-40-3-694-S3.jpg","yjhx-40-3-694-2.jpg"],"firstFig":"yjhx-40-3-694-1.jpg","fpage":"694","highCitedState":"","htmlCount":5,"htmlFile":"","id":"a667e0d6-ab4e-4ce1-8ca5-4f297c9e0c0d","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"5, 5-disubstitutedfuran-2(5H<\/i>)-one, domino reaction, addition-lactonization, insecticidal activity","keywordCn":"5, 5-二取代呋喃-2(5H<\/i>)-酮, 串联反应, 加成-内酯化反应, 杀虫活性","keywordCnList":["5"," 5-二取代呋喃-2(5H<\/i>)-酮"," 串联反应"," 加成-内酯化反应"," 杀虫活性"],"keywordEn":"5, 5-disubstitutedfuran-2(5H<\/i>)-one, domino reaction, addition-lactonization, insecticidal activity","keywordEnList":["5"," 5-disubstitutedfuran-2(5H<\/i>)-one"," domino reaction"," addition-lactonization"," insecticidal activity"],"keywordList":["5"," 5-disubstitutedfuran-2(5H<\/i>)-one"," domino reaction"," addition-lactonization"," insecticidal activity"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"703","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":3,"pdfSize":615.65,"pubDate":"2020-03-01","recommendState":"","releaseState":"1","secCount":0,"title":"Catalyst-Free Domino Reaction of Ethyl 4-Hydroxyalkyl-2-ynoate with N<\/i>-Heteroarylmethyl-N<\/i>-2, 2-difluoroethan-1-amine","titleCn":"无催化剂条件下4-羟基烷基-2-炔酸乙酯与N<\/i>-杂环芳基甲基-N<\/i>-2, 2-二氟乙基-1-胺的串联反应","titleEn":"Catalyst-Free Domino Reaction of Ethyl 4-Hydroxyalkyl-2-ynoate with N<\/i>-Heteroarylmethyl-N<\/i>-2, 2-difluoroethan-1-amine","viewCount":162,"volume":"40","year":2020},{"abstractInfo":"Thecobalt-catalyzedregioselectiveC-Halkoxylationof1-naphthylamidewithalcoholsthroughabidentate-chelationassistancehasbeendeveloped.Inthistransformation,notonlyprimaryandsecondaryalcohols,butalsoaliphaticdiolsandoligoethyleneglycols,whichalwaysbeemployedasO,O-donorligandsandreducingagentsintransitionmetalcatalyzedcouplingreaction,werealltoleratedundercurrentreactionconditions.Itisnoteworthythatdeuteriumlabeled8-alkoxyl-1-N<\/i>-(naphthalen-1-yl)picolinamidederivativewaseasilyachievedunderthiscatalyticsystem.Inaddition,controlexperimentssuggestedthatpicolinoylwasthekeydirectinggroup,andfurthermore,theC(8)-Halkoxylationreactionmightproceedthroughasingle-electron-transfer(SET)process.","abstractInfoCn":"研究了吡啶酰胺双齿导向的钴催化1-萘胺衍生物的区域选择性碳氢键烷氧基化反应.研究发现不仅一元醇可以作为烷氧化剂在标准条件下较好地实现1-萘胺C(8)位的烷氧化反应,而且具有多重用途的脂肪二元醇以及低聚乙二醇,也可以以中等的收率得到相应的目标化合物,这可能是钴催化碳氢键活化构筑碳氧键的首次发现.此外,利用这个实验方法,以氘代甲醇为烷氧化试剂实现了同位素标记的8-烷氧基取代的1-萘胺衍生物的合成.通过控制实验,发现该反应中吡啶酰基是最佳的双导向基团,而且反应过程可能经历了单电子转移机理.","abstractInfoEn":"The cobalt-catalyzed regioselective C-H alkoxylation of 1-naphthylamide with alcohols through a bidentate-chelation assistance has been developed. In this transformation, not only primary and secondary alcohols, but also aliphatic diols and oligoethylene glycols, which always be employed as O, O-donor ligands and reducing agents in transition metal catalyzed coupling reaction, were all tolerated under current reaction conditions. It is noteworthy that deuterium labeled 8-alkoxyl-1-N<\/i>-(naphthalen-1-yl)picolinamide derivative was easily achieved under this catalytic system. In addition, control experiments suggested that picolinoyl was the key directing group, and furthermore, the C(8)-H alkoxylation reaction might proceed through a single-electron-transfer (SET) process.","articleNo":"","authorCnList":["张梦帆"," 李瑞鹏"," 杨震"," 冯若昆"],"authorEnList":["Zhang Mengfan"," Li Ruipeng"," Yang Zhen"," Feng Ruokun"],"authorList":["Zhang Mengfan"," Li Ruipeng"," Yang Zhen"," Feng Ruokun"],"authors":"Zhang Mengfan, Li Ruipeng, Yang Zhen, Feng Ruokun","authorsCn":"张梦帆, 李瑞鹏, 杨震, 冯若昆","authorsEn":"Zhang Mengfan, Li Ruipeng, Yang Zhen, Feng Ruokun","categoryName":"Articles","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"Zhang Mengfan, Li Ruipeng, Yang Zhen, Feng Ruokun. Cobalt-Catalyzed Bidentate-Assisted Regioselective C—H Alkoxylation of 1-Naphthylamide with Alcohols. Chinese Journal of Organic Chemistry, 2020, 40(3): 714-723. doi: 10.6023/cjoc201908040.","citationCn":"Zhang Mengfan, Li Ruipeng, Yang Zhen, Feng Ruokun. 钴催化双齿导向基辅助的1-萘胺衍生物与醇的区域选择性碳氢键烷氧基化反应. 有机化学, 2020, 40(3): 714-723. doi: 10.6023/cjoc201908040.","citationEn":"Zhang Mengfan, Li Ruipeng, Yang Zhen, Feng Ruokun. Cobalt-Catalyzed Bidentate-Assisted Regioselective C—H Alkoxylation of 1-Naphthylamide with Alcohols. Chinese Journal of Organic Chemistry, 2020, 40(3): 714-723. doi: 10.6023/cjoc201908040.","doi":"10.6023/cjoc201908040","figContent":"yjhx-40-3-714-S1.jpg$$yjhx-40-3-714-S2.jpg$$yjhx-40-3-714-S3.jpg","figList":["yjhx-40-3-714-S1.jpg","yjhx-40-3-714-S2.jpg","yjhx-40-3-714-S3.jpg"],"firstFig":"yjhx-40-3-714-S1.jpg","fpage":"714","highCitedState":"","htmlCount":10,"htmlFile":"","id":"c14f791e-3ee0-43f8-a105-ee7c910974ff","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"cobalt-catalyzed, bidentate-assisted, 1-naphthylamide, C (8)-alkoxylation, regioselectivity","keywordCn":"钴催化, 双导向, 1-萘胺, C (8)-烷氧化, 区域选择性","keywordCnList":["钴催化"," 双导向"," 1-萘胺"," C (8)-烷氧化"," 区域选择性"],"keywordEn":"cobalt-catalyzed, bidentate-assisted, 1-naphthylamide, C (8)-alkoxylation, regioselectivity","keywordEnList":["cobalt-catalyzed"," bidentate-assisted"," 1-naphthylamide"," C (8)-alkoxylation"," regioselectivity"],"keywordList":["cobalt-catalyzed"," bidentate-assisted"," 1-naphthylamide"," C (8)-alkoxylation"," regioselectivity"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"723","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":3,"pdfSize":678.12,"pubDate":"2020-03-01","recommendState":"","releaseState":"1","secCount":0,"title":"Cobalt-Catalyzed Bidentate-Assisted Regioselective C—H Alkoxylation of 1-Naphthylamide with Alcohols","titleCn":"钴催化双齿导向基辅助的1-萘胺衍生物与醇的区域选择性碳氢键烷氧基化反应","titleEn":"Cobalt-Catalyzed Bidentate-Assisted Regioselective C—H Alkoxylation of 1-Naphthylamide with Alcohols","viewCount":161,"volume":"40","year":2020},{"abstractInfo":"AhighlyefficientandregioselectiveC-3-alkylationof2-arylindoleswithmaleimideshasbeendevelopedusingAg(I)ascatalyst.3-(2-Aryl-1H<\/i>-indol-3-yl)pyrrolidine-2,5-dioneswereaffordedwithhighyields(upto97%)underrelativelymildreactionconditions.Themethodfeaturesoperationalsimplicityandavoidingexternaloxidant.","abstractInfoCn":"发展了一种银催化高效高区域选择性的2-芳基吲哚C-3位烷基化反应.在温和条件下,能以高达97%的收率得到目标化合物,且该方法操作简单,不需要外加氧化剂.","abstractInfoEn":"A highly efficient and regioselective C-3-alkylation of 2-arylindoles with maleimides has been developed using Ag(I) as catalyst. 3-(2-Aryl-1H<\/i>-indol-3-yl)pyrrolidine-2, 5-diones were afforded with high yields (up to 97%) under relatively mild reaction conditions. The method features operational simplicity and avoiding external oxidant.","articleNo":"","authorCnList":["皮超"," 曲亚平"," 崔秀灵"," 吴养洁"],"authorEnList":["Pi Chao"," Qu Yaping"," Cui Xiuling"," Wu Yangjie"],"authorList":["Pi Chao"," Qu Yaping"," Cui Xiuling"," Wu Yangjie"],"authors":"Pi Chao, Qu Yaping, Cui Xiuling, Wu Yangjie","authorsCn":"皮超, 曲亚平, 崔秀灵, 吴养洁","authorsEn":"Pi Chao, Qu Yaping, Cui Xiuling, Wu Yangjie","categoryName":"Articles","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"Pi Chao, Qu Yaping, Cui Xiuling, Wu Yangjie. Silver-Catalyzed C—H Alkylation of 2-Arylindoles with Maleimides. Chinese Journal of Organic Chemistry, 2020, 40(3): 740-747. doi: 10.6023/cjoc201907040.","citationCn":"Pi Chao, Qu Yaping, Cui Xiuling, Wu Yangjie. 银催化2-芳基吲哚与马来酰亚胺C—H键烷基化反应. 有机化学, 2020, 40(3): 740-747. doi: 10.6023/cjoc201907040.","citationEn":"Pi Chao, Qu Yaping, Cui Xiuling, Wu Yangjie. Silver-Catalyzed C—H Alkylation of 2-Arylindoles with Maleimides. Chinese Journal of Organic Chemistry, 2020, 40(3): 740-747. doi: 10.6023/cjoc201907040.","doi":"10.6023/cjoc201907040","figContent":"yjhx-40-3-740-1.jpg$$yjhx-40-3-740-2.jpg$$yjhx-40-3-740-S1.jpg$$yjhx-40-3-740-3.jpg","figList":["yjhx-40-3-740-1.jpg","yjhx-40-3-740-2.jpg","yjhx-40-3-740-S1.jpg","yjhx-40-3-740-3.jpg"],"firstFig":"yjhx-40-3-740-1.jpg","fpage":"740","highCitedState":"","htmlCount":24,"htmlFile":"","id":"a2f0bcb1-7e03-429d-81b6-e8a48446f99f","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"silver-catalyzed, 2-arylindoles, maleimides, alkylation","keywordCn":"银催化, 2-芳基吲哚, 马来酰亚胺, 烷基化","keywordCnList":["银催化"," 2-芳基吲哚"," 马来酰亚胺"," 烷基化"],"keywordEn":"silver-catalyzed, 2-arylindoles, maleimides, alkylation","keywordEnList":["silver-catalyzed"," 2-arylindoles"," maleimides"," alkylation"],"keywordList":["silver-catalyzed"," 2-arylindoles"," maleimides"," alkylation"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"747","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":6,"pdfSize":578.3,"pubDate":"2020-03-01","recommendState":"","releaseState":"1","secCount":0,"title":"Silver-Catalyzed C—H Alkylation of 2-Arylindoles with Maleimides","titleCn":"银催化2-芳基吲哚与马来酰亚胺C—H键烷基化反应","titleEn":"Silver-Catalyzed C—H Alkylation of 2-Arylindoles with Maleimides","viewCount":225,"volume":"40","year":2020},{"abstractInfo":"FourD-A-D-A-Dstructuredorganicsmallmolecules(OSMs)DOBT-8T<\/b>,BT-8T<\/b>,FBT-8T<\/b>andFFBT-8T<\/b>havebeendesignedfororganicsolarcells,whichcontaintetrathiopheneasthecoredonorunit,bithiopheneasthetermialdonorunit,combiningdifferentelectron-withdrawingfragmentsDOBT,BT,FBTandFFBTasacceptorunit,respectively.ThedesignedfourOSMswereanalyzedusingdensityfunctionaltheory(DFT)andtimedependent-DFT(TDDFT)calculationsatB3LYP/6-31G(d)level.Theeffectsofstructuremodificationofbenzothiadiazoleacceptorunitonmodulatingtheelectron-donatingabilityofOSMswerefullyinvestigated.Resultsshowedthatthegeometricalstructure,theband-gap,HOMO/LUMOenergylevels,orbitalspatialdistribution,energeticdrivingforce,open-circuitvoltageandNPAatomicchargeoftheseOSMscanbesystematicallyalteredbyvaryingtheelectron-withdrawingpropertieswithdifferentbenzothiadiazoleacceptorunits.ComparedtootherOSMs,FBT-8T<\/b>displayedthemorenarrowedE<\/i>g<\/sub>andrelativelydeeperHOMOlevelwithFBTasacceptor.FFBT-8T<\/b>exhibitedthemostdeep-lyingHOMOlevelofthefourdesignedOSMsandsuitableE<\/i>g<\/sub>valuebyusingFFBTasacceptor.Thepowerconversionefficiencies(PCEs)ofca.<\/i>4.7%andca.<\/i>5.2%wereachievedbythephotovoltaicdevicesbasedonFBT-8T:PC61<\/sub>BMandFFBT-8T:PC61<\/sub>BMsystems,respectively,predictingwithScharbermodels.Onthebasisoftheseresults,FBT-8T<\/b>andFFBT-8T<\/b>aspotentialOSMsdonormaterialsforhigh-efficiencyorganicbulkhetero-junctionsolarcellwereproposed.","abstractInfoCn":"设计了四个以四联噻吩为中心给电子单元,联二噻吩为末端给电子单元,不同功能的苯并噻二唑(DOBT,BT,FBT和FFBT)为吸电子单元的有机小分子太阳能电池给体材料,分别称为DOBT-8T<\/b>,BT-8T<\/b>,FBT-8T<\/b>和FFBT-8T<\/b>.在B3LYP/6-31G(d)基组的水平上利用密度泛函和含时密度泛函理论对四个小分子进行了理论计算.详细分析了吸电子单元苯并噻二唑的结构修饰对小分子给体材料性能的影响.理论计算结果显示,不同功能的苯并噻二唑单元的引入对小分子给体材料的几何结构、禁带宽度、HOMO与LUMO能级、轨道电子密度分配、能量驱动力、开路电压和分子中的原子电荷(NPA)都有重要调节作用.相比于其它分子,以FBT为吸电子单元的FBT-8T<\/b>,显示了最窄的带隙和较低的HOMO能级值.以FFBT为吸电子单元的FFBT-8T<\/b>,获得了最低的HOMO能级和较为合适的禁带宽度.利用Scharber模型分别计算了基于小分子/PC61<\/sub>BM为活性层的光伏器件的能量转换效率(PCE),基于FBT-8T<\/b>/PC61<\/sub>BM和FFBT-8T<\/b>/PC61<\/sub>BM的光伏器件,将获得的PCE分别高达约4.7%和5.2%.在以上研究的基础上,推测FBT-8T<\/b>和FFBT-8T<\/b>是潜在的高性能的有机小分子体异质结光伏给体材料.","abstractInfoEn":"Four D-A-D-A-D structured organic small molecules (OSMs) DOBT-8T<\/b>, BT-8T<\/b>, FBT-8T<\/b> and FFBT-8T<\/b> have been designed for organic solar cells, which contain tetrathiophene as the core donor unit, bithiophene as the termial donor unit, combining different electron-withdrawing fragments DOBT, BT, FBT and FFBT as acceptor unit, respectively. The designed four OSMs were analyzed using density functional theory (DFT) and time dependent-DFT (TDDFT) calculations at B3LYP/6-31G(d) level. The effects of structure modification of benzothiadiazole acceptor unit on modulating the electron-donating ability of OSMs were fully investigated. Results showed that the geometrical structure, the band-gap, HOMO/LUMO energy levels, orbital spatial distribution, energetic driving force, open-circuit voltage and NPA atomic charge of these OSMs can be systematically altered by varying the electron-withdrawing properties with different benzothiadiazole acceptor units. Compared to other OSMs, FBT-8T<\/b> displayed the more narrowed E<\/i>g<\/sub> and relatively deeper HOMO level with FBT as acceptor. FFBT-8T<\/b> exhibited the most deep-lying HOMO level of the four designed OSMs and suitable E<\/i>g<\/sub> value by using FFBT as acceptor. The power conversion efficiencies (PCEs) of ca.<\/i> 4.7% and ca.<\/i> 5.2% were achieved by the photovoltaic devices based on FBT-8T:PC61<\/sub>BM and FFBT-8T:PC61<\/sub>BM systems, respectively, predicting with Scharber models. On the basis of these results, FBT-8T<\/b> and FFBT-8T<\/b> as potential OSMs donor materials for high-efficiency organic bulk hetero-junction solar cell were proposed.","articleNo":"","authorCnList":["王丽辉"," 白锁柱"," 李东勇"," 周宏"],"authorEnList":["Wang Lihui"," Bai Suozhu"," Li Dongyong"," Zhou Hong"],"authorList":["Wang Lihui"," Bai Suozhu"," Li Dongyong"," Zhou Hong"],"authors":"Wang Lihui, Bai Suozhu, Li Dongyong, Zhou Hong","authorsCn":"王丽辉, 白锁柱, 李东勇, 周宏","authorsEn":"Wang Lihui, Bai Suozhu, Li Dongyong, Zhou Hong","categoryName":"Articles","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"Wang Lihui, Bai Suozhu, Li Dongyong, Zhou Hong. Effect of Structure Modification of Benzothiadiazole Acceptor Unit on the D-A-D-A-D Typed Oligothiophene Based Donor Materials for Organic Small Molecules Solar Cells: A Theoretical Study. Chinese Journal of Organic Chemistry, 2020, 40(3): 748-755. doi: 10.6023/cjoc201907032.","citationCn":"Wang Lihui, Bai Suozhu, Li Dongyong, Zhou Hong. 基于不同功能的苯并噻二唑为受体单元和低聚噻吩为给体单元的D-A-D-A-D型有机小分子光伏材料的理论计算研究. 有机化学, 2020, 40(3): 748-755. doi: 10.6023/cjoc201907032.","citationEn":"Wang Lihui, Bai Suozhu, Li Dongyong, Zhou Hong. Effect of Structure Modification of Benzothiadiazole Acceptor Unit on the D-A-D-A-D Typed Oligothiophene Based Donor Materials for Organic Small Molecules Solar Cells: A Theoretical Study. Chinese Journal of Organic Chemistry, 2020, 40(3): 748-755. doi: 10.6023/cjoc201907032.","doi":"10.6023/cjoc201907032","figContent":"yjhx-40-3-748-1.jpg$$yjhx-40-3-748-2.jpg$$yjhx-40-3-748-3.jpg$$yjhx-40-3-748-4.jpg$$yjhx-40-3-748-5.jpg","figList":["yjhx-40-3-748-1.jpg","yjhx-40-3-748-2.jpg","yjhx-40-3-748-3.jpg","yjhx-40-3-748-4.jpg","yjhx-40-3-748-5.jpg"],"firstFig":"yjhx-40-3-748-1.jpg","fpage":"748","highCitedState":"","htmlCount":18,"htmlFile":"","id":"2f7ed738-b9d0-491e-ab5f-a55330eb40f7","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"B3LYP/6-31G (d), donor, OSMs, organic solar cell, benzothiadiazole, oligothiophenes","keywordCn":"B3LYP/6-31G (d), 给体材料, 小分子, 有机太阳能电池, 苯并噻二唑, 低聚噻吩","keywordCnList":["B3LYP/6-31G (d)"," 给体材料"," 小分子"," 有机太阳能电池"," 苯并噻二唑"," 低聚噻吩"],"keywordEn":"B3LYP/6-31G (d), donor, OSMs, organic solar cell, benzothiadiazole, oligothiophenes","keywordEnList":["B3LYP/6-31G (d)"," donor"," OSMs"," organic solar cell"," benzothiadiazole"," oligothiophenes"],"keywordList":["B3LYP/6-31G (d)"," donor"," OSMs"," organic solar cell"," benzothiadiazole"," oligothiophenes"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"755","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":2,"pdfSize":4457.65,"pubDate":"2020-03-25","recommendState":"","releaseState":"1","secCount":0,"title":"Effect of Structure Modification of Benzothiadiazole Acceptor Unit on the D-A-D-A-D Typed Oligothiophene Based Donor Materials for Organic Small Molecules Solar Cells: A Theoretical Study","titleCn":"基于不同功能的苯并噻二唑为受体单元和低聚噻吩为给体单元的D-A-D-A-D型有机小分子光伏材料的理论计算研究","titleEn":"Effect of Structure Modification of Benzothiadiazole Acceptor Unit on the D-A-D-A-D Typed Oligothiophene Based Donor Materials for Organic Small Molecules Solar Cells: A Theoretical Study","viewCount":206,"volume":"40","year":2020}],"研究论文":[{"abstractInfo":"利用核磁实验,研究了并入四个磺酸根或羧酸根的高水溶性开环葫芦脲对疏水性芳烃和芳醛的水相增溶作用.并入四个磺酸根的开环葫芦脲acCB-1<\/b>能显著提高包括三联苯、4,4'-二甲基联苯和联苯-4,4'-二甲醛在内的芳烃和芳醛的水溶性,其中4,4'-二甲基联苯的溶解度可以提高到8.9mmol/L,联苯-4,4'-二甲醛的溶解度可以提高到11.2mmol/L.并入四个羧酸根的acCB-2<\/b>可以把五氟甲苯和六氟苯在水中的溶解度提高到5.6和3.0mmol/L.acCB-1<\/b>还可以通过增溶芳香醛,促进其与酰肼反应形成腙.这一促进作用可以进一步应用于促进两个芳香二醛和一个芳香二酰肼在水中的反应,制备常规条件下不能形成的两个芳香腙大环.","abstractInfoCn":"利用核磁实验,研究了并入四个磺酸根或羧酸根的高水溶性开环葫芦脲对疏水性芳烃和芳醛的水相增溶作用.并入四个磺酸根的开环葫芦脲acCB-1<\/b>能显著提高包括三联苯、4,4'-二甲基联苯和联苯-4,4'-二甲醛在内的芳烃和芳醛的水溶性,其中4,4'-二甲基联苯的溶解度可以提高到8.9 mmol/L,联苯-4,4'-二甲醛的溶解度可以提高到11.2 mmol/L.并入四个羧酸根的acCB-2<\/b>可以把五氟甲苯和六氟苯在水中的溶解度提高到5.6和3.0 mmol/L.acCB-1<\/b>还可以通过增溶芳香醛,促进其与酰肼反应形成腙.这一促进作用可以进一步应用于促进两个芳香二醛和一个芳香二酰肼在水中的反应,制备常规条件下不能形成的两个芳香腙大环.","abstractInfoEn":"The promotion of two sulfate or carboxylate-bearing acyclic cucurbiturils for the water-solubility of arenes and aromatic aldehydes is described. 1<\/sup>H NMR experiments reveals that sulfate-bearing acyclic cucurbituril (acCB-1<\/b>) signficantly improves the water-solubility of a number of arenes and aldehydes. For 4, 4'-dimethylbiphenyl and biphenyl-4, 4'-dicarbaldehyde, the solubility can be improved to 8.9 and 11.2 mmol/L, respectively. 19<\/sup>F NMR experiments demonstrate that carboxylate-bearing acyclic cucurbituril can increase the water-solubilities of pentafluorotoluene and hexafluorobenzene to 5.6 and 3.0 mmol/L, respectively. It is also found that the water-solubilization of acCB-1<\/b> for aromatic aldehydes can promote their reaction with acylhydrazines to form hydrozone derivatives. By making use of this promotion, two hydrazone-based macrocycles can be formed from the coupling reactions of two aromatic dialdehdes and one diacylhydrazine in water.","articleNo":"","authorCnList":["刘旭波"," 林佳乐"," 王辉"," 张丹维"," 黎占亭"],"authorEnList":["Liu Xu-Bo"," Lin Jia-Le"," Wang Hui"," Zhang Dan-Wei"," Li Zhan-Ting"],"authorList":["刘旭波"," 林佳乐"," 王辉"," 张丹维"," 黎占亭"],"authors":"刘旭波, 林佳乐, 王辉, 张丹维, 黎占亭","authorsCn":"刘旭波, 林佳乐, 王辉, 张丹维, 黎占亭","authorsEn":"Liu Xu-Bo, Lin Jia-Le, Wang Hui, Zhang Dan-Wei, Li Zhan-Ting","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"刘旭波, 林佳乐, 王辉, 张丹维, 黎占亭. 开环葫芦脲在水中对芳烃和芳醛的增溶和对腙大环形成的促进作用. 有机化学, 2020, 40(3): 663-668. doi: 10.6023/cjoc201910022.","citationCn":"刘旭波, 林佳乐, 王辉, 张丹维, 黎占亭. 开环葫芦脲在水中对芳烃和芳醛的增溶和对腙大环形成的促进作用. 有机化学, 2020, 40(3): 663-668. doi: 10.6023/cjoc201910022.","citationEn":"刘旭波, 林佳乐, 王辉, 张丹维, 黎占亭. Water-Solubilization of Acyclic Cucurbiturils for Arenes and Aromatic Aldehydes and the Promotion for the Generation of Two Hydrazine-Based Macrocycles. Chinese Journal of Organic Chemistry, 2020, 40(3): 663-668. doi: 10.6023/cjoc201910022.","doi":"10.6023/cjoc201910022","figContent":"yjhx-40-3-663-1.jpg$$yjhx-40-3-663-2.jpg$$yjhx-40-3-663-3.jpg$$yjhx-40-3-663-4.jpg","figList":["yjhx-40-3-663-1.jpg","yjhx-40-3-663-2.jpg","yjhx-40-3-663-3.jpg","yjhx-40-3-663-4.jpg"],"firstFig":"yjhx-40-3-663-1.jpg","fpage":"663","highCitedState":"","htmlCount":48,"htmlFile":"","id":"44d7c87f-2690-491a-b02f-14f13802beb9","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"开环葫芦脲, 水相增溶, 包结, 芳烃, 芳醛, 腙, 大环化合物","keywordCn":"开环葫芦脲, 水相增溶, 包结, 芳烃, 芳醛, 腙, 大环化合物","keywordCnList":["开环葫芦脲"," 水相增溶"," 包结"," 芳烃"," 芳醛"," 腙"," 大环化合物"],"keywordEn":"acyclic cucurbituril, water-solubilization, encapsulation, arene, aromatic aldehyde, hydrazine, macrocycle","keywordEnList":["acyclic cucurbituril"," water-solubilization"," encapsulation"," arene"," aromatic aldehyde"," hydrazine"," macrocycle"],"keywordList":["开环葫芦脲"," 水相增溶"," 包结"," 芳烃"," 芳醛"," 腙"," 大环化合物"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"668","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":6,"pdfSize":1758.15,"pubDate":"2020-03-25","recommendState":"","releaseState":"1","secCount":0,"title":"开环葫芦脲在水中对芳烃和芳醛的增溶和对腙大环形成的促进作用","titleCn":"开环葫芦脲在水中对芳烃和芳醛的增溶和对腙大环形成的促进作用","titleEn":"Water-Solubilization of Acyclic Cucurbiturils for Arenes and Aromatic Aldehydes and the Promotion for the Generation of Two Hydrazine-Based Macrocycles","viewCount":255,"volume":"40","year":2020},{"abstractInfo":"从胡椒酸出发,通过还原、甲磺酸酯化、偶联和成盐四步反应合成了一系列新型的胡椒基咪唑盐类化合物,其结构经1<\/sup>HNMR,13<\/sup>CNMR,HRMS以及X射线单晶衍射确定.对合成的新化合物进行了体外抗肿瘤细胞毒活性筛选,结果表明,1-((苯并[d<\/i>][1,3]二氧杂环戊烯-5-基甲基)-3-(2-萘甲基))-5,6-二甲基-1H<\/i>-苯并[d<\/i>]咪唑-3-溴盐(30<\/b>)具有显著的细胞毒活性,对HL-60、SMMC-7721、A-549、MCF-7和SW-480肿瘤细胞株的活性均优于顺铂(DDP),尤其对HL-60肿瘤细胞株表现出较好的选择性细胞毒活性,其IC50<\/sub>值约为顺铂的7.2倍.进一步研究表明,化合物30<\/b>具有诱导SMMC-7721细胞株在细胞周期G0/G1期阻滞和细胞凋亡的作用.","abstractInfoCn":"从胡椒酸出发,通过还原、甲磺酸酯化、偶联和成盐四步反应合成了一系列新型的胡椒基咪唑盐类化合物,其结构经1<\/sup>H NMR,13<\/sup>C NMR,HRMS以及X射线单晶衍射确定.对合成的新化合物进行了体外抗肿瘤细胞毒活性筛选,结果表明,1-((苯并[d<\/i>][1, 3]二氧杂环戊烯-5-基甲基)-3-(2-萘甲基))-5,6-二甲基-1H<\/i>-苯并[d<\/i>]咪唑-3-溴盐(30<\/b>)具有显著的细胞毒活性,对HL-60、SMMC-7721、A-549、MCF-7和SW-480肿瘤细胞株的活性均优于顺铂(DDP),尤其对HL-60肿瘤细胞株表现出较好的选择性细胞毒活性,其IC50<\/sub>值约为顺铂的7.2倍.进一步研究表明,化合物30<\/b>具有诱导SMMC-7721细胞株在细胞周期G0/G1期阻滞和细胞凋亡的作用.","abstractInfoEn":"A series of novel hybrid compounds between piperonyl and imidazolium salts were prepared from tryptophol by four steps of reduction, mesylation, coupling and salt formation. Their structures were confirmed by 1<\/sup>H NMR, 13<\/sup>C NMR, HRMS and X-ray crystallographic analysis. These compounds were evaluated in vitro<\/i> against a panel of human tumor cell lines. The results showed that 1-((benzo[d<\/i>] [1, 3]dioxol-5-ylmethyl)-3-(2-naphthylmethyl))-5, 6-dimethyl-1H<\/i>-benzo[d<\/i>]imidazol-3-ium bromide (30<\/b>) exhibited remarkable inhibitory activity selectively against HL-60, SMMC-7721, A-549, MCF-7 and SW480 cell lines compared with DDP. In particular, the compound was more selective to HL-60 cell lines with IC50<\/sub> values 7.2-fold lower than DDP. Further studies showed that compound 30<\/b> has the effect of inducing SMMC-7721 cell line arrest and cell apoptosis in cell cycle G0/G1.","articleNo":"","authorCnList":["刘正芬"," 字玉金"," 张琳琳"," 方永晟"," 沈艳珍"," 李艳"," 羊晓东"," 张洪彬"],"authorEnList":["Liu Zhengfen"," Zi Yujin"," Zhang Linlin"," Fang Yongsheng"," Shen Yanzhen"," Li Yan"," Yang Xiaodong"," Zhang Hongbin"],"authorList":["刘正芬"," 字玉金"," 张琳琳"," 方永晟"," 沈艳珍"," 李艳"," 羊晓东"," 张洪彬"],"authors":"刘正芬, 字玉金, 张琳琳, 方永晟, 沈艳珍, 李艳, 羊晓东, 张洪彬","authorsCn":"刘正芬, 字玉金, 张琳琳, 方永晟, 沈艳珍, 李艳, 羊晓东, 张洪彬","authorsEn":"Liu Zhengfen, Zi Yujin, Zhang Linlin, Fang Yongsheng, Shen Yanzhen, Li Yan, Yang Xiaodong, Zhang Hongbin","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"刘正芬, 字玉金, 张琳琳, 方永晟, 沈艳珍, 李艳, 羊晓东, 张洪彬. 胡椒基咪唑盐类化合物的合成及生物活性研究. 有机化学, 2020, 40(3): 669-678. doi: 10.6023/cjoc201909042.","citationCn":"刘正芬, 字玉金, 张琳琳, 方永晟, 沈艳珍, 李艳, 羊晓东, 张洪彬. 胡椒基咪唑盐类化合物的合成及生物活性研究. 有机化学, 2020, 40(3): 669-678. doi: 10.6023/cjoc201909042.","citationEn":"刘正芬, 字玉金, 张琳琳, 方永晟, 沈艳珍, 李艳, 羊晓东, 张洪彬. Synthesis and Cytotoxic Activity of Novel Hybrid Compounds between Piperonyl and Imidazolium Salts. Chinese Journal of Organic Chemistry, 2020, 40(3): 669-678. doi: 10.6023/cjoc201909042.","doi":"10.6023/cjoc201909042","figContent":"yjhx-40-3-669-1.jpg$$yjhx-40-3-669-S1.jpg$$yjhx-40-3-669-2.jpg$$yjhx-40-3-669-3.jpg$$yjhx-40-3-669-4.jpg$$yjhx-40-3-669-5.jpg$$yjhx-40-3-669-6.jpg","figList":["yjhx-40-3-669-1.jpg","yjhx-40-3-669-S1.jpg","yjhx-40-3-669-2.jpg","yjhx-40-3-669-3.jpg","yjhx-40-3-669-4.jpg","yjhx-40-3-669-5.jpg","yjhx-40-3-669-6.jpg"],"firstFig":"yjhx-40-3-669-1.jpg","fpage":"669","highCitedState":"","htmlCount":67,"htmlFile":"","id":"8657e149-ee0e-4700-869b-3334573d6d4d","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"胡椒基, 咪唑盐, 分子杂合, 构效关系, 细胞毒活性","keywordCn":"胡椒基, 咪唑盐, 分子杂合, 构效关系, 细胞毒活性","keywordCnList":["胡椒基"," 咪唑盐"," 分子杂合"," 构效关系"," 细胞毒活性"],"keywordEn":"piperonyl, imidazolium salts, molecular hybridization, structure-activity relationship, cytotoxic activity","keywordEnList":["piperonyl"," imidazolium salts"," molecular hybridization"," structure-activity relationship"," cytotoxic activity"],"keywordList":["胡椒基"," 咪唑盐"," 分子杂合"," 构效关系"," 细胞毒活性"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"678","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":3,"pdfSize":1826.5,"pubDate":"2020-03-25","recommendState":"","releaseState":"1","secCount":0,"title":"胡椒基咪唑盐类化合物的合成及生物活性研究","titleCn":"胡椒基咪唑盐类化合物的合成及生物活性研究","titleEn":"Synthesis and Cytotoxic Activity of Novel Hybrid Compounds between Piperonyl and Imidazolium Salts","viewCount":432,"volume":"40","year":2020},{"abstractInfo":"应用多种色谱和波谱学方法,从云南蕊木(Kopsiaofficinalis<\/i>)茎中分离鉴定了27个单萜吲哚生物碱,包括7个新化合物kopsiofficinesA~G和20个已知化合物.此外,建立脂多糖(LPS)诱导的小鼠巨噬细胞RAW264.7炎症模型,通过测定IL-1β,PGE2和TNF-α炎症因子释放评价生物碱的抗炎活性.结果表明,kopsiofficinesA(1<\/b>),kopsiofficinesB(2<\/b>),kopsiofficinesD(4<\/b>),kopsiofficinesF(6<\/b>),kopsiofficinesG(7<\/b>),12-methoxykopsine(11<\/b>),kopsinoline(15<\/b>),(-)-N<\/i>-methoxy-carbonyl-11,12-methylenedioxykopsinaline(16<\/b>),kopsinine(18<\/b>)和kopsinicacid(20<\/b>)表现出显著的抗炎活性,与阳性对照(地塞米松)基本相当.研究发现C-5位丙酮基取代的单萜吲哚生物碱的抗炎活性明显强于原型生物碱,推测丙酮基可能是抗炎活性的药效促进基团,研究结果为进一步的结构修饰和药理学研究提供了线索.","abstractInfoCn":"应用多种色谱和波谱学方法,从云南蕊木(Kopsia officinalis<\/i>)茎中分离鉴定了27个单萜吲哚生物碱,包括7个新化合物kopsiofficines A~G和20个已知化合物.此外,建立脂多糖(LPS)诱导的小鼠巨噬细胞RAW 264.7炎症模型,通过测定IL-1β,PGE2和TNF-α炎症因子释放评价生物碱的抗炎活性.结果表明,kopsiofficines A(1<\/b>),kopsiofficines B(2<\/b>),kopsiofficines D(4<\/b>),kopsiofficines F(6<\/b>),kopsiofficines G(7<\/b>),12-methoxykopsine(11<\/b>),kopsinoline(15<\/b>),(-)-N<\/i>-methoxy-carbonyl-11,12-methylenedioxykopsinaline(16<\/b>),kopsinine(18<\/b>)和kopsinic acid(20<\/b>)表现出显著的抗炎活性,与阳性对照(地塞米松)基本相当.研究发现C-5位丙酮基取代的单萜吲哚生物碱的抗炎活性明显强于原型生物碱,推测丙酮基可能是抗炎活性的药效促进基团,研究结果为进一步的结构修饰和药理学研究提供了线索.","abstractInfoEn":"Seven new monoterpenoid indole alkaloids, kopsiofficines A~G, together with twenty known alkaloids, were isolated from the stems of Kopsia officinalis<\/i>. Their structures were elucidated on the basis of extensive spectroscopic methods. The anti-inflammatory activities of all alkaloids were evaluated on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells by the inhibiting the production of IL-1β, PGE2 and TNF-α. Among them, kopsiofficines A (1<\/b>), kopsiofficines B (2<\/b>), kopsiofficines D (4<\/b>), kopsiofficines F (6<\/b>), kopsiofficines G (7<\/b>), 12-methoxykopsine (11<\/b>), kopsinoline (15<\/b>), (-)-N<\/i>-methoxycarbonyl-11, 12-methylenedioxykopsinaline (16<\/b>), kopsinine (18<\/b>) and kopsinic acid (20<\/b>) exhibited significant anti-inflammatory activity, which were comparable to that of dexamethasone. The results supposed that the acetonyl group at C-5 of monoterpenoid indole alkaloids play an important role in their anti-inflammatory activity.","articleNo":"","authorCnList":["解天珍"," 赵云丽"," 马伟光"," 王易芬"," 于浩飞"," 王蓓"," 魏鑫"," 黄之镨"," 朱培凤"," 刘亚平"," 罗晓东"],"authorEnList":["Xie Tian-Zhen"," Zhao Yun-Li"," Ma Wei-Guang"," Wang Yi-Fen"," Yu Hao-Fei"," Wang Bei"," Wei Xin"," Huang Zhi-Pu"," Zhu Pei-Feng"," Liu Ya-Ping"," Luo Xiao-Dong"],"authorList":["解天珍"," 赵云丽"," 马伟光"," 王易芬"," 于浩飞"," 王蓓"," 魏鑫"," 黄之镨"," 朱培凤"," 刘亚平"," 罗晓东"],"authors":"解天珍, 赵云丽, 马伟光, 王易芬, 于浩飞, 王蓓, 魏鑫, 黄之镨, 朱培凤, 刘亚平, 罗晓东","authorsCn":"解天珍, 赵云丽, 马伟光, 王易芬, 于浩飞, 王蓓, 魏鑫, 黄之镨, 朱培凤, 刘亚平, 罗晓东","authorsEn":"Xie Tian-Zhen, Zhao Yun-Li, Ma Wei-Guang, Wang Yi-Fen, Yu Hao-Fei, Wang Bei, Wei Xin, Huang Zhi-Pu, Zhu Pei-Feng, Liu Ya-Ping, Luo Xiao-Dong","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"解天珍, 赵云丽, 马伟光, 王易芬, 于浩飞, 王蓓, 魏鑫, 黄之镨, 朱培凤, 刘亚平, 罗晓东. 云南蕊木茎中的抗炎吲哚生物碱. 有机化学, 2020, 40(3): 679-687. doi: 10.6023/cjoc201909036.","citationCn":"解天珍, 赵云丽, 马伟光, 王易芬, 于浩飞, 王蓓, 魏鑫, 黄之镨, 朱培凤, 刘亚平, 罗晓东. 云南蕊木茎中的抗炎吲哚生物碱. 有机化学, 2020, 40(3): 679-687. doi: 10.6023/cjoc201909036.","citationEn":"解天珍, 赵云丽, 马伟光, 王易芬, 于浩飞, 王蓓, 魏鑫, 黄之镨, 朱培凤, 刘亚平, 罗晓东. Anti-Inflammatory Indole Alkaloids from the Stems of Kopsia officinalis<\/i>. Chinese Journal of Organic Chemistry, 2020, 40(3): 679-687. doi: 10.6023/cjoc201909036.","doi":"10.6023/cjoc201909036","figContent":"yjhx-40-3-679-1.jpg$$yjhx-40-3-679-2.jpg$$yjhx-40-3-679-3.jpg$$yjhx-40-3-679-4.jpg","figList":["yjhx-40-3-679-1.jpg","yjhx-40-3-679-2.jpg","yjhx-40-3-679-3.jpg","yjhx-40-3-679-4.jpg"],"firstFig":"yjhx-40-3-679-1.jpg","fpage":"679","highCitedState":"","htmlCount":67,"htmlFile":"","id":"ee97fd57-7447-4c14-a6c4-b2281fd9261a","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"云南蕊木, kopsiofficines A~G, 抗炎, 单萜吲哚生物碱","keywordCn":"云南蕊木, kopsiofficines A~G, 抗炎, 单萜吲哚生物碱","keywordCnList":["云南蕊木"," kopsiofficines A~G"," 抗炎"," 单萜吲哚生物碱"],"keywordEn":"Kopsia officinalis<\/i>, kopsiofficines A~G, anti-inflammatory, monoterpenoid indole alkaloids","keywordEnList":["Kopsia officinalis<\/i>"," kopsiofficines A~G"," anti-inflammatory"," monoterpenoid indole alkaloids"],"keywordList":["云南蕊木"," kopsiofficines A~G"," 抗炎"," 单萜吲哚生物碱"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"687","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":4,"pdfSize":871.8,"pubDate":"2020-03-25","recommendState":"","releaseState":"1","secCount":0,"title":"云南蕊木茎中的抗炎吲哚生物碱","titleCn":"云南蕊木茎中的抗炎吲哚生物碱","titleEn":"Anti-Inflammatory Indole Alkaloids from the Stems of Kopsia officinalis<\/i>","viewCount":316,"volume":"40","year":2020},{"abstractInfo":"报道了一种新型的Zn/Y双金属接力催化的串联反应,该方法通过Zn(OTf)2<\/sub>和Y(OTf)3<\/sub>接力催化,一锅法进行分子内环异构化/分子间阿尔德-烯反应构建α<\/i>-羟基酰胺噁唑衍生物.产物的形成主要是由Zn(OTf)2<\/sub>活化炔丙基酰胺的叁键发生分子内的环化反应构建噁唑啉中间体,由Y(OTf)3<\/sub>催化1-苄基吲哚啉-2,3-二酮类化合物,继而由噁唑啉中间体与1-苄基吲哚啉-2,3-二酮类化合物发生分子间阿尔德-烯反应,实现了α<\/i>-羟基酰胺噁唑衍生物的合成.优化部分的对比实验证实,Zn(OTf)2<\/sub>和Y(OTf)3<\/sub>的存在对于该串联反应都是必须条件.所有反应都是将各反应物和试剂一次性加入,在空气氛围下100℃加热进行反应.该方法反应条件简单、原子经济性高、官能团兼容性好,对噁唑衍生物合成具有重要的意义.","abstractInfoCn":"报道了一种新型的Zn/Y双金属接力催化的串联反应,该方法通过Zn(OTf)2<\/sub>和Y(OTf)3<\/sub>接力催化,一锅法进行分子内环异构化/分子间阿尔德-烯反应构建α<\/i>-羟基酰胺噁唑衍生物.产物的形成主要是由Zn(OTf)2<\/sub>活化炔丙基酰胺的叁键发生分子内的环化反应构建噁唑啉中间体,由Y(OTf)3<\/sub>催化1-苄基吲哚啉-2,3-二酮类化合物,继而由噁唑啉中间体与1-苄基吲哚啉-2,3-二酮类化合物发生分子间阿尔德-烯反应,实现了α<\/i>-羟基酰胺噁唑衍生物的合成.优化部分的对比实验证实,Zn(OTf)2<\/sub>和Y(OTf)3<\/sub>的存在对于该串联反应都是必须条件.所有反应都是将各反应物和试剂一次性加入,在空气氛围下100℃加热进行反应.该方法反应条件简单、原子经济性高、官能团兼容性好,对噁唑衍生物合成具有重要的意义.","abstractInfoEn":"A novel tandem metal relay catalytic system of Zn/Y has been successfully developed. By using this unprecedented Zn(OTf)2<\/sub>/Y(OTf)3<\/sub> bimetallic relay catalytic system, a variety of oxazole α<\/i>-hydroxy amides derivatives were obtained from easily available N<\/i>-(propargyl)-arylamides and various 1-benzylindoline-2, 3-dione derivatives through intramolecular cycloisomerization/intermolecular Alder-ene reaction under mild conditions. The first step of the one-pot procedure is that Zn(OTf)2<\/sub> acts as a π acid to activate the triple bond of N<\/i>-(propargyl)-arylamides, and a subsequent intramolecular 5-exo-dig cyclization forms the oxazoline intermediate. Separately, Y(OTf)3<\/sub> acts as Lewis acid, then oxazoline intermediate and 1-benzylindoline-2, 3-dione derivatives are transformed to the oxazole α<\/i>-hydroxy amide derivatives in good to excellent yields in an intermolecular Alder-ene reaction. Control experiments in the optimization section disclose the fact that Zn(OTf)2<\/sub> and Y(OTf)3<\/sub> are both indispensable for this intramolecular cycloisomerization/intermolecular Alder-ene reaction. Generally, the synthetic reactions run under air atmosphere by heating all the substrates and reagents in one-pot at 100℃. The present method benefits from the distinctive features of simple reaction conditions, high atom economy and broad substrate tolerance. It is of great significance for the synthesis of oxazole derivatives.","articleNo":"","authorCnList":["张硕"," 楼建芳"," 王佳睿"," 宋子贺"," 彭丹"," 王峰"," 闫志旺"," 崔仕麒"," 刘一帆"," 牟秋红"," 李金辉"],"authorEnList":["Zhang Shuo"," Lou Jianfang"," Wang Jiarui"," Song Zihe"," Peng Dan"," Wang Feng"," Yan Zhiwang"," Cui Shiqi"," Liu Yifan"," Mu Qiuhong"," Li Jinhui"],"authorList":["张硕"," 楼建芳"," 王佳睿"," 宋子贺"," 彭丹"," 王峰"," 闫志旺"," 崔仕麒"," 刘一帆"," 牟秋红"," 李金辉"],"authors":"张硕, 楼建芳, 王佳睿, 宋子贺, 彭丹, 王峰, 闫志旺, 崔仕麒, 刘一帆, 牟秋红, 李金辉","authorsCn":"张硕, 楼建芳, 王佳睿, 宋子贺, 彭丹, 王峰, 闫志旺, 崔仕麒, 刘一帆, 牟秋红, 李金辉","authorsEn":"Zhang Shuo, Lou Jianfang, Wang Jiarui, Song Zihe, Peng Dan, Wang Feng, Yan Zhiwang, Cui Shiqi, Liu Yifan, Mu Qiuhong, Li Jinhui","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"张硕, 楼建芳, 王佳睿, 宋子贺, 彭丹, 王峰, 闫志旺, 崔仕麒, 刘一帆, 牟秋红, 李金辉. Zn/Y双金属接力催化:一锅法分子内环异构化/分子间阿尔德-烯反应构建α<\/i>-羟基酰胺噁唑衍生物. 有机化学, 2020, 40(3): 704-713. doi: 10.6023/cjoc201909002.","citationCn":"张硕, 楼建芳, 王佳睿, 宋子贺, 彭丹, 王峰, 闫志旺, 崔仕麒, 刘一帆, 牟秋红, 李金辉. Zn/Y双金属接力催化:一锅法分子内环异构化/分子间阿尔德-烯反应构建α<\/i>-羟基酰胺噁唑衍生物. 有机化学, 2020, 40(3): 704-713. doi: 10.6023/cjoc201909002.","citationEn":"张硕, 楼建芳, 王佳睿, 宋子贺, 彭丹, 王峰, 闫志旺, 崔仕麒, 刘一帆, 牟秋红, 李金辉. Zn/Y Bimetallic Relay Catalysis: One Pot Intramolecular Cyclo-isomerization/Intermolecular Alder-Ene Reaction toward Oxazole α<\/i>-Hydroxy Amide Derivatives. Chinese Journal of Organic Chemistry, 2020, 40(3): 704-713. doi: 10.6023/cjoc201909002.","doi":"10.6023/cjoc201909002","figContent":"yjhx-40-3-704-S2.jpg","figList":["yjhx-40-3-704-S2.jpg"],"firstFig":"yjhx-40-3-704-S2.jpg","fpage":"704","highCitedState":"","htmlCount":45,"htmlFile":"","id":"5fb99f74-38b2-4205-9c81-65387181e0fc","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"接力催化, 环异构化, 阿尔德-烯反应, 噁唑衍生物","keywordCn":"接力催化, 环异构化, 阿尔德-烯反应, 噁唑衍生物","keywordCnList":["接力催化"," 环异构化"," 阿尔德-烯反应"," 噁唑衍生物"],"keywordEn":"relay catalysis, cycloisomerization, Alder-Ene reaction, oxazole derivatives","keywordEnList":["relay catalysis"," cycloisomerization"," Alder-Ene reaction"," oxazole derivatives"],"keywordList":["接力催化"," 环异构化"," 阿尔德-烯反应"," 噁唑衍生物"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"713","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":3,"pdfSize":574.89,"pubDate":"2020-03-01","recommendState":"","releaseState":"1","secCount":0,"title":"Zn/Y双金属接力催化:一锅法分子内环异构化/分子间阿尔德-烯反应构建α<\/i>-羟基酰胺噁唑衍生物","titleCn":"Zn/Y双金属接力催化:一锅法分子内环异构化/分子间阿尔德-烯反应构建α<\/i>-羟基酰胺噁唑衍生物","titleEn":"Zn/Y Bimetallic Relay Catalysis: One Pot Intramolecular Cyclo-isomerization/Intermolecular Alder-Ene Reaction toward Oxazole α<\/i>-Hydroxy Amide Derivatives","viewCount":340,"volume":"40","year":2020},{"abstractInfo":"报道了利用廉价易得的二甲基亚砜作为甲硫基源,实现8-氨基喹啉导向的芳基酰胺的二甲硫基化反应.利用CuSO4<\/sub>·5H2<\/sub>O作为促进剂,以中等到较好的收率高效地合成了一系列含有二甲硫基的芳酰胺衍生物.此外,该反应体系具有反应条件温和、不需要外加其它氧化剂的特点.","abstractInfoCn":"报道了利用廉价易得的二甲基亚砜作为甲硫基源,实现8-氨基喹啉导向的芳基酰胺的二甲硫基化反应.利用CuSO4<\/sub>·5H2<\/sub>O作为促进剂,以中等到较好的收率高效地合成了一系列含有二甲硫基的芳酰胺衍生物.此外,该反应体系具有反应条件温和、不需要外加其它氧化剂的特点.","abstractInfoEn":"Cu(Ⅱ)-promoted dimethylthiolation of C(sp2<\/sup>)-H bonds using DMSO as the methylthiolation source with the assistance of an 8-aminoquinoline directing group have been developed. A number of dimethylthiolated benzamides were efficiently synthesized using CuSO4<\/sub>·5H2<\/sub>O as a promoter in moderate to good yields. In addition, this reaction system features facile conditions and no other oxidant additive was required.","articleNo":"","authorCnList":["郭圆圆"," 刘振伟"," 朱明祥"," 李琳琳"," 李敬亚"," 邹大鹏"," 吴豫生"," 吴养洁"],"authorEnList":["Guo Yuanyuan"," Liu Zhenwei"," Zhu Mingxiang"," Li Linlin"," Li Jingya"," Zou Dapeng"," Wu Yusheng"," Wu Yangjie"],"authorList":["郭圆圆"," 刘振伟"," 朱明祥"," 李琳琳"," 李敬亚"," 邹大鹏"," 吴豫生"," 吴养洁"],"authors":"郭圆圆, 刘振伟, 朱明祥, 李琳琳, 李敬亚, 邹大鹏, 吴豫生, 吴养洁","authorsCn":"郭圆圆, 刘振伟, 朱明祥, 李琳琳, 李敬亚, 邹大鹏, 吴豫生, 吴养洁","authorsEn":"Guo Yuanyuan, Liu Zhenwei, Zhu Mingxiang, Li Linlin, Li Jingya, Zou Dapeng, Wu Yusheng, Wu Yangjie","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"郭圆圆, 刘振伟, 朱明祥, 李琳琳, 李敬亚, 邹大鹏, 吴豫生, 吴养洁. 铜促进8-氨基喹啉导向的芳基酰胺的二甲硫基化反应. 有机化学, 2020, 40(3): 724-730. doi: 10.6023/cjoc201908036.","citationCn":"郭圆圆, 刘振伟, 朱明祥, 李琳琳, 李敬亚, 邹大鹏, 吴豫生, 吴养洁. 铜促进8-氨基喹啉导向的芳基酰胺的二甲硫基化反应. 有机化学, 2020, 40(3): 724-730. doi: 10.6023/cjoc201908036.","citationEn":"郭圆圆, 刘振伟, 朱明祥, 李琳琳, 李敬亚, 邹大鹏, 吴豫生, 吴养洁. Copper-Promoted Dimethylthiolation of Benzamides under Assistance of 8-Aminoquinoline Group. Chinese Journal of Organic Chemistry, 2020, 40(3): 724-730. doi: 10.6023/cjoc201908036.","doi":"10.6023/cjoc201908036","figContent":"yjhx-40-3-724-S1.jpg$$yjhx-40-3-724-S2.jpg","figList":["yjhx-40-3-724-S1.jpg","yjhx-40-3-724-S2.jpg"],"firstFig":"yjhx-40-3-724-S1.jpg","fpage":"724","highCitedState":"","htmlCount":34,"htmlFile":"","id":"3b1e97f6-fbea-4360-bc44-5ebeb80b32a9","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"二甲硫基化, 二甲基亚砜, 8-氨基喹啉, Cu促进","keywordCn":"二甲硫基化, 二甲基亚砜, 8-氨基喹啉, Cu促进","keywordCnList":["二甲硫基化"," 二甲基亚砜"," 8-氨基喹啉"," Cu促进"],"keywordEn":"Dimethylthiolation, DMSO, 8-Aminoquinoline, Copper-promoted","keywordEnList":["Dimethylthiolation"," DMSO"," 8-Aminoquinoline"," Copper-promoted"],"keywordList":["二甲硫基化"," 二甲基亚砜"," 8-氨基喹啉"," Cu促进"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"730","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":4,"pdfSize":498.59,"pubDate":"2020-03-01","recommendState":"","releaseState":"1","secCount":0,"title":"铜促进8-氨基喹啉导向的芳基酰胺的二甲硫基化反应","titleCn":"铜促进8-氨基喹啉导向的芳基酰胺的二甲硫基化反应","titleEn":"Copper-Promoted Dimethylthiolation of Benzamides under Assistance of 8-Aminoquinoline Group","viewCount":243,"volume":"40","year":2020},{"abstractInfo":"为了寻求新型抗肿瘤药物,设计并合成了一系列新型1,3,4-噁二唑和1,3,4-噻二唑衍生物,对这些化合物在人类四种癌细胞:B-16(皮肤黑色素瘤细胞)、PC-3(人前列腺癌细胞)、U87(人原发性胶质母细胞瘤细胞)和A549(人非小细胞肺癌细胞)进行抗肿瘤活性评价.结果显示部分化合物具有较好的抗肿瘤活性,尤其是5-{6-[4-(2-羟基乙基)哌嗪-1-基]-2-甲基嘧啶-4-基氨基}-[1,3,4-噻二唑-2-羧酸(2-甲氧基苯基)酰胺(8b<\/b>)和5-{6-[4-(2-羟基乙基)哌嗪-1-基]-2-甲基嘧啶-4-基氨基}-[1,3,4-噻二唑-2-羧酸(4-甲氧基苯基)酰胺(8c<\/b>),对四种癌细胞都显示出较高的抗肿瘤活性,其抑制活性均优于阳性对照达沙替尼.随后对这类化合物抑制肿瘤的可能靶点开展了进一步研究.","abstractInfoCn":"为了寻求新型抗肿瘤药物,设计并合成了一系列新型1,3,4-噁二唑和1,3,4-噻二唑衍生物,对这些化合物在人类四种癌细胞:B-16(皮肤黑色素瘤细胞)、PC-3(人前列腺癌细胞)、U87(人原发性胶质母细胞瘤细胞)和A549(人非小细胞肺癌细胞)进行抗肿瘤活性评价.结果显示部分化合物具有较好的抗肿瘤活性,尤其是5-{6-[4-(2-羟基乙基)哌嗪-1-基]-2-甲基嘧啶-4-基氨基}-[1,3,4-噻二唑-2-羧酸(2-甲氧基苯基)酰胺(8b<\/b>)和5-{6-[4-(2-羟基乙基)哌嗪-1-基]-2-甲基嘧啶-4-基氨基}-[1,3,4-噻二唑-2-羧酸(4-甲氧基苯基)酰胺(8c<\/b>),对四种癌细胞都显示出较高的抗肿瘤活性,其抑制活性均优于阳性对照达沙替尼.随后对这类化合物抑制肿瘤的可能靶点开展了进一步研究.","abstractInfoEn":"In order to find new anti-tumor drugs, a series of novel 1, 3, 4-oxadiazole and 1, 3, 4-thiadiazole derivatives were designed and synthesized. The target compounds were evaluated for antitumor activity in vitro<\/i> on four human cancer cell lines including B-16 (skin melanoma cells), PC-3 (human prostate cancer cells), U87 (human primary glioblastoma cells) and A549 (human non-small cell lung cancer cells). The results displayed that some of the compounds had good activities, especially, 5-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-N<\/i>-(2-methoxyphenyl)-1, 3, 4-thiadiazole-2-carboxamide (8b<\/b>) and 5-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-N<\/i>-(4-methoxyphenyl)-1, 3, 4-thiadiazole-2-carboxamide (8c<\/b>) showed high antitumor activities against four cancer cell lines, which was better than dasatinib. These compounds were further studied for their possible target of tumor suppression.","articleNo":"","authorCnList":["鄢龙家"," 黎永良"," 邓明高"," 陈安超"," 杜志云"," 董长治"," 陈惠雄"],"authorEnList":["Yan Longjia"," Li Yongliang"," Deng Minggao"," Chen Anchao"," Du Zhiyun"," Dong Changzhi"," Chen Huixiong"],"authorList":["鄢龙家"," 黎永良"," 邓明高"," 陈安超"," 杜志云"," 董长治"," 陈惠雄"],"authors":"鄢龙家, 黎永良, 邓明高, 陈安超, 杜志云, 董长治, 陈惠雄","authorsCn":"鄢龙家, 黎永良, 邓明高, 陈安超, 杜志云, 董长治, 陈惠雄","authorsEn":"Yan Longjia, Li Yongliang, Deng Minggao, Chen Anchao, Du Zhiyun, Dong Changzhi, Chen Huixiong","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"鄢龙家, 黎永良, 邓明高, 陈安超, 杜志云, 董长治, 陈惠雄. 1, 3, 4-噁二唑和1, 3, 4-噻二唑衍生物的设计、合成和生物活性研究. 有机化学, 2020, 40(3): 731-739. doi: 10.6023/cjoc201907052.","citationCn":"鄢龙家, 黎永良, 邓明高, 陈安超, 杜志云, 董长治, 陈惠雄. 1, 3, 4-噁二唑和1, 3, 4-噻二唑衍生物的设计、合成和生物活性研究. 有机化学, 2020, 40(3): 731-739. doi: 10.6023/cjoc201907052.","citationEn":"鄢龙家, 黎永良, 邓明高, 陈安超, 杜志云, 董长治, 陈惠雄. Design, Synthesis and Biological Activities of Compounds Containing 1, 3, 4-Oxadiazole or 1, 3, 4-Thiadiazole. Chinese Journal of Organic Chemistry, 2020, 40(3): 731-739. doi: 10.6023/cjoc201907052.","doi":"10.6023/cjoc201907052","figContent":"yjhx-40-3-731-1.jpg$$yjhx-40-3-731-S1.jpg$$yjhx-40-3-731-S2.jpg$$yjhx-40-3-731-2.jpg","figList":["yjhx-40-3-731-1.jpg","yjhx-40-3-731-S1.jpg","yjhx-40-3-731-S2.jpg","yjhx-40-3-731-2.jpg"],"firstFig":"yjhx-40-3-731-1.jpg","fpage":"731","highCitedState":"","htmlCount":9,"htmlFile":"","id":"9cbeafa5-8ade-45b8-83e7-093df8f76e0c","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"1, 3, 4-噁二唑, 1, 3, 4-噻二唑, 抗肿瘤, Src抑制剂","keywordCn":"1, 3, 4-噁二唑, 1, 3, 4-噻二唑, 抗肿瘤, Src抑制剂","keywordCnList":["1"," 3"," 4-噁二唑"," 1"," 3"," 4-噻二唑"," 抗肿瘤"," Src抑制剂"],"keywordEn":"1, 3, 4-oxadiazole, 1, 3, 4-thiadiazole, anti-cancer, Src inhibitor","keywordEnList":["1"," 3"," 4-oxadiazole"," 1"," 3"," 4-thiadiazole"," anti-cancer"," Src inhibitor"],"keywordList":["1"," 3"," 4-噁二唑"," 1"," 3"," 4-噻二唑"," 抗肿瘤"," Src抑制剂"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"739","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":6,"pdfSize":1206.65,"pubDate":"2020-03-01","recommendState":"","releaseState":"1","secCount":0,"title":"1, 3, 4-噁二唑和1, 3, 4-噻二唑衍生物的设计、合成和生物活性研究","titleCn":"1, 3, 4-噁二唑和1, 3, 4-噻二唑衍生物的设计、合成和生物活性研究","titleEn":"Design, Synthesis and Biological Activities of Compounds Containing 1, 3, 4-Oxadiazole or 1, 3, 4-Thiadiazole","viewCount":180,"volume":"40","year":2020},{"abstractInfo":"采用具有环外双键的二氢苯并呋喃二酮类化合物和氰基亚胺的[3+2]环加成反应,在温和条件下,以高产率(78%~94%)和高非对映选择性(>20:1dr<\/i>)构建了一系列具有螺环结构的吡唑类化合物.","abstractInfoCn":"采用具有环外双键的二氢苯并呋喃二酮类化合物和氰基亚胺的[3+2]环加成反应,在温和条件下,以高产率(78%~94%)和高非对映选择性(>20:1 dr<\/i>)构建了一系列具有螺环结构的吡唑类化合物.","abstractInfoEn":"The[3+2] cycloaddition of methylenedihydrobenzofurandiones and nitrilimines worked efficiently in CHCl3<\/sub> at room temperature in the presence of Et3<\/sub>N, producing biologically interesting spirocyclic pyrazole derivatives in high yield (78%~94%) with excellent diastereoselectivity.","articleNo":"","authorCnList":["史望宇"," 徐嘉擎"," 毛比明"," 贾皓"," 黄家兴"," 郭红超"],"authorEnList":["Shi Wangyu"," Xu Jiaqing"," Mao Biming"," Jia Hao"," Huang Jiaxing"," Guo Hongchao"],"authorList":["史望宇"," 徐嘉擎"," 毛比明"," 贾皓"," 黄家兴"," 郭红超"],"authors":"史望宇, 徐嘉擎, 毛比明, 贾皓, 黄家兴, 郭红超","authorsCn":"史望宇, 徐嘉擎, 毛比明, 贾皓, 黄家兴, 郭红超","authorsEn":"Shi Wangyu, Xu Jiaqing, Mao Biming, Jia Hao, Huang Jiaxing, Guo Hongchao","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"史望宇, 徐嘉擎, 毛比明, 贾皓, 黄家兴, 郭红超. 氰基亚胺与亚甲基二氢苯并呋喃二酮类化合物的[3+2]环加成反应:螺吡唑类化合物的合成. 有机化学, 2020, 40(3): 756-762. doi: 10.6023/cjoc201907030.","citationCn":"史望宇, 徐嘉擎, 毛比明, 贾皓, 黄家兴, 郭红超. 氰基亚胺与亚甲基二氢苯并呋喃二酮类化合物的[3+2]环加成反应:螺吡唑类化合物的合成. 有机化学, 2020, 40(3): 756-762. doi: 10.6023/cjoc201907030.","citationEn":"史望宇, 徐嘉擎, 毛比明, 贾皓, 黄家兴, 郭红超. [3+2] Cycloaddition of Methylenedihydrobenzofurandiones and Nitrilimines: Synthesis of Sipropyrazole Compounds. Chinese Journal of Organic Chemistry, 2020, 40(3): 756-762. doi: 10.6023/cjoc201907030.","doi":"10.6023/cjoc201907030","figContent":"yjhx-40-3-756-S1.jpg$$yjhx-40-3-756-S2.jpg","figList":["yjhx-40-3-756-S1.jpg","yjhx-40-3-756-S2.jpg"],"firstFig":"yjhx-40-3-756-S1.jpg","fpage":"756","highCitedState":"","htmlCount":32,"htmlFile":"","id":"b006847c-e9f0-41d6-952e-1f621bc815ff","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"环加成, 氰基亚胺, 螺环化合物, 吡唑","keywordCn":"环加成, 氰基亚胺, 螺环化合物, 吡唑","keywordCnList":["环加成"," 氰基亚胺"," 螺环化合物"," 吡唑"],"keywordEn":"cycloaddition, nitrilimine, spirocyclic compound, pyrazole","keywordEnList":["cycloaddition"," nitrilimine"," spirocyclic compound"," pyrazole"],"keywordList":["环加成"," 氰基亚胺"," 螺环化合物"," 吡唑"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"762","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":1,"pdfSize":521.97,"pubDate":"2020-03-25","recommendState":"","releaseState":"1","secCount":0,"title":"氰基亚胺与亚甲基二氢苯并呋喃二酮类化合物的[3+2]环加成反应:螺吡唑类化合物的合成","titleCn":"氰基亚胺与亚甲基二氢苯并呋喃二酮类化合物的[3+2]环加成反应:螺吡唑类化合物的合成","titleEn":"[3+2] Cycloaddition of Methylenedihydrobenzofurandiones and Nitrilimines: Synthesis of Sipropyrazole Compounds","viewCount":232,"volume":"40","year":2020},{"abstractInfo":"以聚(9,9-二己烷芴)(1<\/b>)和聚(9,9-二(1-(4-己氧)苯)芴)(2<\/b>)作为参照物,通过Suzuki偶联反应合成了侧链9位碳含有4-己氧基苯和2,4,6-三苯基-1,3,5-三嗪单元的芴共聚物3<\/b>.聚合物1<\/b>,2<\/b>和3<\/b>固体粉末的5%质量热损失温度分别是274,318和401℃,玻璃化转变温度分别是91,120和139℃.聚合物1<\/b>,2<\/b>和3<\/b>在甲苯溶液中的最大吸收峰和荧光发射峰分别在380和435nm.从聚合物1<\/b>到聚合物3<\/b>,薄膜的荧光发射最大半峰宽逐渐降低.大体积刚性吸电子2,4,6-三苯基-1,3,5-三嗪基团的引入,使聚合物1<\/b>,2<\/b>和3<\/b>的热稳定性、蓝光发射的色纯度和光谱稳定性逐渐提高,不同工作电压驱动下聚合物3<\/b>稳定的电致发光光谱进一步证明了这一点.聚合物1<\/b>,2<\/b>和3<\/b>的最高占有轨道能级分别为-5.72,-5.95和-5.96eV,最低未占有轨道能级分别为-2.70,-2.39和-2.43eV.聚合物1<\/b>,2<\/b>和3<\/b>的三线态能级分别为2.82,2.81和2.97eV.聚合物1<\/b>,2<\/b>和3<\/b>的单线态-三线态能级差分别是0.32,0.32和0.15eV.4-己氧基苯的引入使聚合物的能隙变宽,而吸电子的2,4,6-三苯基-1,3,5-三嗪的引入使聚合物单线态-三线态能级差依次减少.聚合物1<\/b>,2<\/b>和3<\/b>粉末均易于形成非晶薄膜.聚合物3<\/b>粉末的有序性介于聚合物1<\/b>和2<\/b>之间,聚合物2<\/b>侧链的烷氧基苯有助于提高固体粉末有序形态的多样化.综合结果表明,侧链含有刚性4-己氧基苯和2,4,6-三苯基-1,3,5-三嗪基团的无规共聚物3<\/b>具有更佳的综合光电性质.","abstractInfoCn":"以聚(9,9-二己烷芴)(1<\/b>)和聚(9,9-二(1-(4-己氧)苯)芴)(2<\/b>)作为参照物,通过Suzuki偶联反应合成了侧链9位碳含有4-己氧基苯和2,4,6-三苯基-1,3,5-三嗪单元的芴共聚物3<\/b>.聚合物1<\/b>,2<\/b>和3<\/b>固体粉末的5%质量热损失温度分别是274,318和401℃,玻璃化转变温度分别是91,120和139℃.聚合物1<\/b>,2<\/b>和3<\/b>在甲苯溶液中的最大吸收峰和荧光发射峰分别在380和435 nm.从聚合物1<\/b>到聚合物3<\/b>,薄膜的荧光发射最大半峰宽逐渐降低.大体积刚性吸电子2,4,6-三苯基-1,3,5-三嗪基团的引入,使聚合物1<\/b>,2<\/b>和3<\/b>的热稳定性、蓝光发射的色纯度和光谱稳定性逐渐提高,不同工作电压驱动下聚合物3<\/b>稳定的电致发光光谱进一步证明了这一点.聚合物1<\/b>,2<\/b>和3<\/b>的最高占有轨道能级分别为-5.72,-5.95和-5.96 eV,最低未占有轨道能级分别为-2.70,-2.39和-2.43 eV.聚合物1<\/b>,2<\/b>和3<\/b>的三线态能级分别为2.82,2.81和2.97 eV.聚合物1<\/b>,2<\/b>和3<\/b>的单线态-三线态能级差分别是0.32,0.32和0.15 eV.4-己氧基苯的引入使聚合物的能隙变宽,而吸电子的2,4,6-三苯基-1,3,5-三嗪的引入使聚合物单线态-三线态能级差依次减少.聚合物1<\/b>,2<\/b>和3<\/b>粉末均易于形成非晶薄膜.聚合物3<\/b>粉末的有序性介于聚合物1<\/b>和2<\/b>之间,聚合物2<\/b>侧链的烷氧基苯有助于提高固体粉末有序形态的多样化.综合结果表明,侧链含有刚性4-己氧基苯和2,4,6-三苯基-1,3,5-三嗪基团的无规共聚物3<\/b>具有更佳的综合光电性质.","abstractInfoEn":"Polymer 3<\/b> based on 1-(4-hexyloxy)-benzene and 2, 4, 6-triphenyl-1, 3, 5-triazine functionalized fluorene units was synthesized and characterized, whose optoelectronic properties were further compared with those of poly(9, 9-dihexyl-fluorene) (1<\/b>) and poly(9, 9-di(1-(4-hexyloxy)-phenyl)-fluorene) (2<\/b>). The 5% weight loss temperatures of polymers 1<\/b>, 2<\/b> and 3<\/b> thin solid powders are 274, 318 and 401℃, and their glass transition temperatures in the same state are 91, 120 and 139℃, respectively. The maximum absorption and photoluminescent emission peaks of polymers 1<\/b>, 2<\/b> and 3<\/b> in toluene solution are 380 and 435 nm, and their optical band gaps in toluene solution are 2.95, 2.95 and 2.91 eV. The triplet energy levels of polymers 1<\/b>, 2<\/b> and 3<\/b> are 2.82, 2.81 and 2.97 eV, while their singlet energy levels are 3.14, 3.13 and 3.12 eV, which makes the singlet-triplet energy splitting gaps for polymers 1<\/b>, 2<\/b> and 3<\/b> to be 0.32, 0.32 and 0.15 eV. The highest occupied molecular orbital energy levels of polymers 1<\/b>, 2<\/b> and 3<\/b> are -5.72, -5.95 and -5.96 eV and the lowest unoccupied molecular orbital energy levels are -2.70, -2.39 and -2.34 eV. The introduction of 4-hexoxybenzene widened the energy band gaps of the polymers, while the electron deficient 2, 4, 6-triphenyl-1, 3, 5-triazine made the single-triplet energy splitting gaps of the polymers successively decreased, but it did not endow polymer 3<\/b> with thermally activated delayed fluorescence characteristic. With the introduction of rigid and electron deficient 2, 4, 6-triphenyl-1, 3, 5-triazine into the 9-carbon of the fluorene units in the polymer, the thermal stability, color purity and photostability of blue light emitting solid were improved in the turn of polymers 1<\/b>, 2<\/b> and 3<\/b>, which were further validated by the stable electroluminescent spectra of polymer 3<\/b>. The wide-angle X-ray diffraction results of the polymers 1<\/b>, 2<\/b> and 3<\/b> powders show that all polymers have excellent amorphous properties in nature. The phase diversity of polymer 3<\/b> powder locates between those of polymers 1<\/b> and 2<\/b>, and the alkoxyl phenyl substituted group on the polymer 2<\/b> side chain is helpful to improve the diversity of ordered morphology in solid powder. The random copolymer 3<\/b> exhibits much better photoelectric properties than those of polymers 1<\/b> and 2<\/b>.","articleNo":"","authorCnList":["姜鸿基"," 何煦"," 李雄"],"authorEnList":["Jiang Hongji"," He Xu"," Li Xiong"],"authorList":["姜鸿基"," 何煦"," 李雄"],"authors":"姜鸿基, 何煦, 李雄","authorsCn":"姜鸿基, 何煦, 李雄","authorsEn":"Jiang Hongji, He Xu, Li Xiong","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"姜鸿基, 何煦, 李雄. 基于1-(4-己氧)苯和2, 4, 6-三苯基-1, 3, 5-三嗪功能化芴单元的聚合物蓝光材料的合成与表征. 有机化学, 2020, 40(3): 763-773. doi: 10.6023/cjoc201905030.","citationCn":"姜鸿基, 何煦, 李雄. 基于1-(4-己氧)苯和2, 4, 6-三苯基-1, 3, 5-三嗪功能化芴单元的聚合物蓝光材料的合成与表征. 有机化学, 2020, 40(3): 763-773. doi: 10.6023/cjoc201905030.","citationEn":"姜鸿基, 何煦, 李雄. Synthesis and Characterization of Blue Light Emitting Polymer Based on 2, 4, 6-Triphenyl-1, 3, 5-triazine and 1-(4-Hexyloxy)-benzene Functionalized Fluorene Units. Chinese Journal of Organic Chemistry, 2020, 40(3): 763-773. doi: 10.6023/cjoc201905030.","doi":"10.6023/cjoc201905030","figContent":"yjhx-40-3-763-S1.jpg$$yjhx-40-3-763-1.jpg$$yjhx-40-3-763-2.jpg$$yjhx-40-3-763-3.jpg$$yjhx-40-3-763-4.jpg$$yjhx-40-3-763-5.jpg$$yjhx-40-3-763-6.jpg$$yjhx-40-3-763-7.jpg$$yjhx-40-3-763-8.jpg","figList":["yjhx-40-3-763-S1.jpg","yjhx-40-3-763-1.jpg","yjhx-40-3-763-2.jpg","yjhx-40-3-763-3.jpg","yjhx-40-3-763-4.jpg","yjhx-40-3-763-5.jpg","yjhx-40-3-763-6.jpg","yjhx-40-3-763-7.jpg","yjhx-40-3-763-8.jpg"],"firstFig":"yjhx-40-3-763-S1.jpg","fpage":"763","highCitedState":"","htmlCount":56,"htmlFile":"","id":"67f39cf7-68c7-4531-9b09-b997d5257101","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"聚芴, 蓝光, 侧基, 2, 4, 6-三苯基-1, 3, 5-三嗪, 光物理, 热稳定性","keywordCn":"聚芴, 蓝光, 侧基, 2, 4, 6-三苯基-1, 3, 5-三嗪, 光物理, 热稳定性","keywordCnList":["聚芴"," 蓝光"," 侧基"," 2"," 4"," 6-三苯基-1"," 3"," 5-三嗪"," 光物理"," 热稳定性"],"keywordEn":"polyfluorene, blue light, pendant group, 2, 4, 6-triphenyl-1, 3, 5-triazine, photo physics, thermal stability","keywordEnList":["polyfluorene"," blue light"," pendant group"," 2"," 4"," 6-triphenyl-1"," 3"," 5-triazine"," photo physics"," thermal stability"],"keywordList":["聚芴"," 蓝光"," 侧基"," 2"," 4"," 6-三苯基-1"," 3"," 5-三嗪"," 光物理"," 热稳定性"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"773","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":0,"pdfSize":4438.32,"pubDate":"2020-03-25","recommendState":"","releaseState":"1","secCount":0,"title":"基于1-(4-己氧)苯和2, 4, 6-三苯基-1, 3, 5-三嗪功能化芴单元的聚合物蓝光材料的合成与表征","titleCn":"基于1-(4-己氧)苯和2, 4, 6-三苯基-1, 3, 5-三嗪功能化芴单元的聚合物蓝光材料的合成与表征","titleEn":"Synthesis and Characterization of Blue Light Emitting Polymer Based on 2, 4, 6-Triphenyl-1, 3, 5-triazine and 1-(4-Hexyloxy)-benzene Functionalized Fluorene Units","viewCount":310,"volume":"40","year":2020}],"研究简报":[{"abstractInfo":"为了发现具有良好生物活性的吡唑肟化合物,以唑螨酯为先导化合物,在吡唑肟中引入取代噁唑结构,设计并制备了20个未见文献报道的新型吡唑肟衍生物,利用1<\/sup>HNMR,13<\/sup>CNMR和元素分析确证了目标产物的结构.生物活性测试结果显示,部分目标化合物在500和100μg/mL浓度下对粘虫或蚜虫表现出优良的杀虫活性,其中5-(3-氟苯氧基)-1,3-二甲基-1H<\/i>-吡唑-4-甲酰基-O<\/i>-{[5-(4-氯苯基)噁唑-2-基]甲基}肟(9j<\/b>)、5-(4-氟苯氧基)-1,3-二甲基-1H<\/i>-吡唑-4-甲酰基-O<\/i>-{[5-(4-氯苯基)噁唑-2-基]甲基}肟(9k<\/b>)、5-(4-叔丁基苯氧基)-1,3-二甲基-1H<\/i>-吡唑-4-甲酰基-O<\/i>-{[5-(4-氯苯基)噁唑-2-基]甲基}肟(9r<\/b>)和5-(4-甲氧基苯氧基)-1,3-二甲基-1H<\/i>-吡唑-4-甲酰基-O<\/i>-{[5-(4-氯苯基)噁唑-2-基]甲基}肟(9s<\/b>)在浓度为100μg/mL时对粘虫的防治效果均达100%,5-(4-溴苯氧基)-1,3-二甲基-1H<\/i>-吡唑-4-甲酰基-O<\/i>-{[5-(4-氟苯基)噁唑-2-基]甲基}肟(9g<\/b>)和9s<\/b>在浓度为100μg/mL时对蚜虫的杀灭活性均为100%.此外,化合物9s<\/b>在500μg/mL时对朱砂叶螨的防治效果为70%.","abstractInfoCn":"为了发现具有良好生物活性的吡唑肟化合物,以唑螨酯为先导化合物,在吡唑肟中引入取代噁唑结构,设计并制备了20个未见文献报道的新型吡唑肟衍生物,利用1<\/sup>H NMR,13<\/sup>C NMR和元素分析确证了目标产物的结构.生物活性测试结果显示,部分目标化合物在500和100 μg/mL浓度下对粘虫或蚜虫表现出优良的杀虫活性,其中5-(3-氟苯氧基)-1,3-二甲基-1H<\/i>-吡唑-4-甲酰基-O<\/i>-{[5-(4-氯苯基)噁唑-2-基]甲基}肟(9j<\/b>)、5-(4-氟苯氧基)-1,3-二甲基-1H<\/i>-吡唑-4-甲酰基-O<\/i>-{[5-(4-氯苯基)噁唑-2-基]甲基}肟(9k<\/b>)、5-(4-叔丁基苯氧基)-1,3-二甲基-1H<\/i>-吡唑-4-甲酰基-O<\/i>-{[5-(4-氯苯基)噁唑-2-基]甲基}肟(9r<\/b>)和5-(4-甲氧基苯氧基)-1,3-二甲基-1H<\/i>-吡唑-4-甲酰基-O<\/i>-{[5-(4-氯苯基)噁唑-2-基]甲基}肟(9s<\/b>)在浓度为100 μg/mL时对粘虫的防治效果均达100%,5-(4-溴苯氧基)-1,3-二甲基-1H<\/i>-吡唑-4-甲酰基-O<\/i>-{[5-(4-氟苯基)噁唑-2-基]甲基}肟(9g<\/b>)和9s<\/b>在浓度为100 μg/mL时对蚜虫的杀灭活性均为100%.此外,化合物9s<\/b>在500 μg/mL时对朱砂叶螨的防治效果为70%.","abstractInfoEn":"In search of novel pyrazole oximes with good biological activities, twenty pyrazole oxime compounds were prepared by introducing an oxazole unit into pyrazole oxime based on the structure of fenpyroximate. The structures of the target compounds were confirmed by 1<\/sup>H NMR, 13<\/sup>C NMR and elemental analysis. Preliminary bioassay displayed that some target compounds had wonderful insecticidal activities against Oriental armyworm<\/i> or Aphis medicaginis<\/i> at the concentrations of 500 and 100 μg/mL. At the concentration of 100 μg/mL, 5-(3-fluorophenoxy)-1, 3-dimethyl-1H<\/i>-pyrazole-4-formyl-O<\/i>-((5-(4-chlo-rophenyl)oxazol-2-yl)methyl)oxime (9j<\/b>), 5-(4-fluorophenoxy)-1, 3-dimethyl-1H<\/i>-pyrazole-4-formyl-O<\/i>-((5-(4-chlorophenyl)-oxazol-2-yl)methyl)oxime (9k<\/b>), 5-(4-t<\/i>-butylphenoxy)-1, 3-dimethyl-1H<\/i>-pyrazole-4-formyl-O<\/i>-((5-(4-chlorophenyl)oxazol-2-yl)methyl)oxime (9r<\/b>) and 5-(4-methoxyphenoxy)-1, 3-dimethyl-1H<\/i>-pyrazole-4-formyl-O<\/i>-((5-(4-chlorophenyl)oxazol-2-yl)me-thyl)oxime (9s<\/b>) showed 100% mortality rate against Oriental armyworm<\/i>, and 5-(4-bromophenoxy)-1, 3-dimethyl-1H<\/i>-pyra-zole-4-formyl-O<\/i>-((5-(4-fluorophenyl)oxazol-2-yl)methyl)oxime (9g<\/b>) and 9s<\/b> exhibited 100% insecticidal property against Aphis medicaginis<\/i>. Additionally, compound 9s<\/b> possessed 70% insecticidal activity against Tetranychus cinnabarinus<\/i> at 500 μg/mL.","articleNo":"","authorCnList":["朱玥"," 郑丹丹"," 倪亚丹"," 李金峰"," 周环宇"," 胡兰萍"," 李玲"," 鞠剑峰"," 陈家正"," 李宏"," 石玉军"," 戴红"],"authorEnList":["Zhu Yue"," Zheng Dandan"," Ni Yadan"," Li Jinfeng"," Zhou Huanyu"," Hu Lanping"," Li Ling"," Ju Jianfeng"," Chen Jiazheng"," Li Hong"," Shi Yujun"," Dai Hong"],"authorList":["朱玥"," 郑丹丹"," 倪亚丹"," 李金峰"," 周环宇"," 胡兰萍"," 李玲"," 鞠剑峰"," 陈家正"," 李宏"," 石玉军"," 戴红"],"authors":"朱玥, 郑丹丹, 倪亚丹, 李金峰, 周环宇, 胡兰萍, 李玲, 鞠剑峰, 陈家正, 李宏, 石玉军, 戴红","authorsCn":"朱玥, 郑丹丹, 倪亚丹, 李金峰, 周环宇, 胡兰萍, 李玲, 鞠剑峰, 陈家正, 李宏, 石玉军, 戴红","authorsEn":"Zhu Yue, Zheng Dandan, Ni Yadan, Li Jinfeng, Zhou Huanyu, Hu Lanping, Li Ling, Ju Jianfeng, Chen Jiazheng, Li Hong, Shi Yujun, Dai Hong","categoryName":"研究简报","categoryNameCn":"研究简报","categoryNameEn":"Notes","citation":"朱玥, 郑丹丹, 倪亚丹, 李金峰, 周环宇, 胡兰萍, 李玲, 鞠剑峰, 陈家正, 李宏, 石玉军, 戴红. 含取代噁唑结构的新型吡唑肟衍生物的合成与生物活性. 有机化学, 2020, 40(3): 774-781. doi: 10.6023/cjoc201910013.","citationCn":"朱玥, 郑丹丹, 倪亚丹, 李金峰, 周环宇, 胡兰萍, 李玲, 鞠剑峰, 陈家正, 李宏, 石玉军, 戴红. 含取代噁唑结构的新型吡唑肟衍生物的合成与生物活性. 有机化学, 2020, 40(3): 774-781. doi: 10.6023/cjoc201910013.","citationEn":"朱玥, 郑丹丹, 倪亚丹, 李金峰, 周环宇, 胡兰萍, 李玲, 鞠剑峰, 陈家正, 李宏, 石玉军, 戴红. Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Bearing an Oxazole Moiety. Chinese Journal of Organic Chemistry, 2020, 40(3): 774-781. doi: 10.6023/cjoc201910013.","doi":"10.6023/cjoc201910013","figContent":"yjhx-40-3-774-1.jpg$$yjhx-40-3-774-2.jpg$$yjhx-40-3-774-S1.jpg","figList":["yjhx-40-3-774-1.jpg","yjhx-40-3-774-2.jpg","yjhx-40-3-774-S1.jpg"],"firstFig":"yjhx-40-3-774-1.jpg","fpage":"774","highCitedState":"","htmlCount":24,"htmlFile":"","id":"a93895b6-02f0-407c-9b45-ec9debf7635d","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"噁唑, 吡唑肟, 合成, 生物活性","keywordCn":"噁唑, 吡唑肟, 合成, 生物活性","keywordCnList":["噁唑"," 吡唑肟"," 合成"," 生物活性"],"keywordEn":"oxazole, pyrazole oxime, synthesis, biological activity","keywordEnList":["oxazole"," pyrazole oxime"," synthesis"," biological activity"],"keywordList":["噁唑"," 吡唑肟"," 合成"," 生物活性"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"781","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":2,"pdfSize":480.66,"pubDate":"2020-03-25","recommendState":"","releaseState":"1","secCount":0,"title":"含取代噁唑结构的新型吡唑肟衍生物的合成与生物活性","titleCn":"含取代噁唑结构的新型吡唑肟衍生物的合成与生物活性","titleEn":"Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Bearing an Oxazole Moiety","viewCount":182,"volume":"40","year":2020},{"abstractInfo":"为了寻找高活性农药先导化合物,以甲霜灵为先导,通过活性基团拼接原理,设计合成了一系列未见文献报道的双酰胺类化合物,其结构经1<\/sup>HNMR、13<\/sup>CNMR和HRMS表征.初步的生物活性测试结果表明:在50mg/L测试浓度下,化合物5j<\/b>对黄瓜霜霉病显示出85%的抑制率;在500mg/L剂量下,多数目标化合物对粘虫表现出较好的杀虫活性,其中化合物5b<\/b>,5f<\/b>,5g<\/b>,5h<\/b>,5i<\/b>,5l<\/b>对粘虫的致死率高达100%,在250mg/L测试浓度下,化合物5f<\/b>,5h<\/b>,5l<\/b>对粘虫的致死率为50%.","abstractInfoCn":"为了寻找高活性农药先导化合物,以甲霜灵为先导,通过活性基团拼接原理,设计合成了一系列未见文献报道的双酰胺类化合物,其结构经1<\/sup>H NMR、13<\/sup>C NMR和HRMS表征.初步的生物活性测试结果表明:在50 mg/L测试浓度下,化合物5j<\/b>对黄瓜霜霉病显示出85%的抑制率;在500 mg/L剂量下,多数目标化合物对粘虫表现出较好的杀虫活性,其中化合物5b<\/b>,5f<\/b>,5g<\/b>,5h<\/b>,5i<\/b>,5l<\/b>对粘虫的致死率高达100%,在250 mg/L测试浓度下,化合物5f<\/b>,5h<\/b>,5l<\/b>对粘虫的致死率为50%.","abstractInfoEn":"In order to find pesticidal lead compounds with high activity, a series of novel diamide compounds were designed and synthesized by using metalaxyl as a leading compound, as well as the principle of active substructure combination. The structures of the target compounds were confirmed by 1<\/sup>H NMR, 13<\/sup>C NMR and HRMS. The preliminary bioassay showed that compound 5j<\/b> showed an 85% inhibition rate against Pseudoperoniospora cubensis<\/i> at 50 mg/L, most of the target compounds had good insecticidal activity against Oriental armyworm<\/i> at 500 mg/L, and compounds 5b<\/b>, 5f<\/b>, 5g<\/b>, 5h<\/b>, 5i<\/b> and 5l<\/b> have a mortality rate of 100% against Oriental armyworm<\/i>. At 250 mg/L, the mortality rate of compounds 5f<\/b>, 5h<\/b> and 5l<\/b> against Oriental armyworm<\/i> was 50%.","articleNo":"","authorCnList":["杨森"," 邹文倩"," 陶敏"," 马天扬"," 刘幸海"," 翁建全"," 谭成侠"],"authorEnList":["Yang Sen"," Zou Wenqian"," Tao Min"," Ma Tianyang"," Liu Xinghai"," Weng Jianquan"," Tan Chengxia"],"authorList":["杨森"," 邹文倩"," 陶敏"," 马天扬"," 刘幸海"," 翁建全"," 谭成侠"],"authors":"杨森, 邹文倩, 陶敏, 马天扬, 刘幸海, 翁建全, 谭成侠","authorsCn":"杨森, 邹文倩, 陶敏, 马天扬, 刘幸海, 翁建全, 谭成侠","authorsEn":"Yang Sen, Zou Wenqian, Tao Min, Ma Tianyang, Liu Xinghai, Weng Jianquan, Tan Chengxia","categoryName":"研究简报","categoryNameCn":"研究简报","categoryNameEn":"Notes","citation":"杨森, 邹文倩, 陶敏, 马天扬, 刘幸海, 翁建全, 谭成侠. 双酰胺类化合物的合成及生物活性研究. 有机化学, 2020, 40(3): 782-786. doi: 10.6023/cjoc201909023.","citationCn":"杨森, 邹文倩, 陶敏, 马天扬, 刘幸海, 翁建全, 谭成侠. 双酰胺类化合物的合成及生物活性研究. 有机化学, 2020, 40(3): 782-786. doi: 10.6023/cjoc201909023.","citationEn":"杨森, 邹文倩, 陶敏, 马天扬, 刘幸海, 翁建全, 谭成侠. Synthesis and Biological Activity of Diamide Compounds. Chinese Journal of Organic Chemistry, 2020, 40(3): 782-786. doi: 10.6023/cjoc201909023.","doi":"10.6023/cjoc201909023","figContent":"yjhx-40-3-782-1.jpg$$yjhx-40-3-782-S1.jpg","figList":["yjhx-40-3-782-1.jpg","yjhx-40-3-782-S1.jpg"],"firstFig":"yjhx-40-3-782-1.jpg","fpage":"782","highCitedState":"","htmlCount":19,"htmlFile":"","id":"20f679bf-f08d-4331-ae63-9a6ffc279b1d","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"双酰胺类化合物, 合成, 生物活性","keywordCn":"双酰胺类化合物, 合成, 生物活性","keywordCnList":["双酰胺类化合物"," 合成"," 生物活性"],"keywordEn":"diamide compound, synthesize, biological activity","keywordEnList":["diamide compound"," synthesize"," biological activity"],"keywordList":["双酰胺类化合物"," 合成"," 生物活性"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"786","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":5,"pdfSize":461.29,"pubDate":"2020-03-25","recommendState":"","releaseState":"1","secCount":0,"title":"双酰胺类化合物的合成及生物活性研究","titleCn":"双酰胺类化合物的合成及生物活性研究","titleEn":"Synthesis and Biological Activity of Diamide Compounds","viewCount":208,"volume":"40","year":2020},{"abstractInfo":"以N<\/i>-吡啶基吡唑甲酸和2-氨基-3-甲基苯甲酸为起始原料,经由亲核加成、环化和酰化等多步反应合成了一系列结构新颖的N<\/i>-(2-(5-(3-溴-1-(3-氯吡啶-2-基)-1H<\/i>-吡唑-5-基)-1,3,4-噁二唑-2-基)-4-氯-6-甲基苯基)酰胺类化合物.测试了所合成化合物的杀虫及抑菌活性,结果表明,新化合物大多化合物在200mg·L-1<\/sup>浓度下对东方粘虫(Mythimnaseparata<\/i>Walker)具有一定的杀虫活性,尤其是N<\/i>-(2-(5-(3-溴-1-(3-氯吡啶-2-基)-1H<\/i>-吡唑-5-基)-1,3,4-噁二唑-2-基)-4-氯-6-甲基苯基)乙酰胺(8a<\/b>)和N<\/i>-(2-(5-(3-溴-1-(3-氯吡啶-2-基)-1H<\/i>-吡唑-5-基)-1,3,4-噁二唑-2-基)-4-氯-6-甲基苯基)-3-氯-2,2-二甲基丙酰胺(8e<\/b>)致死率可达70%;部分化合物在50mg·L-1<\/sup>浓度下对油菜菌核病菌的抑菌活性相对较好(54.5%~63.6%),优于triadimefon和chlorantraniliprole;部分化合物如N<\/i>-(2-(5-(3-溴-1-(3-氯吡啶-2-基)-1H<\/i>-吡唑-5-基)-1,3,4-噁二唑-2-基)-4-氯-6-甲基苯基)-3,3-二甲基丁酰胺(8f<\/b>)和N<\/i>-(2-(5-(3-溴-1-(3-氯吡啶-2-基)-1H<\/i>-吡唑-5-基)-1,3,4-噁二唑-2-基)-4-氯-6-甲基苯基)-4-氟苯甲酰胺(8h<\/b>)对苹果轮纹病菌具有中等抑菌活性.值得注意的是,化合物8e<\/b>的杀粘虫活性和对油菜菌核病菌的抑菌活性都较为突出,可用作新农药创制研究的新型参考结构.","abstractInfoCn":"以N<\/i>-吡啶基吡唑甲酸和2-氨基-3-甲基苯甲酸为起始原料,经由亲核加成、环化和酰化等多步反应合成了一系列结构新颖的N<\/i>-(2-(5-(3-溴-1-(3-氯吡啶-2-基)-1H<\/i>-吡唑-5-基)-1,3,4-噁二唑-2-基)-4-氯-6-甲基苯基)酰胺类化合物.测试了所合成化合物的杀虫及抑菌活性,结果表明,新化合物大多化合物在200 mg·L-1<\/sup>浓度下对东方粘虫(Mythimna separata<\/i> Walker)具有一定的杀虫活性,尤其是N<\/i>-(2-(5-(3-溴-1-(3-氯吡啶-2-基)-1H<\/i>-吡唑-5-基)-1,3,4-噁二唑-2-基)-4-氯-6-甲基苯基)乙酰胺(8a<\/b>)和N<\/i>-(2-(5-(3-溴-1-(3-氯吡啶-2-基)-1H<\/i>-吡唑-5-基)-1,3,4-噁二唑-2-基)-4-氯-6-甲基苯基)-3-氯-2,2-二甲基丙酰胺(8e<\/b>)致死率可达70%;部分化合物在50 mg·L-1<\/sup>浓度下对油菜菌核病菌的抑菌活性相对较好(54.5%~63.6%),优于triadimefon和chlorantraniliprole;部分化合物如N<\/i>-(2-(5-(3-溴-1-(3-氯吡啶-2-基)-1H<\/i>-吡唑-5-基)-1,3,4-噁二唑-2-基)-4-氯-6-甲基苯基)-3,3-二甲基丁酰胺(8f<\/b>)和N<\/i>-(2-(5-(3-溴-1-(3-氯吡啶-2-基)-1H<\/i>-吡唑-5-基)-1,3,4-噁二唑-2-基)-4-氯-6-甲基苯基)-4-氟苯甲酰胺(8h<\/b>)对苹果轮纹病菌具有中等抑菌活性.值得注意的是,化合物8e<\/b>的杀粘虫活性和对油菜菌核病菌的抑菌活性都较为突出,可用作新农药创制研究的新型参考结构.","abstractInfoEn":"A series of novel aromatic amide compounds with N<\/i>-pyridylpyrazole and 1, 3, 4-oxadiazole heterocyclic motifs were successfully synthesized with N<\/i>-pyridylpyrazole carboxylic acid and 2-amino-3-methylbenzoic acid as the starting materials, via multi-step reactions of nucleophilic addition, cyclization, acylation, etc<\/i>. The preliminary bioassay tests indicated that most of these compounds have apparent insecticidal activities, among which compounds N<\/i>-(2-(5-(3-bromo-1-(3-chloropyridin-2-yl)-1H<\/i>-pyrazol-5-yl)-1, 3, 4-oxadiazol-2-yl)-4-chloro-6-methylphenyl)acetamide (8a<\/b>) and N<\/i>-(2-(5-(3-bromo-1-(3-chloro-pyridin-2-yl)-1H<\/i>-pyrazol-5-yl)-1, 3, 4-oxadiazol-2-yl)-4-chloro-6-methylphenyl)-3-chloro-2, 2-dimethylpropanamide (8e<\/b>) possessed a mortality rate of 70% towards Mythimna separata<\/i> Walker at the concentration of 200 mg·L-1<\/sup>. Some of the compounds exhibited good fungicidal activities at 50 mg·L-1<\/sup> against Sclerotinia sclerotiorum<\/i> with the growth inhibitory rates of 54.5%~63.6%, which is more effective than the controls of triadimefon and chlorantraniliprole. Several compounds such as N<\/i>-(2-(5-(3-bromo-1-(3-chloropyridin-2-yl)-1H<\/i>-pyrazol-5-yl)-1, 3, 4-oxadiazol-2-yl)-4-chloro-6-methylphenyl)pivalamide (8f<\/b>) and N<\/i>-(2-(5-(3-bromo-1-(3-chloropyridin-2-yl)-1H<\/i>-pyrazol-5-yl)-1, 3, 4-oxadiazol-2-yl)-4-chloro-6-methylphenyl)-4-fluoroben-zamide (8h<\/b>) showed moderate fungicidal activity against Physalospora piricola<\/i>. It is worth noting that compound 8e<\/b>, which has favorable insecticidal and fungicidal activities towards Mythimna separata<\/i> Walker and Sclerotinia sclerotiorum<\/i> respectively, could be used as novel reference structure for new agrochemical innovations.","articleNo":"","authorCnList":["张燕"," 尚俊峰"," 李欢"," 刘航"," 宋海斌"," 王宝雷"," 李正名"],"authorEnList":["Zhang Yan"," Shang Junfeng"," Li Huan"," Liu Hang"," Song Haibin"," Wang Baolei"," Li Zhengming"],"authorList":["张燕"," 尚俊峰"," 李欢"," 刘航"," 宋海斌"," 王宝雷"," 李正名"],"authors":"张燕, 尚俊峰, 李欢, 刘航, 宋海斌, 王宝雷, 李正名","authorsCn":"张燕, 尚俊峰, 李欢, 刘航, 宋海斌, 王宝雷, 李正名","authorsEn":"Zhang Yan, Shang Junfeng, Li Huan, Liu Hang, Song Haibin, Wang Baolei, Li Zhengming","categoryName":"研究简报","categoryNameCn":"研究简报","categoryNameEn":"Notes","citation":"张燕, 尚俊峰, 李欢, 刘航, 宋海斌, 王宝雷, 李正名. N<\/i>-(2-(5-(3-溴-1-(3-氯吡啶-2-基)-1H<\/i>-吡唑-5-基)-1, 3, 4-噁二唑-2-基)-4-氯-6-甲基苯基)酰胺类新化合物的合成及生物活性. 有机化学, 2020, 40(3): 787-793. doi: 10.6023/cjoc201908024.","citationCn":"张燕, 尚俊峰, 李欢, 刘航, 宋海斌, 王宝雷, 李正名. N<\/i>-(2-(5-(3-溴-1-(3-氯吡啶-2-基)-1H<\/i>-吡唑-5-基)-1, 3, 4-噁二唑-2-基)-4-氯-6-甲基苯基)酰胺类新化合物的合成及生物活性. 有机化学, 2020, 40(3): 787-793. doi: 10.6023/cjoc201908024.","citationEn":"张燕, 尚俊峰, 李欢, 刘航, 宋海斌, 王宝雷, 李正名. Synthesis and Biological Activities of Novel N<\/i>-(2-(5-(3-Bromo-1-(3-chloropyridin-2-yl)-1H<\/i>-pyrazol-5-yl)-1, 3, 4-oxadiazol-2-yl)-4-chloro-6-methylphenyl) Amides. Chinese Journal of Organic Chemistry, 2020, 40(3): 787-793. doi: 10.6023/cjoc201908024.","doi":"10.6023/cjoc201908024","figContent":"yjhx-40-3-787-S1.jpg$$yjhx-40-3-787-S2.jpg$$yjhx-40-3-787-S3.jpg$$yjhx-40-3-787-1.jpg","figList":["yjhx-40-3-787-S1.jpg","yjhx-40-3-787-S2.jpg","yjhx-40-3-787-S3.jpg","yjhx-40-3-787-1.jpg"],"firstFig":"yjhx-40-3-787-S1.jpg","fpage":"787","highCitedState":"","htmlCount":39,"htmlFile":"","id":"c99797d5-1403-4e7d-9a14-e0c5b085a146","issnPpub":"0253-2786","issue":"3","journalPublishId":"YJHX","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"N<\/i>-吡啶基吡唑衍生物, 1, 3, 4-噁二唑, 合成, 杀虫活性, 抑菌活性","keywordCn":"N<\/i>-吡啶基吡唑衍生物, 1, 3, 4-噁二唑, 合成, 杀虫活性, 抑菌活性","keywordCnList":["N<\/i>-吡啶基吡唑衍生物"," 1"," 3"," 4-噁二唑"," 合成"," 杀虫活性"," 抑菌活性"],"keywordEn":"N<\/i>-pyridylpyrazole derivatives, 1, 3, 4-oxadiazole, synthesis, insecticidal activity, fungicidal activity","keywordEnList":["N<\/i>-pyridylpyrazole derivatives"," 1"," 3"," 4-oxadiazole"," synthesis"," insecticidal activity"," fungicidal activity"],"keywordList":["N<\/i>-吡啶基吡唑衍生物"," 1"," 3"," 4-噁二唑"," 合成"," 杀虫活性"," 抑菌活性"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"793","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":4,"pdfSize":744.26,"pubDate":"2020-03-25","recommendState":"","releaseState":"1","secCount":0,"title":"N<\/i>-(2-(5-(3-溴-1-(3-氯吡啶-2-基)-1H<\/i>-吡唑-5-基)-1, 3, 4-噁二唑-2-基)-4-氯-6-甲基苯基)酰胺类新化合物的合成及生物活性","titleCn":"N<\/i>-(2-(5-(3-溴-1-(3-氯吡啶-2-基)-1H<\/i>-吡唑-5-基)-1, 3, 4-噁二唑-2-基)-4-氯-6-甲基苯基)酰胺类新化合物的合成及生物活性","titleEn":"Synthesis and Biological Activities of Novel N<\/i>-(2-(5-(3-Bromo-1-(3-chloropyridin-2-yl)-1H<\/i>-pyrazol-5-yl)-1, 3, 4-oxadiazol-2-yl)-4-chloro-6-methylphenyl) Amides","viewCount":236,"volume":"40","year":2020},{"abstractInfo":"为了寻找高效低毒的抗肿瘤药物,设计并合成新型的1,3位取代酞嗪酮类化合物.采用噻唑蓝(MTT)法对目标化合物在MCF-7(人乳腺癌细胞)、PC-3(人前列腺癌细胞)、SW-620(人结肠癌细胞)和HGC-27(人胃癌细胞)四种人类癌细胞的抗增殖活性进行评价.结果显示大部分化合物具有较好的抗增殖活性.其中,2-(4-(4-溴苯基)-1-氧代酞嗪-2(1H<\/i>)-基)-N<\/i>-(2-氟苯基)乙酰胺(5g<\/b>)对MCF-7细胞的抗增殖活性较好,IC50<\/sub>值为6.01μmol/L,为抗肿瘤药物的研究提供了思路.","abstractInfoCn":"为了寻找高效低毒的抗肿瘤药物,设计并合成新型的1,3位取代酞嗪酮类化合物.采用噻唑蓝(MTT)法对目标化合物在MCF-7(人乳腺癌细胞)、PC-3(人前列腺癌细胞)、SW-620(人结肠癌细胞)和HGC-27(人胃癌细胞)四种人类癌细胞的抗增殖活性进行评价.结果显示大部分化合物具有较好的抗增殖活性.其中,2-(4-(4-溴苯基)-1-氧代酞嗪-2(1H<\/i>)-基)-N<\/i>-(2-氟苯基)乙酰胺(5g<\/b>)对MCF-7细胞的抗增殖活性较好,IC50<\/sub>值为6.01 μmol/L,为抗肿瘤药物的研究提供了思路.","abstractInfoEn":"In order to find more efficient and low toxicity antitumor drugs, a series of novel 1, 3-disubstituted pyridazinone derivatives were synthesized and evaluated for their antiproliferative activities against four human cancer cell lines (MCF-7, PC-3, SW-620 and HGC-27) in vitro<\/i>. The results showed that most compounds had good antiproliferative activities, especially 2-(4-(4-bromophenyl)-1-oxo-tolylazine-2(1H<\/i>)-yl)-N<\/i>-(2-fluorophenyl)acetamide (5g<\/b>) exhibited better antiproliferative activities with IC50<\/sub> value of 6.01 μmol/L. In a nutshell, this work provided clues to discover antitumor agent based on the quinazoline scaffold.","articleNo":"","authorCnList":["张路野"," 张洋"," 包崇男"," 杨鹏"," 李二冬"," 孟娅琪"," 崔飞"," 周蕊"," 黄诗雨"," 郑甲信"," 单丽红"," 刘宏民"," 张秋荣"],"authorEnList":["Zhang Luye"," Zhang Yang"," Bao Chongnan"," Yang Peng"," Li Erdong"," Meng Yaqi"," Cui Fei"," Zhou Rui"," Huang Shiyu"," Zheng Jiaxin"," Shan Lihong"," Liu Hongmin"," Zhang Qiurong"],"authorList":["张路野"," 张洋"," 包崇男"," 杨鹏"," 李二冬"," 孟娅琪"," 崔飞"," 周蕊"," 黄诗雨"," 郑甲信"," 单丽红"," 刘宏民"," 张秋荣"],"authors":"张路野, 张洋, 包崇男, 杨鹏, 李二冬, 孟娅琪, 崔飞, 周蕊, 黄诗雨, 郑甲信, 单丽红, 刘宏民, 张秋荣","authorsCn":"张路野, 张洋, 包崇男, 杨鹏, 李二冬, 孟娅琪, 崔飞, 周蕊, 黄诗雨, 郑甲信, 单丽红, 刘宏民, 张秋荣","authorsEn":"Zhang Luye, Zhang Yang, Bao Chongnan, Yang Peng, Li Erdong, Meng Yaqi, Cui Fei, Zhou Rui, Huang Shiyu, Zheng Jiaxin, Shan Lihong, Liu Hongmin, Zhang Qiurong","categoryName":"研究简报","categoryNameCn":"研究简报","categoryNameEn":"Notes","citation":"张路野, 张洋, 包崇男, 杨鹏, 李二冬, 孟娅琪, 崔飞, 周蕊, 黄诗雨, 郑甲信, 单丽红, 刘宏民, 张秋荣. 新型1, 3-二取代酞嗪酮类衍生物的合成及抗肿瘤活性研究. 有机化学, 2020, 40(3): 794-800. doi: 10.6023/cjoc201908012.","citationCn":"张路野, 张洋, 包崇男, 杨鹏, 李二冬, 孟娅琪, 崔飞, 周蕊, 黄诗雨, 郑甲信, 单丽红, 刘宏民, 张秋荣. 新型1, 3-二取代酞嗪酮类衍生物的合成及抗肿瘤活性研究. 有机化学, 2020, 40(3): 794-800. doi: 10.6023/cjoc201908012.","citationEn":"张路野, 张洋, 包崇男, 杨鹏, 李二冬, 孟娅琪, 崔飞, 周蕊, 黄诗雨, 郑甲信, 单丽红, 刘宏民, 张秋荣. Synthesis and Antitumor Activity of Novel 1, 3-Disubstituted Pyridazinone Derivatives. 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