Citation: Sun Shangzheng, Wang Xing, Cheng Taijin, Xu Hui, Dai Huixiong. Cu(II)-Mediated β-C—H Alkynylation of Acrylamides with Terminal Alkynes[J]. Chinese Journal of Organic Chemistry, ;2020, 40(10): 3371-3379. doi: 10.6023/cjoc202005064 shu

Cu(II)-Mediated β-C—H Alkynylation of Acrylamides with Terminal Alkynes

Sun Shangzheng ^c ,
Wang Xing ^a,b ,
Cheng Taijin ^a,b ,
Xu Hui ^a,b ,
Dai Huixiong ^a,b,,

a.
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203
b.
University of Chinese Academy of Sciences, Beijing 100049
c.
Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai 200444

Corresponding author: Dai Huixiong,
Received Date: 23 May 2020
Revised Date: 20 June 2020
Available Online: 8 July 2020
Fund Project: the Science and Technology Commission of Shanghai Municipality 17JC1405000the National Natural Science Foundation of China 21772211Project supported by the National Natural Science Foundation of China (No. 21772211), the Youth Innovation Promotion Association CAS (Nos. 2014229, 2018293), and the Science and Technology Commission of Shanghai Municipality (No. 17JC1405000)the Youth Innovation Promotion Association CAS 2014229the Youth Innovation Promotion Association CAS 2018293

Figures(4)

Cu(Ⅱ)-mediated β-C-H alkynylation of acrylamides with terminal alkynes is described by employing amide-oxazoline bidentate auxiliary, forming the conjugated 1, 3-enynes. This protocol is characterized by its mild conditions, broad substarate scope and excellent regio- and stereo-selectivity.
- β-C-H alkynylation,
- copper,
- 1, 3-enynes,
- stereo-selectivity
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