Citation: Li Mengfan, Wang Rong, Hao Wenjuan, Jiang Bo. Electrocatalytic Synthesis of 2, 5-Disubstituted 1, 3, 4-Oxadiazoles[J]. Chinese Journal of Organic Chemistry, ;2020, 40(6): 1540-1548. doi: 10.6023/cjoc202002029 shu

Electrocatalytic Synthesis of 2, 5-Disubstituted 1, 3, 4-Oxadiazoles

School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116

Corresponding author: Jiang Bo, jiangchem@jsnu.edu.cn
Received Date: 23 February 2020
Revised Date: 26 March 2020
Available Online: 10 April 2020
Fund Project: the National Natural Science Foundation of China 21971090the Postgraduate Research Innovation Program of Jiangsu Province SJKY19_2003Project supported by the National Natural Science Foundation of China (No. 21971090), and the Postgraduate Research Innovation Program of Jiangsu Province (No. SJKY19_2003)

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1, 3, 4-Oxadiazoles, standing for a class of five-membered heterocyclic compounds with multiple heteroatoms, show anti-inflammatory, anti-convulsant, anti-inositol and other biological activities. They also served as important intermediates in organic synthesis. Thus, the development of general and straightforward methods for their synthesis is of great significance. In this paper one-step synthesis of non-symmetric 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives with good yield was completed under electrocatalytic conditions by using cheap and readily available aldehydes and hydrazides as starting materials. Their structures were confirmed by IR, ¹H NMR, ¹³C NMR and HRMS analyses. The reaction features mild conditions, high atom-economy and wide substrate scope, providing a green and sustainable synthetic protocol for constructing 1, 3, 4-oxadiazole skeleton.
- chemistry,
- 1, 3, 4-oxadiazoles,
- electrosynthesis,
- radcial cyclization
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