Citation: Zhang Wenwen, Wang Zixuan, Bai Xiaoyan, Li Bijie. Substrate-Directed Catalytic Asymmetric Hydroalkynylation of Alkenes[J]. Chinese Journal of Organic Chemistry, ;2020, 40(5): 1087-1095. doi: 10.6023/cjoc202002017 shu

Substrate-Directed Catalytic Asymmetric Hydroalkynylation of Alkenes

Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing 100084

Corresponding author: Li Bijie, bijieli@mail.tsinghua.edu.cn
Received Date: 16 February 2020
Revised Date: 8 March 2020
Available Online: 31 May 2020
Fund Project: Project supported by the Thousand Young Talents Program

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Catalytic asymmetric hydrofunctionalization of alkene is an important research field, which enables efficient construction of chiral molecules from readily available starting materials. Asymmetric hydrofunctionalization of multiple substituted alkenes represents a significant challenge to organic chemists because this process involves the simutaneous control of regio-, diastereo-, and enantio-selectivities. The key to solve this challenge is to identify novel catalyst systems to exert powerful regio- and stereo-control. Recently, by taking advantage of substrate-directed strategy, we have developed a number of alkene functionalization methods with excellent regio-, diastereo-, and enantio-selectivities. In particular, we focus on catalytic asymmetric hydroalkynylation of alkenes as a model transformation to analyze the factors that control the selectivity.
- alkene functionalization,
- asymmetric catalysis,
- selectivity,
- substrate-directed strategy,
- transition metal catalysis
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