Citation: ChenZhang Pengfei, Lan Wenjie, Yu Xuan, Fu Bin. New Application of β, γ-Unsaturated α-Ketoesters in Asymmetric Catalysis[J]. Chinese Journal of Organic Chemistry, ;2020, 40(6): 1448-1460. doi: 10.6023/cjoc202001019 shu

New Application of β, γ-Unsaturated α-Ketoesters in Asymmetric Catalysis

College of Science, China Agricultural University, Beijing 100193

Corresponding author: Fu Bin, fubinchem@cau.edu.cn
Received Date: 13 January 2020
Revised Date: 14 March 2020
Available Online: 31 March 2020
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21572265) and the Ministry of Science and Technology of China (No. 2015BAK45B01)the Ministry of Science and Technology of China 2015BAK45B01the National Natural Science Foundation of China 21572265

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β, γ-Unsaturated α-ketoester is a class of polyfunctional synthon. Due to its 1, 2-dicarbonyl structure and multiple reactive sites, it has been used for the synthesis of various compounds. In the past twenty years, a number of chiral Lewis acid catalysts and organocatalysts have been applied to asymmetric catalytic reactions using β, γ-unsaturated α-ketoesters and various optically active compounds have been synthesized. The current progress of β, γ-unsaturated α-ketoesters in asymmetric catalysis according to the three different reaction sites, unsaturated acyl conjugate system, carbon-carbon double bond and carbonyl group, is summarized. Finally, the limitation of related reactions and the future development trends are also pointed out.
- β, γ-unsaturated α-ketoester,
- asymmetric catalysis,
- application
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