Citation: Shi Lei, Li Ziqiu, Cui Xinxin, Zhu Ting, Pang Xiaojing, Li Longhui, Luo Defu, Liu Fangfang, Zhao Bingyu, Long Yue, Zhang Saiyang. Synthesis and Anticancer Activity of Novel Coumarin Derivatives[J]. Chinese Journal of Organic Chemistry, ;2020, 40(6): 1598-1607. doi: 10.6023/cjoc201911028 shu

Synthesis and Anticancer Activity of Novel Coumarin Derivatives

Shi Lei ^a ,
Li Ziqiu ^a ,
Cui Xinxin ^b ,
Zhu Ting ^b ,
Pang Xiaojing ^b ,
Li Longhui ^a ,
Luo Defu ^a ,
Liu Fangfang ^b ,
Zhao Bingyu ^b ,
Long Yue ^a,, ,
Zhang Saiyang ^c,,

a.
College of Chemistry, Zhengzhou University, Zhengzhou 450001
b.
School of Pharmaceutical Sciences, Zhengzhou 450001
c.
School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001

Corresponding author: Long Yue, longyue@zzu.edu.cn Zhang Saiyang, saiyangz@zzu.edu.cn
Received Date: 23 November 2019
Revised Date: 15 January 2020
Available Online: 9 April 2020
Fund Project: Project supported by the National Natural Sciences Foundations of China (Nos. 81703541, 81673322) and the China Postdoctoral Science Foundation (No. 2018M632812)the National Natural Sciences Foundations of China 81673322the China Postdoctoral Science Foundation 2018M632812the National Natural Sciences Foundations of China 81703541

Figures(2)

Nineteen novel 3, 4, 5-trimethoxyphenyl coumarin derivatives have been synthesized and evaluated for antitumor activity against three human cancer cell lines (EC-109, PC-3 and MGC-803). These chemical structures were well characterized by NMR and HRMS spectroscopic methods. N-Benzyl-2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)-N-(3, 4, 5-trimethoxy-phenyl)acetamide) (4a) and N-((5-chlorobenzo[b]thiophen-3-yl)methyl)-2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)-N-(3, 4, 5-trimethoxyphenyl)acetamide) (4n) had better inhibitory activity against three kinds of tumor cells than 5-fluorouracil. Compound 4n showed the most potent antitumor activity against PC-3 cells with an IC₅₀ value of 4.18 μmol/L.
- coumarin,
- anticancer,
- synthesis
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