Citation: Zhang Yongna, Duan Hui-Xin, Wang You-Qing. Research Progress in Asymmetric Reactions of Imines Using Chiral Primary Amines as Organocatalysts[J]. Chinese Journal of Organic Chemistry, ;2020, 40(6): 1514-1528. doi: 10.6023/cjoc201908030 shu

Research Progress in Asymmetric Reactions of Imines Using Chiral Primary Amines as Organocatalysts

College of Chemistry and Chemical Engineering, Henan Key Laboratory of Polyoxometalate Chemistry, Provincial Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng, Henan 475004

Corresponding author: Zhang Yongna, zhangyongna@henu.edu.cn Wang You-Qing, wyouqing@hotmail.com
Received Date: 22 August 2019
Revised Date: 1 November 2019
Available Online: 29 February 2020
Fund Project: Project supported by the National Natural Science Foundation of China (No. U1404211), and the Key Scientific and Technological Research Projects of Henan Education Department (No. 14A150029)the Key Scientific and Technological Research Projects of Henan Education Department 14A150029the National Natural Science Foundation of China U1404211

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Chiral primary amine is a kind of important small organic molecule catalyst in the field of asymmetric organocatalysis. Like secondary amine catalyst, primary amine can react with carbonyl compounds to form reactive intermediate of enamine or iminium to catalyze various asymmetric reactions, achieving excellent enantioselectivities. The catalytic asymmetric 1, 2-addition to the electrophilic C=N double bond of imines (involving imine intermediates in the reaction process) is the most efficient way to obtain nitrogen-containing compounds bearing α-chiral center. In recent years, the highly enantioselective asymmetric reaction of imines by chiral primary amine catalysts has made some progress, so this topic is summarized and prospected.
- chirality,
- primary amines,
- imines,
- asymmetric catalysis,
- organocatalysts
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