Citation: Zhang Yunxi, Gao Huchuan, Zhang Chenrui, Sun Maosheng, Chen Yangjie, Zeng Lisheng, Huang Lan, Chen Peng, Huang Qianming, Pu Xiang. Advances in the Study of Structural Modification of Aspirin and Their Biological Activities[J]. Chinese Journal of Organic Chemistry, ;2020, 40(2): 300-326. doi: 10.6023/cjoc201907055 shu

Advances in the Study of Structural Modification of Aspirin and Their Biological Activities

College of Science, Sichuan Agricultural University, Ya'an, Sichuan 625014

Corresponding author: Pu Xiang, puxiang@sicau.edu.cn
Received Date: 31 July 2019
Revised Date: 20 October 2019
Available Online: 7 February 2019
Fund Project: the National Natural Science Foundation of China 21708028the Education Department of Sichuan Province 17ZA0301the Scientific Innovation Cultivation Project of Sichuan Province 2018080Project supported by the National Natural Science Foundation of China (No. 21708028), the Education Department of Sichuan Province (No. 17ZA0301) and the Scientific Innovation Cultivation Project of Sichuan Province (No. 2018080)

Figures(40)

Aspirin (ASP), the first synthetic drug, is widely used as a non steroidal anti-inflammatory drug. It displays a variety of biological activities, such as anti-thrombosis, anti-inflammatory, anti-tumor, etc. A lot of works about the synthesis and related activity evaluation of its derivatives were reported. There are four kinds of derivatization methods:skeleton derivatization, prodrug derivatization, twin derivatization and metal coordination derivatization. According to the different modification sites, skeleton derivatization could be further divided into C(1)-COOH site modification, C(1)-COOH site and C(2)-OAc site simultaneous modification, C(2)-OAc site modification and benzene ring modification. NO-ASP is the main method to prepare antithrombotic derivatives, and metal coordination modification is the main synthesis scheme of anticancer derivatives. The structure modification and bioactivity research of aspirin in recent twenty years and the synthetic routes of 353 aspirin derivatives and the pharmacological activities of some derivatives are described, which provides a reference for the further development of aspirin derivatives.
- aspirin,
- skeleton derivation,
- prodrug derivation,
- twin drug derivation,
- metal coordination derivation
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沈阳化工大学材料科学与工程学院沈阳 110142