Citation: Shi Zhan, Nie Kerui, Liu Chang, Zhang Mingzhi, Zhang Weihua. Biological Activities of 3-(5-Oxazolyl)indole Natural Products and Advances on Synthesis of Its Derivatives[J]. Chinese Journal of Organic Chemistry, ;2020, 40(2): 327-338. doi: 10.6023/cjoc201907047 shu

Biological Activities of 3-(5-Oxazolyl)indole Natural Products and Advances on Synthesis of Its Derivatives

Shi Zhan ^a,b ,
Nie Kerui ^a ,
Liu Chang ^a ,
Zhang Mingzhi ^a,, ,
Zhang Weihua ^a,,

a.
College of Sciences, Nanjing Agricutural University, Nanjing 210095
b.
Department of Chemistry, Fudan University, Shanghai 200433

Corresponding author: Zhang Mingzhi, mzzhang@njau.edu.cn Zhang Weihua, zhwh@njau.edu.cn
Received Date: 28 July 2019
Revised Date: 3 October 2019
Available Online: 7 February 2019
Fund Project: the National Key R&D Program of China 2018YFC1602804the Jiangsu Provincial Science Foundation for Youths BK20160734the Fundamental Research Funds for the Central Universities KYTZ201604the National Natural Science Foundation of China 21602110Project supported by the National Natural Science Foundation of China (No. 21602110), the National Key R&D Program of China (No. 2018YFC1602804), the Jiangsu Provincial Science Foundation for Youths (No. BK20160734) and the Fundamental Research Funds for the Central Universities (Nos. KYTZ201604, KYLH201908)the Fundamental Research Funds for the Central Universities KYLH201908

Figures(32)

3-(5-Oxazolyl)indole-type natural products such as pimprinine and streptochlorin, widely exist in marine microorganism, because of their diverse biological activity, 3-(5-oxazolyl)indoles show good research and development potential in the field of medicine and pesticide. Numerous studies have been performed to synthesize 3-(5-oxazolyl)indole-type natural products, in which the construction of indole ring and oxazole ring is the most important part. In this paper, the reported natural products with 3-(5-oxazolyl)indole skeleton structure and their biological activities are summarized, and the synthetic methods for 3-(5-oxazolyl)indole skeleton and some of their mechanism are also reviewed. The application prospect of 3-(5-oxazol-yl)indole as a dominant active structure in the future was discussed.
- 3-(5-oxazolyl)indole,
- natural products,
- biological activities,
- synthesis,
- review
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