Citation: Guo Dongdong, Zhang Wuxia, Gao Weimei, Guo Xiaodi, Wang Yongqiang. Total Synthesis of Pulchrol and Pulchral[J]. Chinese Journal of Organic Chemistry, ;2019, 39(10): 2936-2940. doi: 10.6023/cjoc201907024 shu

Total Synthesis of Pulchrol and Pulchral

a.
College of Arts and Sciences, Shanxi Agricultural University, Taigu 030801, Shanxi
b.
Department of Chemistry & Materials Science, Northwest University, Xi'an 710069

Corresponding author: Wang Yongqiang, wangyq@nwu.edu.cn
Received Date: 17 July 2019
Revised Date: 20 August 2019
Available Online: 5 October 2019
Fund Project: the Science and Technology Innovation Project of Shanxi Agricultural University 2017YJ41Project supported by the National Natural Science Foundation of China (No. 31800678), the Science and Technology Research Project in ShanXi Province (Nos. 201801D221062, 201801D221063), the Shanxi Excellent Doctor Grant Award (Nos. SXYBKY201737, SXYBKY201706), and the Science and Technology Innovation Project of Shanxi Agricultural University (Nos. 2017YJ38, 2017YJ41)the Shanxi Excellent Doctor Grant Award SXYBKY201737the Science and Technology Innovation Project of Shanxi Agricultural University 2017YJ38the Science and Technology Research Project in ShanXi Province 201801D221062the Shanxi Excellent Doctor Grant Award SXYBKY201706the National Natural Science Foundation of China 31800678the Science and Technology Research Project in ShanXi Province 201801D221063

Figures(3)

The total synthesis of natural products pulchrol and pulchral with antiprotozoan activity was reported, starting from the cheap hydroquinone and 4-methylbenzoic acid and using palladium-catalyzed intramolecular decarboxylation coupling reaction of arene carboxylic acids with aryl bromides as the key reaction. This method provides an opportunity for further study of the structure-activity relationship.
- natural product,
- total synthesis,
- cross-coupling,
- pulchrol,
- pulchral
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沈阳化工大学材料科学与工程学院沈阳 110142