Citation: Zhao Yating, Zeng Junjie, Xia Wujiong. Visible-Light-Induced α-C(sp³)—H Amination Reactions of Tertiary Amines[J]. Chinese Journal of Organic Chemistry, ;2020, 40(1): 133-139. doi: 10.6023/cjoc201907002 shu

Visible-Light-Induced α-C(sp³)—H Amination Reactions of Tertiary Amines

Zhao Yating ^a,b,, ,
Zeng Junjie ^b ,
Xia Wujiong ^b,,

a.
College of Chemical and Material Engineering, Quzhou University, Quzhou, Zhejiang 324000
b.
State Key Laboratory of Urban Water Resource and Environment, School of Science, Harbin Institute of Technology[Shenzhen], Shenzhen, Guangdong 518055

Corresponding author: Zhao Yating, liveagain@126.com Xia Wujiong, xiawj@hit.edu.cn
Received Date: 2 July 2019
Revised Date: 20 August 2019
Available Online: 5 January 2019
Fund Project: the Start-up Funds of Quzhou University BSYJ201714Project supported by the National Natural Science Foundation of China (Nos. 21901141, 21672047), and the Start-up Funds of Quzhou University (No. BSYJ201714)the National Natural Science Foundation of China 21672047the National Natural Science Foundation of China 21901141

Figures(4)

Herein, the visible-light-induced α-C(sp³)—H amination reactions of tertiary amines were reported. By using readily available 1, 3-dioxoisoindolin-2-yl benzoate as precursor of N-radical and blue LEDs as green and sustainable energy source, the α-C(sp³)—H bonds of various N, N-dimethylaniline derivatives were aminated directly. Based on radical trapping experiment and documented literature, a mechanism involving radicals coupling was proposed. This method featured in mild reaction conditions and good functional group tolerance, which provides a simple and practical protocol to the modification of tertiary amines.
- photoredox catalysis,
- N-radical,
- amination reaction,
- C—H functionalization,
- radicals coupling
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沈阳化工大学材料科学与工程学院沈阳 110142

Visible-Light-Induced α-C(sp3)—H Amination Reactions of Tertiary Amines

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Visible-Light-Induced α-C(sp³)—H Amination Reactions of Tertiary Amines