Citation: Zhang Liu, Zhang Mengfan, Qi Chenze, Yang Zhen. Synthetic Studies toward Natural Occurred Cyanolide A and Cocosolide[J]. Chinese Journal of Organic Chemistry, ;2019, 39(11): 3105-3113. doi: 10.6023/cjoc201904071 shu

Synthetic Studies toward Natural Occurred Cyanolide A and Cocosolide

Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, Zhejiang 312000

Corresponding author: Yang Zhen, yangzhen09@usx.edu.cn
Received Date: 29 April 2019
Revised Date: 17 June 2019
Available Online: 9 November 2019
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21302129) and the Natural Science Foundation of Zhejiang Province (No. LQ13B020002)the National Natural Science Foundation of China 21302129the Natural Science Foundation of Zhejiang Province LQ13B020002

Figures(14)

Cyanolide A and cocosolide, two 16-membered dimeric macrolide xylopyranosides, were isolated from Guam and Papua New Guinea, respectively. Their fascinating structures and outstanding biological activities had attracted great attentions from chemists. The synthesis of cyanolide A and cocosolide is reviewed based on the construction methods of tetrahydropyran ring, which involves oxo-Michael addition reaction, oxo-carbenium cyclization and transition-metal catalyzed cyclization reactions.
- cyanolide A,
- cocosolide,
- total synthesis,
- oxo-Michael addition,
- oxo-carbenium cyclization reaction,
- transition-metal catalyzed cyclization reaction
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