Citation: Sun Mao, Qiu Fayang, Li Wei-Dong. Recent Progresses in the Synthesis of Solanoeclepin A[J]. Chinese Journal of Organic Chemistry, ;2019, 39(10): 2759-2770. doi: 10.6023/cjoc201904055 shu

Recent Progresses in the Synthesis of Solanoeclepin A

Sun Mao ^a ,
Qiu Fayang ^d,, ,
Li Wei-Dong ^b,c,,

a.
Pharmaceutical Laboratory, An Shun City People's Hospital, Anshun 561000
b.
Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331
c.
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031
d.
Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530

Corresponding author: Qiu Fayang, qiu_fayang@gibh.ac.cn Li Wei-Dong, wdli@cqu.edu.cn
Received Date: 23 April 2019
Revised Date: 13 May 2019
Available Online: 3 October 2019
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21672030)the National Natural Science Foundation of China 21672030

Figures(25)

Solanoeclepin A, first isolated from potato roots (Solanaceae Juss.) by Mulder et al., is an highly active hatching stimulant (0.3 g per hectare) of potato cyst nematode (PCN, Globodera rostochiensis and G. pallida) which causes severe damage to potato crops. Its complex chemical structure belongs to a rearranged tetranortriterpene and possesses extremely unique skeleton. Based on the known general biosynthesis of tetranortriterpenoids and Prof. Corey's biomimetic synthesis of glycinoeclepin, a plausible biosynthetic pathway of solanoeclepin A is proposed. A schematic review on the synthetic studies towards solanoeclepin A is provided.
- solanoeclepin A,
- tetranortriterpene,
- natural product,
- total synthesis
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