Citation: Liang Jie, Ma Huifang, Ablajan Keyume. High-Selective One-Pot Synthesis of Spirocyclopropane Pyrazolones Promoted by 4-Dimethylaminopyridine[J]. Chinese Journal of Organic Chemistry, ;2019, 39(11): 3169-3175. doi: 10.6023/cjoc201904028 shu

High-Selective One-Pot Synthesis of Spirocyclopropane Pyrazolones Promoted by 4-Dimethylaminopyridine

Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education & Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046

Corresponding author: Ablajan Keyume, ablajan209@hotmail.com
Received Date: 10 April 2019
Revised Date: 11 June 2019
Available Online: 9 November 2019
Fund Project: the National Natural Science Foundation of Chin 21462041the National Natural Science Foundation of Chin 21961038Project supported by the National Natural Science Foundation of China (Nos. 21961038, 21462041)

Figures(4)

A 4-dimethylaminopyridine (DMAP)-promoted high stereoselectivity method for the synthesis of polysubstituted spiropropane pyrazolone was developed. A series of target compounds were synthesized from using pyrazolone, aromatic aldehyde and bromoacetate as raw materials, and DMAP as a base with high yield via three-component one-pot reaction. This reaction has the advantages of simple operation, high yield and good diastereotopic selectivity. In addition, this synthetic method is of great value for the study of spiropropane.
- one-pot synthesis,
- multicomponent reactions,
- spirocyclopropane,
- pyrazolones,
- 4-dimethylaminopyridine (DMAP)
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