Citation: Fan Naili, Xu Zhaohui, Xiang Zhengbing, Xiao Qiang, Liao Chuanwen. Efficent Synthesis of 5-(1-Phenyl-3-phenylprop-2-ynyl)-2, 2-pentylidene-1, 3-dioxane-4, 6-dione Derivatives[J]. Chinese Journal of Organic Chemistry, ;2019, 39(10): 2892-2897. doi: 10.6023/cjoc201903049 shu

Efficent Synthesis of 5-(1-Phenyl-3-phenylprop-2-ynyl)-2, 2-pentylidene-1, 3-dioxane-4, 6-dione Derivatives

a.
Department of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330027
b.
Department of General Surgery, Jiangxi Province People's Hospital, Nanchang 330006

Corresponding author: Xu Zhaohui, gotoxzh@163.com Liao Chuanwen, jxnclcw@163.com
Received Date: 24 March 2019
Revised Date: 30 April 2019
Available Online: 28 October 2019
Fund Project: Project supported by the Graduate Innovation Foundation of Jiangxi Province (No. YC2015-B023) and the Science and Technology Research Project of Jiangxi Provincial Education Department (No. GJJ170170)the Science and Technology Research Project of Jiangxi Provincial Education Department GJJ170170the Graduate Innovation Foundation of Jiangxi Province YC2015-B023

Figures(3)

A convenient and efficient approach for the synthesis of 5-(1-phenyl-3-phenylprop-2-ynyl)-2, 2-pentylidene-1, 3-dioxane-4, 6-dione derivatives through a three-component reaction of aldehydes with 2, 2-pentylidene-1, 3-dioxane-4, 6-dione and arylacetylene in the presence of Cu(OAc)₂·H₂O/Cu is described with 12 examples. The reaction tolerates a wide range of aldehydes furnishing the products with good to excellent isolated yields (65%~88%). Additionally, the synthetic protocol has the advantages of wild conditions, simple operation, and excessive copper reused.
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