Citation: Zhang Xiaopeng, Zhu Yanjie, Zhu Yisong, Li Zhengwei, Zhang Guisheng. Advances in Synthesis of 2, 3-Dihydroquinazolin-4(1H)-ones[J]. Chinese Journal of Organic Chemistry, ;2019, 39(9): 2392-2402. doi: 10.6023/cjoc201903025 shu

Advances in Synthesis of 2, 3-Dihydroquinazolin-4(1H)-ones

Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007

Corresponding author: Zhang Xiaopeng, zhangxiaopengv@sina.com
Received Date: 14 March 2019
Revised Date: 11 April 2019
Available Online: 26 September 2019
Fund Project: the National Natural Science Foundation of China U1604285the National Natural Science Foundation of China 21772033the National Natural Science Foundation of China (Nos. 21772033, U1604285) and the Program of Introducing Talents of Discipline to Universities (111 Project, No. D17007)the Program of Introducing Talents of Discipline to Universities 111 Project, No. D17007

Figures(19)

2, 3-Dihydroquinazolin-4(1H)-one compounds are an important class of nitrogen-containing fused heterocycles, which possess a wide range of pharmacological and biological activities and have important applications in the fields of synthesis and research & development of drugs. Therefore, its synthetic methods have also attracted considerable attention. In this paper, the main advances in the synthesis of 2, 3-dihydroquinazolin-4(1H)-ones and their proposed reaction mechanisms from the raw materials such as o-aminobenzamides, isatoic anhydrides, o-nitrobenzamides, o-azidobenzamide, o-bromo-benzamide, o-bromobenzonitrile, o-aminobenzoic acids, o-aminobenzonitrile, o-amino-N-(propa-1, 2-dienyl)benzamides, and N-alkyl anilines were introduced and reviewed, respectively. Finally, the synthesis of these compounds was summarized and the prospect of their development was prospected.
- 2, 3-dihydroquinazolin-4(1H)-one,
- o-aminobenzamides,
- isatoic anhydrides,
- N-alkyl anilines,
- C-H activation & functionalization,
- palladium catalysis
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