Citation: Xie Tinghui, Jiang Xiaoying, Mi Zhisheng, Li Xue, Xu Xiaohe, Bai Renren, Shuai Qi, Xie Yuanyuan. Iron/O₂-Promoted C-H Bond Functionalization for the Exclusive Synthesis of 2-Quinoline Carboxaldehydes under Microwave Irradiation[J]. Chinese Journal of Organic Chemistry, ;2019, 39(11): 3294-3298. doi: 10.6023/cjoc201903007 shu

Iron/O₂-Promoted C-H Bond Functionalization for the Exclusive Synthesis of 2-Quinoline Carboxaldehydes under Microwave Irradiation

Xie Tinghui ^a,b ,
Jiang Xiaoying ^a ,
Mi Zhisheng ^a ,
Li Xue ^a ,
Xu Xiaohe ^a ,
Bai Renren ^a ,
Shuai Qi ^a ,
Xie Yuanyuan ^a,,

a.
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceutical, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014
b.
College of Agriculture and Bioengineering, Taizhou Vocational College of Science and Technology, Taizhou, Zhejiang 318020

Corresponding author: Xie Yuanyuan, xyycz@zjut.edu.cn
Received Date: 4 March 2019
Revised Date: 25 April 2019
Available Online: 9 November 2019
Fund Project: the National Natural Science Foundation of China 20150281Project supported by the National Natural Science Foundation of China (No. 21576239)

Figures(4)

An one-pot iron-catalyzed oxidative formylation of 2-methylquinolines to produce 2-quinoline carboxaldehydes under microwave irradiation has been achieved by employing O₂ as the oxygen donor. The reaction was general for the substrates with a wide range of functional groups, providing a yield of 48%~80%. The preliminary mechanistic studies revealed that the reaction underwent a radical pathway. Advantages of this method include the easy operation, short reaction time and good selectivity.
- 2-quinoline carboxaldehydes,
- iron catalysis,
- C-H oxidation,
- microwave irradiation
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Iron/O2-Promoted C-H Bond Functionalization for the Exclusive Synthesis of 2-Quinoline Carboxaldehydes under Microwave Irradiation

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通讯作者: 陈斌, bchen63@163.com

Iron/O₂-Promoted C-H Bond Functionalization for the Exclusive Synthesis of 2-Quinoline Carboxaldehydes under Microwave Irradiation