Citation: Shang Fanfan, Jin Lan, Zhang Haibin, Piao Lianxun, Quan Zheshan. Synthesis and Anti-toxoplasma Activity in Vitro of Chrysin Derivatives[J]. Chinese Journal of Organic Chemistry, ;2019, 39(9): 2574-2580. doi: 10.6023/cjoc201901016 shu

Synthesis and Anti-toxoplasma Activity in Vitro of Chrysin Derivatives

College of Pharmacy, Yanbian University, Yanji 133002

Corresponding author: Piao Lianxun, lxpiao@ybu.edu.cn Quan Zheshan, zsquan@ybu.edu.cn
Received Date: 11 January 2019
Revised Date: 28 February 2019
Available Online: 21 September 2019
Fund Project: the National Natural Science Foundation of China 21662036the National Natural Science Foundation of China 81660344Project supported by the National Natural Science Foundation of China (Nos. 21662036, 81660344)

Figures(2)

In this paper, 18 novel chrysin derivatives were designed and synthesized. All target compounds were tested for anti-Toxoplasma activity by methyl thiazolyl tetrazolium (MTT) colorimetric method. The chemical structures were characterized by ¹H NMR, ¹³C NMR and HRMS spectra. The selectivity index of 5-hydroxy-7-methoxy-4-oxo-N, 2-diphenyl-4H-chro-mene-8-sulfonamide (D2) was 1.76, indicating that the anti-toxoplasma activity of compound D2 was significantly higher than that of the lead compound chrysin and the positive control drug sulfadiazine.
- chrysin derivatives,
- synthesis,
- toxoplasma activity,
- in vitro,
- selectivity index
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沈阳化工大学材料科学与工程学院沈阳 110142