Citation: Xu Wentao, Wang Ning, Zhang Mengye, Shi Daqing. Ruthenium-Catalyzed C(sp²)-H Alkenylation and Alkylation of 1-Benzyl-1H-pyrazole under Assistance of Pyrazole Group[J]. Chinese Journal of Organic Chemistry, ;2019, 39(6): 1735-1742. doi: 10.6023/cjoc201901005 shu

Ruthenium-Catalyzed C(sp²)-H Alkenylation and Alkylation of 1-Benzyl-1H-pyrazole under Assistance of Pyrazole Group

College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123

Corresponding author: Shi Daqing, dqshi@suda.edu.cn
Received Date: 5 January 2019
Revised Date: 27 February 2019
Available Online: 21 June 2019
Fund Project: the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions 15KJA150006Project supported by the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions (No. 15KJA150006)

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A practical ruthenium-catalyzed C(sp²)-H alkenylation and alkylation of 1-benzyl-1H-pyrazole with alkene or a, β-unsaturated ketones under the assistance of pyrazole group were developed. This method has the advantages of high selectivity, providing only the ortho-alkenylation or ortho-alkylation products in high yields. This protocol provides an efficient and new method for the functionalization of 1-benzyl-1H-pyrazoles.
- 1-benzyl-1H-pyrazole,
- alkenylation,
- alkylation,
- C(sp²)-H bond
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沈阳化工大学材料科学与工程学院沈阳 110142

Ruthenium-Catalyzed C(sp2)-H Alkenylation and Alkylation of 1-Benzyl-1H-pyrazole under Assistance of Pyrazole Group

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通讯作者: 陈斌, bchen63@163.com

Ruthenium-Catalyzed C(sp²)-H Alkenylation and Alkylation of 1-Benzyl-1H-pyrazole under Assistance of Pyrazole Group