Citation: Yan Shiqiang, Guo Wei, Wang Wensheng, Zhang Wei. Zinc-Proline Complex Catalyzed Knoevenagel Condensation in Water[J]. Chinese Journal of Organic Chemistry, ;2019, 39(5): 1469-1474. doi: 10.6023/cjoc201812046 shu

Zinc-Proline Complex Catalyzed Knoevenagel Condensation in Water

Yan Shiqiang ^a,b ,
Guo Wei ^b ,
Wang Wensheng ^b ,
Zhang Wei ^a,,

a.
School of Pharmacy, Fudan University, Shanghai 201203
b.
Shandong Dyne Marine Biopharmaceutical Co., Ltd., Weihai 264300

Corresponding author: Zhang Wei, zhangw416@fudan.edu.cn
Received Date: 26 December 2018
Revised Date: 16 January 2019
Available Online: 31 May 2019
Fund Project: the Special Projects for Independent Innovation and Achievement Transformation of Shandong Province 2015ZDXX0302A02the National Natural Science Foundation of China 81573340Project supported by the National Natural Science Foundation of China (No. 81573340) and the Special Projects for Independent Innovation and Achievement Transformation of Shandong Province (No. 2015ZDXX0302A02)

Figures(2)

Zinc-proline complex catalyzed Knoevenagel condensation in water was reported. Seventeen aldehydes and two ketones were investigated, which coupled with malononitrile smoothly affording desired Knoevenagel condensation products in 5~10 min at 80℃ in the yields of 84%~99%. The catalyst can be recovered and reused for ten cycles without loss of activity.
- Knoevenagel condensation,
- aqueous media,
- zinc-proline complex,
- environmentally benign
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