Citation: Xu Huanji, Li Zheming, Wu Yunqiu, Luo Di, Qiu Li, Xie Jizhao, Li Xuehua. Advances on Synthesis of Flavonoid Glycosides[J]. Chinese Journal of Organic Chemistry, ;2019, 39(7): 1875-1890. doi: 10.6023/cjoc201811002 shu

Advances on Synthesis of Flavonoid Glycosides

Xu Huanji ^a ,
Li Zheming ^a ,
Wu Yunqiu ^a ,
Luo Di ^a ,
Qiu Li ^a ,
Xie Jizhao ^a,b,, ,
Li Xuehua ^a,,

a.
School of Pharmacy, Guangxi Medical University, Nanning 530021
b.
School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004

Corresponding author: Xie Jizhao, xiejizhao@gxmu.edu.cn Li Xuehua, onlythankforyou@163.com
Received Date: 1 November 2018
Revised Date: 23 January 2019
Available Online: 19 July 2019
Fund Project: the National Natural Science Foundation of China 21662005Project supported by the National Natural Science Foundation of China (No. 21662005)

Figures(14)

Flavonoid glycoside is commonly found in natural plants, possesses diverse bioactivities and potential medicinal values, and its synthesis methods are worthy to be studied. The synthesis of flavonoid glycosides covering the literatures from 2014 to 2018 is reviewed. The flavonoid glycoside synthesis includes two major methods of chemosynthesis and biosynthesis. Chemosynthesis includes total synthesis and semi-synthesis. The total synthesis has two classical methods of the Baker- Venkataraman (BK-VK) reaction and the Algar-Flynn-Oyamada (AFO) reaction. The semi-synthesis is usually starting from natural flavonoid, such as rutin, quercetin, kaempferol, naringenin and so on. Moreover, the chemosynthesis of flavonoid O-glucoside has three prime methods, Koening-Knorr method, phase transfer catalysis method, and glycosyl trichloroacetimidate method. As for the chemosynthesis of flavonoid C-glycoside, its glycosidic linkage is mainly completed via the O→C rearrangement reaction. Currently, the glycosyltransferase and glycosynthase are usually employed in the enzyme-catalyzed biosynthesis of flavonoid glycosides.
- flavonoid glycosides,
- synthesis,
- flavonoid aglycones,
- condensation of glycosides,
- review
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