Citation: Wu Wensheng, Yuan Hang, Huang Gaokui, Jiang Chunhui, Lu Hongfei. Fluorination of β-Ketoesters and β-Ketoamides Based on PhI(OAc)₂[J]. Chinese Journal of Organic Chemistry, ;2019, 39(1): 137-143. doi: 10.6023/cjoc201808047 shu

Fluorination of β-Ketoesters and β-Ketoamides Based on PhI(OAc)₂

School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003

Corresponding author: Jiang Chunhui, chemjiang@just.edu.cn Lu Hongfei, zjluhf1979@just.edu.cn

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Received Date: 31 August 2018
Revised Date: 25 October 2018
Available Online: 5 January 2018
Fund Project: the Natural Science Fund for Colleges and Universities in Jiangsu Province 17KJB150013Project supported by the National Natural Science Foundation of China (No. 21402067), the Natural Science Foundation of Jiangsu Province (No. BK20170569) and the Natural Science Fund for Colleges and Universities in Jiangsu Province (No. 17KJB150013)the National Natural Science Foundation of China 21402067the Natural Science Foundation of Jiangsu Province BK20170569

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Herein, a nucleophilic fluorination reaction to construct fluorine-containing β-ketoesters and β-ketoamides is reported. The reaction uses PhI(OAc)₂ as oxidant and 3HF·Et₃N as fluorinating reagent. It can effectively build a series of fluorochemical compounds containing quaternary carbon center under room temperature reaction conditions for 30 min. Compared with the traditional electrophilic fluorination reaction, this method has the advantages of no metal participation, short reaction time, simple reaction conditions and high reaction yield.
- hypervalent iodine,
- β-ketoesters,
- β-ketoamides,
- nucleophilic fluorination reaction
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Fluorination of β-Ketoesters and β-Ketoamides Based on PhI(OAc)2

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Fluorination of β-Ketoesters and β-Ketoamides Based on PhI(OAc)₂