Citation: Zhang Jieyu, Ke Qiumin, Chen Jiaying, He Ping, Yan Guobing. Recent Progress in the Synthesis of Aryl Trifluoromethyl Ketones[J]. Chinese Journal of Organic Chemistry, ;2019, 39(1): 74-83. doi: 10.6023/cjoc201808046 shu

Recent Progress in the Synthesis of Aryl Trifluoromethyl Ketones

Department of Chemistry, Lishui University, Lishui 323000

Corresponding author: He Ping, Yan Guobing, gbyan@lsu.edu.cn
Received Date: 31 August 2018
Revised Date: 16 October 2018
Available Online: 26 January 2018
Fund Project: the Natural Science Foundation of Zhejiang Province LY18B020005Project supported by the Natural Science Foundation of Zhejiang Province (No. LY18B020005)

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Aryl trifluoromethyl ketone is a very important intermediate in the organic synthesis. Much attention has been attracted from researchers, due to its potential bioactivity. In this paper, the recent progress in the synthesis of aryl trifluoromethyl ketone is reviewed, including the oxidant of α-trifluoromethyl alcohols, trifluoromethylation of carboxylic acid derivatives, trifluoroacetylation of organometallic reagents, electron-rich aromatics, aryl halides and aryl diazonium salts, and the reaction mechanisms are also discussed.
- aryl trifluoromethyl ketones,
- trifluoroacetylation,
- coupling reaction,
- reaction mechanism
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