Citation: Gao Yaohui, Wang Gaoqian, Huang Huiyun, Gao Hao, Yao Xinsheng, Hu Dan. Biosynthesis of Fungal Triterpenoids and Steroids[J]. Chinese Journal of Organic Chemistry, ;2018, 38(9): 2335-2347. doi: 10.6023/cjoc201806033 shu

Biosynthesis of Fungal Triterpenoids and Steroids

Institute of Traditional Chinese Medicine and Natural Products, School of Pharmacy, Jinan University, Guangzhou 510632

Corresponding author: Hu Dan, thudan@jnu.edu.cn
Received Date: 20 June 2018
Revised Date: 6 July 2018
Available Online: 16 September 2018
Fund Project: Project supported by the National Natural Science Foundation of China (No. 31670036)the National Natural Science Foundation of China 31670036

Figures(12)

Triterpenoids and steroids are one of the largest classes of natural products composed of six isoprene units, with various chemical structures as well as wide range of biological activities. Fungi serves as important sources for triterpenoids and steroids. However, compared with plants, the types of triterpenoid skeletons discovered in fungi are much fewer, suggesting that there is a large research space. Genome mining has become an important method of discovering novel natural products in the post-genomic era, which uses the genes with similar functional to identify the target genes with new functions. With the rapid development of high-throughput sequencing and biological information technology, biosynthetic pathways of some triterpenoids and steroids with important biological activities have been elucidated in recent years, which build the foundations for the discovery of new triterpenoids or steroids from fungi via genome mining. The recent advances in the biosynthesis of fungal triterpenoids and steroids are mainly introduced.
- triterpenoids,
- steroids,
- fungi,
- biosynthesis,
- genome mining
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