Citation: Shi Yujun, Zhou Qian, Wang Yang, Qian Hongwei, Ye Linyu, Feng Xia, Chen Hui, Li Yating, Dai Hong, Wei Zhonghao, Wu Jinming. Synthesis and Biological Activities of Novel Pyrazole Amide Derivatives Containing Substituted Pyridyl Group[J]. Chinese Journal of Organic Chemistry, ;2018, 38(9): 2450-2457. doi: 10.6023/cjoc201806030 shu

Synthesis and Biological Activities of Novel Pyrazole Amide Derivatives Containing Substituted Pyridyl Group

Shi Yujun ^a ,
Zhou Qian ^a ,
Wang Yang ^a ,
Qian Hongwei ^a ,
Ye Linyu ^a ,
Feng Xia ^a ,
Chen Hui ^b ,
Li Yating ^a ,
Dai Hong ^b,a,, ,
Wei Zhonghao ^a ,
Wu Jinming ^a,,

a.
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019
b.
Xinglin College, Nantong University, Nantong 226008

Corresponding author: Dai Hong, daihong_2015@aliyun.com Wu Jinming, ntgao2016@163.com
Received Date: 20 June 2018
Revised Date: 19 July 2018
Available Online: 14 September 2018
Fund Project: the Research Foundation of the Six People Peak of Jiangsu Province 2013-SWYY-013the Science and Technology Innovation Foundation for the College Students of Jiangsu Province 201810304016Zthe Science Foudation of Nantong University Xinglin College 2016K130the Science and Technology Project Fund of Nantong City MS22015020the National Natural Science Foundation of China 21372135Project supported by the National Natural Science Foundation of China (No. 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No. 2013-SWYY-013), the Science and Technology Project Fund of Nantong City (No. MS22015020), the Science and Technology Innovation Foundation for the College Students of Jiangsu Province (No. 201810304016Z) and the Science Foudation of Nantong University Xinglin College (No. 2016K130)

Figures(3)

In order to find novel pyrazole amides having potent bioactivities, a series of novel pyrazole amide compounds carrying substituted pyridyl moiety were designed and synthesized according to the method of active substructure combination. The preliminary bioassay data showed that some title compounds displayed good insecticidal activities. At the concentration of 500 μg/mL, ten compounds exhibited insecticidal activity against Oriental armyworm with 60%~100%, and one compound indicated insecticidal activity against Aphis medicaginis with 100%. When the concentration was reduced to 100 μg/mL, two compounds still showed insecticidal activity against Oriental armyworm with 70%~100%, which were better than that of the control tolfenpyrad. Additionally, one compound displayed 50% insecticidal activity against Oriental armyworm at the concentration of 20 μg/mL.
- pyridine,
- pyrazole amide,
- synthesis,
- bioactivity
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