Citation: Ni Guowei, Tang Jiawei, Zou Jie, Chen Shaoxin, Ju Dianwen, Zhang Fuli. Recent Advances on Carbonyl Reductases for Dynamic Kinetic Resolution[J]. Chinese Journal of Organic Chemistry, ;2019, 39(2): 339-349. doi: 10.6023/cjoc201806012 shu

Recent Advances on Carbonyl Reductases for Dynamic Kinetic Resolution

Ni Guowei ^a,b ,
Tang Jiawei ^a ,
Zou Jie ^a ,
Chen Shaoxin ^a ,
Ju Dianwen ^b,, ,
Zhang Fuli ^a,,

a.
State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203
b.
School of Pharmacy, Fudan University, Shanghai 201203

Corresponding author: Ju Dianwen, dianwenju@fudan.edu.cn Zhang Fuli, zhangfuli1@sinopharm.com
Received Date: 7 June 2018
Revised Date: 7 August 2018
Available Online: 10 February 2018

Figures(18)

Biocatalysis is a basic method of asymmetric catalysis for preparing chiral Active Pharmaceutical Ingredients, which owns several "green merits":chemo-, regio-and high enantioselectivity. As the development of DNA seqencing, DNA synthesis and protein engineering, suitable enzymes can be efficiently developed for basic researches and industrial applications. Biocatalysis has been keeping as a hot spot in asymmetric synthesis recently. Carbonyl reductases have been widely used for stereoselectively transforming ketones to chiral second alcohols with only one stereocenter. When combining with Dynamic Kinetic Resolution (DKR), the bioreaction with carbonyl reductases can efficiently construct chiral alcohols with two stereocenters in one step. This review highlights the method of its mechanism and nearly twenty examples from research papers and patents for one decade. We attempt to analyze and conclude the characteristics of this method based on chemical structures and enzymes. At last, a practical and developing research method is recommended in three steps:screening-racemization-balance in sequence. It is hoped to be useful for future basic researches and industrial applications.
- asymmetric catalysis,
- biocatalysis,
- carbonyl reductases,
- dynamic kinetic resolution
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