Citation: Wang Pingping, Yang Chengshuai, Li Xiaodong, Jiang Yuguo, Yan Xing, Zhou Zhihua. Route to Artificially Synthesize Plant Natural Products[J]. Chinese Journal of Organic Chemistry, ;2018, 38(9): 2199-2214. doi: 10.6023/cjoc201805060 shu

Route to Artificially Synthesize Plant Natural Products

Wang Pingping ^a ,
Yang Chengshuai ^a,b ,
Li Xiaodong ^a,b ,
Jiang Yuguo ^a,b ,
Yan Xing ^a ,
Zhou Zhihua ^a,,

a.
CAS-Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032
b.
University of Chinese Academy of Sciences, Beijing 100049

Corresponding author: Zhou Zhihua, zhouzhihua@sippe.ac.cn
Received Date: 31 May 2018
Revised Date: 30 July 2018
Available Online: 23 September 2018
Fund Project: the Key Deployment Projects of the Chinese Academy of Sciences Nos.KFZD-SW-215the International Great Science Program of the Chinese Academy of Sciences 153D31KYSB20170121the "Strategic Priority Research Program" of the Chinese Academy of Sciences XDPB0400the National Natural Science Foundation of China 21672228Project supported by the National Natural Science Foundation of China (No. 21672228), the Key Deployment Projects of the Chinese Academy of Sciences (Nos. KFZD-SW-215), the "Strategic Priority Research Program" of the Chinese Academy of Sciences (No. XDPB0400) and the International Great Science Program of the Chinese Academy of Sciences (No. 153D31KYSB20170121)

Figures(7)

Plant natural products and their derivatives are the important reservoirs for the development of medicines, health products and food additives. The synthetic biology technology brings new strategies to manufacture rare plant natural products with complicated structures at large scale by artificially constructing and optimizing the biosynthesis pathway of target compounds in microbial chassis cells. In this paper, the research progress on the artificial syntheses of important plant natural products such as artemisinin, ginsenosides, morphinan alkaloids, paclitaxel and vinblastine is reviewed. These examples not only demonstrate the great potentials of synthetic biology as well as its combination with synthetic chemistry applied in the artificial syntheses of plant natural compounds, but also show us the roadmap for future research and development on de novo synthesis of plant natural products. New technologies developed in synthetic biology and synthetic chemistry would further promote the unveiling of biosynthetic pathways of complex natural compounds, the discovery and characterization of key bioparts, the design and building of novel chassis cells, the strong-strong combination of biosynthesis and chemical synthesis, and thus accelerate the process to transfer the developed technologies to artificially synthesize plant natural products from laboratories to markets.
- synthetic biology,
- synthetic chemistry,
- de novo synthesis,
- biosynthetic pathway,
- biopart,
- chassis cell,
- genomic editing
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沈阳化工大学材料科学与工程学院沈阳 110142