Citation: Wang Zhipeng, Li Man, Li Hui, Liu Zhihua, Li Ying, Zheng Ji-Shen. Chemical (Semi-) Synthesis and Applications of Lysine Post-Translationally Modified Proteins[J]. Chinese Journal of Organic Chemistry, ;2018, 38(9): 2400-2411. doi: 10.6023/cjoc201804046 shu

Chemical (Semi-) Synthesis and Applications of Lysine Post-Translationally Modified Proteins

Wang Zhipeng ^a,b,, ,
Li Man ^c ,
Li Hui ^d ,
Liu Zhihua ^c ,
Li Ying ^a ,
Zheng Ji-Shen ^a,,

a.
School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
b.
Department of Chemistry, Texas A & M University, Texas 77840, USA
c.
Department of Plant Pathology and Microbiology, Texas A & M University, Texas 77843, USA
d.
Anhui Supervision of Veterinay Drug and Feed, Hefei 230091, China

Corresponding author: Wang Zhipeng, hipeng.wang@chem.tamu.edu Zheng Ji-Shen, jszheng@ustc.edu.cn
Received Date: 28 April 2018
Revised Date: 19 May 2018
Available Online: 7 September 2018
Fund Project: Project supported by the National Natural Science Foundation of China (No. U1732161), the Science and Technological Fund of Anhui Province for Outstanding Youth (No. 1808085J04) and the Innovative Program Development Foundation of Hefei Center Physical Science and Technology (No. 2017FXCX002)the National Natural Science Foundation of China U1732161the Innovative Program Development Foundation of Hefei Center Physical Science and Technology 2017FXCX002the Science and Technological Fund of Anhui Province for Outstanding Youth 1808085J04

Figures(9)

The study of native proteins with post-translational modifications (PTMs) is one of the main fields of epigenetics. The discovery of novel PTM models and their vital regulatory role for chromatin structure and gene transcription have been one of the current research focuses drawing attention of biologists especially in recent years. However, we still lack efficient strategies for the preparation of sufficient amount of native proteins with certain PTMs. The currently existing chemical biology methods are reviewed, and their advantages and disadvantages are compared, including bioorthogonal reaction technique, non-canonical amino acid incorporation, etc. Furthermore, the draft will mainly focus on the application of bioorthogonal reactions on unnatural functional groups for the incorporation of lysine PTMs.
- chemical synthesis of proteins,
- post-translational modifications,
- non-canonical amino acid,
- bioorthogonal reaction,
- proteome
1. [1]
  Kouzarides, T. Cell 2007, 128, 693. doi: 10.1016/j.cell.2007.02.005
2. [2]
  Li, Y.; Barløse, C.; Jørgensen, J.; Carlsen, B. D. Jørgensen, K. A. Chem.-Eur. J. 2017, 23, 38. doi: 10.1002/chem.201604310
3. [3]
  Dann, G. P.; Liszczak, G. P.; Bagert, J. D.; Müller, M. M.; Nguyen, U. T.; Wojcik, F.; Brown, Z. Z.; Bos, J.; Panchenko, T.; Pihl, R.; Muir, T. W. Nature 2017, 548, 607. doi: 10.1038/nature23671
4. [4]
  Latham, J. A.; Dent, S. Y. Nat. Struct. Mol. Biol. 2007, 14, 1017. doi: 10.1038/nsmb1307
5. [5]
  Hamamoto, R.; Saloura, V.; Nakamura, Y. Nat. Rev. Cancer 2015, 15, 110. doi: 10.1038/nrc3884
6. [6]
  Greer, E. L.; Shi, Y. Nat. Rev. Genet. 2012, 13, 343.
7. [7]
  Wang, Z. A.; Cheng, N. Y.; Liang, Y. Y.; Ma, X. Y. Univ. Chem. 2017, 32, 41(in Chinese).
8. [8]
  Chuikov, S.; Kurash, J. K.; Wilson, J. R.; Xiao, B.; Justin, N.; Ivanov, G. S.; McKinney, K.; Tempst, P.; Prives, C.; Gamblin, S. J. Nature 2004, 432, 353. doi: 10.1038/nature03117
9. [9]
  He, Q.; Li, J.; Qi, Y.; Wang, Z.; Huang, Y.; Liu, L. Sci. China Chem. 2017, 60, 621. doi: 10.1007/s11426-016-0386-4
10. [10]
  Xie, Z.; Dai, J.; Dai, L.; Tan, M.; Cheng, Z.; Wu, Y.; Boeke, J. D.; Zhao, Y. Mol. Cell. Proteomics 2012, 11, 100. doi: 10.1074/mcp.M111.015875
11. [11]
  Weinert, B. T.; Schölz, C.; Wagner, S. A.; Iesmantavicius, V.; Su, D.; Daniel, J. A.; Choudhary, C. Cell Rep. 2013, 4, 842. doi: 10.1016/j.celrep.2013.07.024
12. [12]
  Guan, C. J.; Wang, T.; Wang, J.; Yi, Y.-M. Chin. J. Org. Chem. 2016, 36, 2763(in Chinese).
13. [13]
  Wang, Z.-P.; Wang, Y.-H.; Chu, G.-C.; Shi, J.; Li, Y.-M. Curr. Org. Synth. 2015, 12, 150. doi: 10.2174/1570179411666141125215343
14. [14]
  Chen, B.; Zang, W.; Wang, J.; Huang, Y.; He, Y.; Yan, L.; Liu, J.; Zheng, W. Chem. Soc. Rev. 2015, 44, 5246. doi: 10.1039/C4CS00373J
15. [15]
  Luo, J.; Li, M.; Tang, Y.; Laszkowska, M.; Roeder, R. G.; Gu, W. Proc. Natl. Acad. Sci. U. S. A. 2004, 101,
16. [16]
  Martino, F.; Kueng, S.; Robinson, P.; Tsai-Pflugfelder, M.; van Leeuwen, F.; Ziegler, M.; Cubizolles, F.; Cockell, M. M.; Rhodes, D.; Gasser, S. M. Mol. Cell 2009, 33, 323. doi: 10.1016/j.molcel.2009.01.009
17. [17]
  Li, Y. M.; Li, Y. T.; Pan, M.; Kong, X. Q.; Huang, Y. C.; Hong, Z. Y.; Liu, L. Angew. Chem., Int. Ed. 2014, 53, 2198. doi: 10.1002/anie.201310010
18. [18]
  Tang, Y.; Zhao, W.; Chen, Y.; Zhao, Y.; Gu, W. Cell 2008, 133, 612. doi: 10.1016/j.cell.2008.03.025
19. [19]
  Li, F.; Zhang, H.; Sun, Y.; Pan, Y.; Zhou, J.; Wang, J. Angew. Chem., Int. Ed. 2013, 52, 9700. doi: 10.1002/anie.201303477
20. [20]
  Zhang, G.; Zheng, S.; Liu, H.; Chen, P. R. Chem. Soc. Rev. 2015, 44, 3405. doi: 10.1039/C4CS00393D
21. [21]
  Chalker, J. M.; Bernardes, G. a. J.; Davis, B. G. Acc. Chem. Res. 2011, 44, 730. doi: 10.1021/ar200056q
22. [22]
  Chen, J.; Fu, H.; Chen, Y.; Zhao, Y. F. Chin. J. Org. Chem. 2002, 22, 81(in Chinese). doi: 10.3321/j.issn:0253-2786.2002.02.001
23. [23]
  Chatterjee, C.; McGinty, R. K.; Fierz, B.; Muir, T. W. Nat. Chem. Biol. 2010, 6, 267. doi: 10.1038/nchembio.315
24. [24]
  Fang, G. M.; Li, Y. M.; Shen, F.; Huang, Y. C.; Li, J. B.; Lin, Y.; Cui, H. K.; Liu, L. Angew. Chem., Int. Ed. 2011, 50, 7645. doi: 10.1002/anie.201100996
25. [25]
  Zheng, J.-S.; Tang, S.; Qi, Y.-K.; Wang, Z.-P.; Liu, L. Nat. Protoc. 2013, 8, 2483. doi: 10.1038/nprot.2013.152
26. [26]
  Zheng, J.-S.; Yu, M.; Qi, Y.-K.; Tang, S.; Shen, F.; Wang, Z.-P.; Xiao, L.; Zhang, L.; Tian, C.-L.; Liu, L. J. Am. Chem. Soc. 2014, 136, 3695. doi: 10.1021/ja500222u
27. [27]
  Tang, S.; Si, Y. Y.; Wang, Z. P.; Mei, K. R.; Chen, X.; Cheng, J. Y.; Zheng, J. S.; Liu, L. Angew. Chem., Int. Ed. 2015, 127, 5805. doi: 10.1002/ange.201500051
28. [28]
  Fang, G. M.; Wang, J. X.; Liu, L. Angew. Chem., Int. Ed. 2012, 51, 10347. doi: 10.1002/anie.201203843
29. [29]
  Tang, S.; Liang, L. J.; Si, Y. Y.; Gao, S.; Wang, J. X.; Liang, J.; Mei, Z.; Zheng, J. S.; Liu, L. Angew. Chem., Int. Ed. 2017, 56, 13333. doi: 10.1002/anie.201708067
30. [30]
  Shimko, J. C.; North, J. A.; Bruns, A. N.; Poirier, M. G.; Ottesen, J. J. J. Mol. Boil. 2011, 408, 187. doi: 10.1016/j.jmb.2011.01.003
31. [31]
  Li, J.; Li, Y.; He, Q.; Li, Y.; Li, H.; Liu, L. Org. Biomol. Chem. 2014, 12, 5435. doi: 10.1039/C4OB00715H
32. [32]
  Howard, C. J.; Ruixuan, R. Y.; Gardner, M. L.; Shimko, J. C.; Ottesen, J. J. Top. Curr. Chem. 2015, 363, 193. doi: 10.1007/978-3-319-19189-8
33. [33]
  Zhang, W.; Wang, Y. Q.; Wang, J. Y. Prog. Biochem. Biophys. 2012, 39, 378(in Chinese).
34. [34]
  Wang, L.; Xie, J.; Schultz, P. G. Annu. Rev. Biophys. Biomol. Struct. 2006, 35, 225. doi: 10.1146/annurev.biophys.35.101105.121507
35. [35]
  Dumas, A.; Lercher, L.; Spicer, C. D.; Davis, B. G. Chem. Sci. 2015, 6, 50. doi: 10.1039/C4SC01534G
36. [36]
  Neumann, H.; Hancock, S. M.; Buning, R.; Routh, A.; Chapman, L.; Somers, J.; Owen-Hughes, T.; van Noort, J.; Rhodes, D.; Chin, J. W. Mol. Cell 2009, 36, 153. doi: 10.1016/j.molcel.2009.07.027
37. [37]
  Lee, Y.-J.; Wu, B.; Raymond, J. E.; Zeng, Y.; Fang, X.; Wooley, K. L.; Liu, W. R. ACS Chem. Biol. 2013, 8, 1664. doi: 10.1021/cb400267m
38. [38]
  Kim, C. H.; Kang, M.; Kim, H. J.; Chatterjee, A.; Schultz, P. G. Angew. Chem., Int. Ed. 2012, 51, 7246. doi: 10.1002/anie.201203349
39. [39]
  Thinon, E.; Serwa, R. A.; Broncel, M.; Brannigan, J. A.; Brassat, U.; Wright, M. H.; Heal, W. P.; Wilkinson, A. J.; Mann, D. J.; Tate, E. W. Nat. Commun. 2014, 5, 1.
40. [40]
  Simon, M. D.; Chu, F.; Racki, L. R.; Cecile, C.; Burlingame, A. L.; Panning, B.; Narlikar, G. J.; Shokat, K. M. Cell 2007, 128, 1003. doi: 10.1016/j.cell.2006.12.041
41. [41]
  Li, J.; Chen, P. R. Nat. Chem. Biol. 2016, 12, 129. doi: 10.1038/nchembio.2024
42. [42]
  Nguyen, D. P.; Garcia Alai, M. M.; Kapadnis, P. B.; Neumann, H.; Chin, J. W. J. Am. Chem. Soc. 2009, 131, 14194. doi: 10.1021/ja906603s
43. [43]
  Ai, H. W.; Lee, J. W.; Schultz, P. G. Chem. Commun. 2010, 46, 5506. doi: 10.1039/c0cc00108b
44. [44]
  Wang, Y.-S.; Wu, B.; Wang, Z.; Huang, Y.; Wan, W.; Russell, W. K.; Pai, P.-J.; Moe, Y. N.; Russell, D. H.; Liu, W. R. Mol. BioSyst. 2010, 6, 1557. doi: 10.1039/c002155e
45. [45]
  Gautier, A.; Deiters, A.; Chin, J. W. J. Am. Chem. Soc. 2011, 133, 2124. doi: 10.1021/ja1109979
46. [46]
  Hemphill, J.; Chou, C.; Chin, J. W.; Deiters, A. J. Am. Chem. Soc. 2013, 135, 13433. doi: 10.1021/ja4051026
47. [47]
  Nguyen, D. P.; Alai, M. M. G.; Virdee, S.; Chin, J. W. Chem. Biol. 2010, 17, 1072. doi: 10.1016/j.chembiol.2010.07.013
48. [48]
  Virdee, S.; Ye, Y.; Nguyen, D. P.; Komander, D.; Chin, J. W. Nat. Chem. Biol. 2010, 6, 750. doi: 10.1038/nchembio.426
49. [49]
  Wang, Z. A.; Li, J.; Li, Y. M. Chin. J. Org. Chem. 2013, 33, 1874(in Chinese).
50. [50]
  Li, J. W.; Jie Chen, P. R. Acta Chim. Sinica 2012, 70, 1439(in Chinese). doi: 10.3866/PKU.WHXB201203142
51. [51]
  Bertozzi, C. R. Acc. Chem. Res. 2011, 44, 651. doi: 10.1021/ar200193f
52. [52]
  Yang, M. Y.; Chen, P. R. Acta Chim. Sinica 2015, 73, 783(in Chinese). doi: 10.3866/PKU.WHXB201502062
53. [53]
  Seeliger, D.; Soeroes, S.; Klingberg, R.; Schwarzer, D.; Grubmüller, H.; Fischle, W. ACS Chem. Biol. 2011, 7, 150.
54. [54]
  Yang, A.; Ha, S.; Ahn, J.; Kim, R.; Kim, S.; Lee, Y.; Kim, J.; Söll, D.; Lee, H.-Y.; Park, H.-S. Science 2016, 354, 623. doi: 10.1126/science.aah4428
55. [55]
  Wright, T. H.; Bower, B. J.; Chalker, J. M.; Bernardes, G. J.; Wiewiora, R.; Ng, W.-L.; Raj, R.; Faulkner, S.; Vallée, M. R. J.; Phanumartwiwath, A.; Davis, B. G. Science 2016, 354, 1465. doi: 10.1126/science.aag1465
56. [56]
  Wang, Z. A.; Liu, W. R. Chem. Eur. J. 2017, 23, 11732. doi: 10.1002/chem.201701655
57. [57]
  Prescher, J. A.; Bertozzi, C. R. Nat. Chem. Biol. 2005, 1, 13. doi: 10.1038/nchembio0605-13
58. [58]
  Zhang, G.; Zheng, S.; Liu, H.; Chen, P. R. Chem. Soc. Rev. 2015, 44, 3405. doi: 10.1039/C4CS00393D
59. [59]
  Chin, J. W.; Santoro, S. W.; Martin, A. B.; King, D. S.; Wang, L.; Schultz, P. G. J. Am. Chem. Soc. 2002, 124, 9026. doi: 10.1021/ja027007w
60. [60]
  Wang, Z. A.; Zeng, Y.; Kurra, Y.; Wang, X.; Tharp, J. M.; Vatansever, E. C.; Hsu, W. W.; Dai, S.; Fang, X.; Liu, W. R. Angew. Chem., Int. Ed. 2017, 56, 212. doi: 10.1002/anie.201609452
61. [61]
  Wu, N.; Deiters, A.; Cropp, T. A.; King, D.; Schultz, P. G. J. Am. Chem. Soc. 2004, 126, 14306. doi: 10.1021/ja040175z
62. [62]
  Zhang, G.; Li, J.; Xie, R.; Fan, X.; Liu, Y.; Zheng, S.; Ge, Y.; Chen, P. R. ACS Cent. Sci. 2016, 2, 325. doi: 10.1021/acscentsci.6b00024
63. [63]
  Spicer, C. D.; Davis, B. G. Nat. Commun. 2014, 5, 1.
64. [64]
  Kamadurai, H. B.; Souphron, J.; Scott, D. C.; Duda, D. M.; Miller, D. J.; Stringer, D.; Piper, R. C.; Schulman, B. A. Mol. Cell 2009, 36, 1095. doi: 10.1016/j.molcel.2009.11.010
65. [65]
  Mali, S. M.; Singh, S. K.; Eid, E.; Brik, A. J. Am. Chem. Soc. 2017, 139, 4971. doi: 10.1021/jacs.7b00089
66. [66]
  Chatterjee, C.; McGinty, R. K.; Fierz, B.; Muir, T. W. Nat. Chem. Biol. 2010, 6, 267. doi: 10.1038/nchembio.315
67. [67]
  Mali, S. M.; Singh, S. K.; Eid, E.; Brik, A. J. Am. Chem. Soc. 2017, 139, 4971. doi: 10.1021/jacs.7b00089
68. [68]
  Li, X.; Fekner, T.; Ottesen, J. J.; Chan, M. K. Angew. Chem., Int. Ed. 2009, 121, 9348. doi: 10.1002/ange.v121:48
69. [69]
  Nguyen, D. P.; Elliott, T.; Holt, M.; Muir, T. W.; Chin, J. W. J. Am. Chem. Soc. 2011, 133(30), 11418. doi: 10.1021/ja203111c
70. [70]
  Virdee, S.; Kapadnis, P. B.; Elliott, T.; Lang, K.; Madrzak, J.; Nguyen, D. P.; Riechmann, L.; Chin, J. W. J. Am. Chem. Soc. 2011, 133, 10708. doi: 10.1021/ja202799r
71. [71]
  Amamoto, Y.; Aoi, Y.; Nagashima, N.; Suto, H.; Yoshidome, D.; Arimura, Y.; Osakabe, A.; Kato, D.; Kurumizaka, H.; Kawashima, S. A. J. Am. Chem. Soc. 2017, 139, 7568. doi: 10.1021/jacs.7b02138
72. [72]
  Chatterjee, C.; McGinty, R. K.; Pellois, J. P.; Muir, T. W. Angew. Chem., Int. Ed. 2007, 119(16), 2872. doi: 10.1002/(ISSN)1521-3757
73. [73]
  Weller, C. E.; Huang, W.; Chatterjee, C. ChemBioChem 2014, 15(9), 1263. doi: 10.1002/cbic.v15.9
74. [74]
  Weller, C. E.; Dhall, A.; Ding, F.; Linares, E.; Whedon, S. D.; Senger, N. A.; Tyson, E. L.; Bagert, J. D.; Li, X.; Augusto, O.; Chatterjee, C. Nat. Commun. 2016, 7, 12979. doi: 10.1038/ncomms12979
75. [75]
  Wu, J.; Ruiz-Rodríguez, J.; Comstock, J. M.; Dong, J. Z.; Bode, J. W. Chem. Sci. 2011, 2, 1976. doi: 10.1039/c1sc00398d
76. [76]
  Noda, H.; Erös, G. b.; Bode, J. W. J. Am. Chem. Soc. 2014, 136, 5611. doi: 10.1021/ja5018442
77. [77]
  Wan, W.; Huang, Y.; Wang, Z.; Russell, W. K.; Pai, P. J.; Russell, D. H.; Liu, W. R. Angew. Chem., Int. Ed. 2010, 49, 3211. doi: 10.1002/anie.v49:18
78. [78]
  Jing, H.; Lin, H. Chem. Rev. 2015, 115, 2350. doi: 10.1021/cr500457h
79. [79]
  Du, J.; Zhou, Y.; Su, X.; Yu, J. J.; Khan, S.; Jiang, H.; Kim, J.; Woo, J.; Kim, J. H.; Choi, B. H.; Lin, H. Science 2011, 334, 806. doi: 10.1126/science.1207861
80. [80]
  Weinert, B. T.; Schölz, C.; Wagner, S. A.; Iesmantavicius, V.; Su, D.; Daniel, J. A.; Choudhary, C. Cell Rep. 2013, 4, 842. doi: 10.1016/j.celrep.2013.07.024
81. [81]
  Ngo, J. T.; Schuman, E. M.; Tirrell, D. A. Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 4992. doi: 10.1073/pnas.1216375110
82. [82]
  Mahdavi, A.; Segall-Shapiro, T. H.; Kou, S.; Jindal, G. A.; Hoff, K. G.; Liu, S.; Chitsaz, M.; Ismagilov, R. F.; Silberg, J. J.; Tirrell, D. A. J. Am. Chem. Soc. 2013, 135(8), 2979.
83. [83]
  Yang, R.; Bi, X.; Li, F.; Cao, Y.; Liu, C.-F. Chem. Commun. 2014, 50, 7971. doi: 10.1039/C4CC03721A
84. [84]
  Gong, Y.; Pan, L. Tetrahedron Lett. 2015, 56, 2123. doi: 10.1016/j.tetlet.2015.03.065
85. [85]
  Huang, H.; Lin, S.; Garcia, B. A.; Zhao, Y. Chem. Rev. 2015, 115, 2376. doi: 10.1021/cr500491u
86. [86]
  Pattabiraman, V. R.; Bode, J. W. Nature 2011, 480, 471. doi: 10.1038/nature10702
87. [87]
  Fang, X.; Fu, Y.; Long, M. J. C.; Haegele, J. A.; Ge, E. J.; Parvez, S.; Aye, Y. J. Am. Chem. Soc. 2013, 135, 14496. doi: 10.1021/ja405400k
88. [88]
  Wang, L. New Biotechnol. 2017, 38, 16. doi: 10.1016/j.nbt.2016.10.003
89. [89]
  Wan, W.; Tharp, J. M.; Liu, W. R. Biochim. Biophys. Acta, Proteins Proteomics 2014, 1844, 1059. doi: 10.1016/j.bbapap.2014.03.002
90. [90]
  Müller, M. M.; Muir, T. W. Chem. Rev. 2014, 115, 2296.
91. [91]
  Cigler, M.; Müller, T. G.; Horn-Ghetko, D.; von Wrisberg, M. K.; Fottner, M.; Goody, R. S.; Itzen, A.; Müller, M. P.; Lang, K. Angew. Chem., Int. Ed. 2017, 56, 15737. doi: 10.1002/anie.v56.49
92. [92]
  Hoppmann, C.; Wong, A.; Yang, B.; Li, S.; Hunter, T.; Shokat, K. M.; Wang, L. Nat. Chem. Biol. 2017, 13, 842. doi: 10.1038/nchembio.2406
93. [93]
  Wang, Z. A.; Feng, T. S.; Cui, L. J.; Shi, Y. J.; Sha, Y. W. Sci. China:Life Sci. 2013, 43, 778(in Chinese).
94. [94]
  Pan, M.; Gao, S.; Zheng, Y.; Tan, X.; Lan, H.; Tan, X.; Sun, D.; Lu, L.; Wang, T.; Zheng, Q.; Liu, L. J. Am. Chem. Soc. 2016, 138, 7429. doi: 10.1021/jacs.6b04031
95. [95]
  Wang, Z.; Xu, W.; Liu, L.; Zhu, T. F. Nat. Chem. 2016, 8, 698. doi: 10.1038/nchem.2517
1. [1]
  Xinyi Hong , Tailing Xue , Zhou Xu , Enrong Xie , Mingkai Wu , Qingqing Wang , Lina Wu . Non-Site-Specific Fluorescent Labeling of Proteins as a Chemical Biology Experiment. University Chemistry, 2024, 39(4): 351-360. doi: 10.3866/PKU.DXHX202310010
2. [2]
  Hong CAI , Jiewen WU , Jingyun LI , Lixian CHEN , Siqi XIAO , Dan LI . Synthesis of a zinc-cobalt bimetallic adenine metal-organic framework for the recognition of sulfur-containing amino acids. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 114-122. doi: 10.11862/CJIC.20240382
3. [3]
  Zihan Lin , Wanzhen Lin , Fa-Jie Chen . Electrochemical Modifications of Native Peptides. University Chemistry, 2025, 40(3): 318-327. doi: 10.12461/PKU.DXHX202406089
4. [4]
  Ruiying WANG , Hui WANG , Fenglan CHAI , Zhinan ZUO , Benlai WU . Three-dimensional homochiral Eu(Ⅲ) coordination polymer and its amino acid configuration recognition. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 877-884. doi: 10.11862/CJIC.20250052
5. [5]
  Yang Liu , Peng Chen , Lei Liu . Chemistry “101 Plan”: Design and Construction of Chemical Biology Textbook. University Chemistry, 2024, 39(10): 45-51. doi: 10.12461/PKU.DXHX202407085
6. [6]
  Tianyu Feng , Guifang Jia , Peng Zou , Jun Huang , Zhanxia Lü , Zhen Gao , Chu Wang . Construction of the Chemistry Biology Experiment Course in the Chemistry “101 Program”. University Chemistry, 2024, 39(10): 69-77. doi: 10.12461/PKU.DXHX202409002
7. [7]
  Lu XU , Chengyu ZHANG , Wenjuan JI , Haiying YANG , Yunlong FU . Zinc metal-organic framework with high-density free carboxyl oxygen functionalized pore walls for targeted electrochemical sensing of paracetamol. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 907-918. doi: 10.11862/CJIC.20230431
8. [8]
  Tianlong Zhang , Rongling Zhang , Hongsheng Tang , Yan Li , Hua Li . Online Monitoring and Mechanistic Analysis of 3,5-diamino-1,2,4-triazole (DAT) Synthesis via Raman Spectroscopy: A Recommendation for a Comprehensive Instrumental Analysis Experiment. University Chemistry, 2024, 39(6): 303-311. doi: 10.3866/PKU.DXHX202312006
9. [9]
  Yongjie ZHANG , Bintong HUANG , Yueming ZHAI . Research progress of formation mechanism and characterization techniques of protein corona on the surface of nanoparticles. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2318-2334. doi: 10.11862/CJIC.20240247
10. [10]
  Liangzhen Hu , Li Ni , Ziyi Liu , Xiaohui Zhang , Bo Qin , Yan Xiong . A Green Chemistry Experiment on Electrochemical Synthesis of Benzophenone. University Chemistry, 2024, 39(6): 350-356. doi: 10.3866/PKU.DXHX202312001
11. [11]
  Renxiu Zhang , Xin Zhao , Yunfei Zhang . Application of Electrochemical Synthesis in the Teaching of Organic Chemistry. University Chemistry, 2025, 40(4): 174-180. doi: 10.12461/PKU.DXHX202406116
12. [12]
  Zeyu XU , Anlei DANG , Bihua DENG , Xiaoxin ZUO , Yu LU , Ping YANG , Wenzhu YIN . Evaluation of the efficacy of graphene oxide quantum dots as an ovalbumin delivery platform and adjuvant for immune enhancement. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1065-1078. doi: 10.11862/CJIC.20240099
13. [13]
  Fei Liu , Dong-Yang Zhao , Kai Sun , Ting-Ting Yu , Xin Wang . Comprehensive Experimental Design for Photochemical Synthesis, Analysis, and Characterization of Seleno-Containing Medium-Sized N-Heterocycles. University Chemistry, 2024, 39(3): 369-375. doi: 10.3866/PKU.DXHX202309047
14. [14]
  Tingting Yu , Si Chen , Lianglong Sun , Tongtong Shi , Kai Sun , Xin Wang . Comprehensive Experimental Design for the Photochemical Synthesis, Analysis, and Characterization of Difluoropyrroles. University Chemistry, 2024, 39(11): 196-203. doi: 10.3866/PKU.DXHX202401022
15. [15]
  Li Jiang , Changzheng Chen , Yang Su , Hao Song , Yanmao Dong , Yan Yuan , Li Li . Electrochemical Synthesis of Polyaniline and Its Anticorrosive Application: Improvement and Innovative Design of the “Chemical Synthesis of Polyaniline” Experiment. University Chemistry, 2024, 39(3): 336-344. doi: 10.3866/PKU.DXHX202309002
16. [16]
  Caixia Lin , Zhaojiang Shi , Yi Yu , Jianfeng Yan , Keyin Ye , Yaofeng Yuan . Ideological and Political Design for the Electrochemical Synthesis of Benzoxathiazine Dioxide Experiment. University Chemistry, 2024, 39(2): 61-66. doi: 10.3866/PKU.DXHX202309005
17. [17]
  Yikai Wang , Xiaolin Jiang , Haoming Song , Nan Wei , Yifan Wang , Xinjun Xu , Cuihong Li , Hao Lu , Yahui Liu , Zhishan Bo . 氰基修饰的苝二酰亚胺衍生物作为膜厚不敏感型阴极界面材料用于高效有机太阳能电池. Acta Physico-Chimica Sinica, 2025, 41(3): 2406007-. doi: 10.3866/PKU.WHXB202406007
18. [18]
  Zhongyan Cao , Shengnan Jin , Yuxia Wang , Yiyi Chen , Xianqiang Kong , Yuanqing Xu . Advances in Highly Selective Reactions Involving Phenol Derivatives as Aryl Radical Precursors. University Chemistry, 2025, 40(4): 245-252. doi: 10.12461/PKU.DXHX202405186
19. [19]
  Qiaowen CHANG , Ke ZHANG , Guangying HUANG , Nuonan LI , Weiping LIU , Fuquan BAI , Caixian YAN , Yangyang FENG , Chuan ZUO . Syntheses, structures, and photo-physical properties of iridium phosphorescent complexes with phenylpyridine derivatives bearing different substituting groups. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 235-244. doi: 10.11862/CJIC.20240311
20. [20]
  Jingzhao Cheng , Shiyu Gao , Bei Cheng , Kai Yang , Wang Wang , Shaowen Cao . 4-氨基-1H-咪唑-5-甲腈修饰供体-受体型氮化碳光催化剂的构建及其高效光催化产氢研究. Acta Physico-Chimica Sinica, 2024, 40(11): 2406026-. doi: 10.3866/PKU.WHXB202406026

Get Citation

PDF

XML

Metrics

PDF Downloads(31)
Abstract views(2725)
HTML views(672)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142