Citation: Sun Moran, Dai Lei, Yang Hua, Liu Hongmin, Yu Dequan. Enantioselective Synthesis of Core Structures of Hydramicromelins A, B and C[J]. Chinese Journal of Organic Chemistry, ;2018, 38(9): 2443-2449. doi: 10.6023/cjoc201802017 shu

Enantioselective Synthesis of Core Structures of Hydramicromelins A, B and C

Sun Moran ^a,b ,
Dai Lei ^a,b ,
Yang Hua ^a,b,, ,
Liu Hongmin ^a,b,, ,
Yu Dequan ^a

a.
School of Pharmaceutical Science, Zhengzhou University, Zhengzhou 450001
b.
Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou 450001

Corresponding author: Yang Hua, yanghua@zzu.edu.c Liu Hongmin, liuhm@zzu.edu.cn
Received Date: 9 February 2018
Revised Date: 28 March 2018
Available Online: 27 September 2018
Fund Project: the National Natural Science Foundation of China 21302175the National Natural Science Foundation of China 21372205Project supported by the National Natural Science Foundation of China (Nos. 21372205, 21302175) and the Basic Research Project of Science and Technology Department of Henan Province (No. 132300410028)the Basic Research Project of Science and Technology Department of Henan Province 132300410028

Figures(5)

Hydramicromelins A~C are coumarin compounds with unique chemical structure and biological activity. With[2,3]-Meisenheimer rearrangemen as a key reaction which has been developed in our laboratory, the core structures of Hydramicromelin A, B and C were synthesized from L-phenylglycine. The route included Wittig reaction, [2,3]-Meisenheimer rearrangement, epoxidation and dihydroxylation reaction, and it was high-yield and high-enantioselectivity.
- hydramicromelins A, B and C,
- [2, 3]-Meisenheimer rearrangement,
- chiral tertiary alcohol,
- epoxidation
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