Citation: Dai Hong, Ding Ying, Du Xianchao, Yao Wei, Chen Qingwen, Wang Xianglong, Zhong Sulin, Cao Xiongfei, Shi Yujun. Synthesis and Biological Activities of Novel Pyrazole Oximes Containing Substituted Oxadiazole Moiety[J]. Chinese Journal of Organic Chemistry, ;2018, 38(7): 1755-1762. doi: 10.6023/cjoc201802015 shu

Synthesis and Biological Activities of Novel Pyrazole Oximes Containing Substituted Oxadiazole Moiety

a.
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019
b.
United Nations Nantong Pesticide Forulation Development Centre, Nantong 226006

Corresponding author: Shi Yujun, yjshi2015@163.com
Received Date: 8 February 2018
Revised Date: 1 March 2018
Available Online: 29 July 2018
Fund Project: Project supported by the Science and Technology Project Fund of Nantong City (No. MS22015020) and the Science and Technology Innovation Foundation for the College Students of Jiangsu Province (No. 201710304048)the Science and Technology Innovation Foundation for the College Students of Jiangsu Province 201710304048the Science and Technology Project Fund of Nantong City MS22015020

Figures(3)

In order to find novel pyrazole oximes with good bioactivities, a series of novel pyrazole oxime derivatives containing substituted oxadiazole moiety were designed and synthesized according to the method of active substructure combination. Their structures were confirmed by ¹H NMR, ¹³C NMR and elemental analysis. Preliminary bioassay data indicated that some title compounds showed good insecticidal activities. At the concentration of 500 μg/mL, 9 compounds possessed insecticidal activity against Oriental armyworm with 80%~100%. When the concentration was lowered to 100 μg/mL, 3 compounds still displayed significant insecticidal activity against Oriental armyworm with 70%, 60% and 70%. Additionally, one compound had 60% insecticidal activity against Aphis medicaginis at 500 μg/mL.
- oxadiazole,
- pyrazole oxime,
- synthesis,
- biological activity
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1.
沈阳化工大学材料科学与工程学院沈阳 110142