Citation: Cui Penglei, Liu Na, Chen Hua, Li Xiaoliu. Synthesis and Antibacterial Activity Evaluation of the Thiouracil Derivatives Containing Benzothiazole[J]. Chinese Journal of Organic Chemistry, ;2018, 38(10): 2784-2790. doi: 10.6023/cjoc201801040 shu

Synthesis and Antibacterial Activity Evaluation of the Thiouracil Derivatives Containing Benzothiazole

Cui Penglei ^a,b ,
Liu Na ^a ,
Chen Hua ^a,, ,
Li Xiaoliu ^a,,

a.
Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002
b.
College of Science, Agricultural University of Hebei, Baoding 071001

Corresponding author: Chen Hua, hua-todd@163.com Li Xiaoliu,
Received Date: 27 January 2018
Revised Date: 19 March 2018
Available Online: 1 October 2018
Fund Project: the Science and Technology Fund of Agricultural University of Hebei LG20150503Project supported by the Science and Technology Fund of Agricultural University of Hebei (No. LG20150503)

Figures(2)

A series of unreported thiouracil derivatives 7 containing a benzothiazole moiety were synthesized by the reaction of 4-oxo-6-phenyl-2-thioxo-1, 2, 3, 4-tetrahydro-pyrimidine-5-carbonitrile (6) with N-(benzo[d]thiazol-2-yl)-4-(chloromethyl)-benzamide (5), which was prepared from the amidation of 2-aminobenzothiazole and 4-(chloromethyl)benzoyl chloride. The newly synthesized compounds 7 were characterized by IR, MS, NMR, and element analysis. All the compounds were evaluated for their antibacterial activities against Bacillus amyloliquefaciens, Staphylococcus aureus and Bacillus subtilis. The results of the 24-hour antibacterial test showed that some compounds had good inhibitory activities against the three tested strains.
- thiouracil,
- benzothiazole,
- antibacterial activity
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