Citation: Wang Jingjing, Li Feng, Xu Yan, Wang Juan, Wu Ziyan, Yang Chengyu, Liu Lantao. Catalytic Nucleophilic Addition of 3, 5-Dialkyl-4-nitroisoxazoles to Trifluoromethyl Ketones on Water[J]. Chinese Journal of Organic Chemistry, ;2018, 38(5): 1155-1164. doi: 10.6023/cjoc201709049 shu

Catalytic Nucleophilic Addition of 3, 5-Dialkyl-4-nitroisoxazoles to Trifluoromethyl Ketones on Water

Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals, School of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000

Corresponding author: Wang Jingjing, wangjingjing0918@163.com Liu Lantao, liult05@iccas.ac.cn
Received Date: 29 September 2017
Revised Date: 29 December 2017
Available Online: 10 May 2018
Fund Project: the National Natural Sciences Foundation of China 21572126the Key Science Research of Education Committee in Henan Province 15A150072the Key Scientific and Technological Project of Henan Province 172102210099the National Natural Sciences Foundation of China 21402116Project supported by the National Natural Sciences Foundation of China (Nos. 21402116, 21502111, 21572126), the Key Scientific and Technological Project of Henan Province (No. 172102210099) and the Key Science Research of Education Committee in Henan Province (No. 15A150072)the National Natural Sciences Foundation of China 21502111

Figures(3)

The triethylamine catalyzed nucleophilic addition of 3, 5-dialkyl-4-nitroisoxazoles to trifluoromethyl ketones on water has been realized affording trifluoromethyl tertiary alcohol derivatives in 66%~99% yields. The products were easily transformed to the resulting alkenes by dehydration or acids by oxidation.
- on water,
- nucleophilic addition,
- 3, 5-dialkyl-4-nitroisoxazoles,
- trifluoromethyl ketones References
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