Citation: Yan Jun, Ji Xiaoyue, Hua Shugui, Wang Jing. Recent Advances of α-Aryl Vinyl Azides in Nitrogen Heterocycle Synthesis[J]. Chinese Journal of Organic Chemistry, ;2018, 38(4): 791-801. doi: 10.6023/cjoc201709025 shu

Recent Advances of α-Aryl Vinyl Azides in Nitrogen Heterocycle Synthesis

Yan Jun ^a ,
Ji Xiaoyue ^b ,
Hua Shugui ^a,, ,
Wang Jing ^a

a.
Key Construction Laboratory of Bio-functional Molecular of Jiangsu Province, Life Science and Chemistry College, Jiangsu Second Normal University, Nanjing 210013
b.
Advanced Analysis & Testing Center, Nanjing Forestry University, Nanjing 210037

Corresponding author: Hua Shugui, huashugui@jssnu.edu.cn
Received Date: 15 September 2017
Revised Date: 13 October 2017
Available Online: 15 April 2017
Fund Project: the Natural Science Foundation of Jiangsu Province BK20130748Project supported by the Natural Science Foundation of Jiangsu Province (No. BK20130748)

Figures(20)

Nitrogen heterocyclic compounds can be found in various natural products, pharmaceutical chemistry and material chemistry. Due to azide group linked to olefins, α-aryl vinyl azide has unique properties, which can act as electrophilic reagents, nucleophilic reagent, or radical acceptor. Diverse reaction pathways of α-aryl vinyl azide provide great opportunities to generate highly reactive intermediates with unusual or unconventional reactivities, making it possible to develop novel reaction. Recently, more and more synthetic chemists used α-aryl vinyl azide as a key three atoms synthon for the construction of diverse structurally complex N-heterocyclic compounds. This review will introduce systematically the reactivities of α-aryl vinyl azide and the developments of the recent application of α-aryl vinyl azide in nitrogen heterocycle synthesis, including mechanism, reaction characteristics and application study, thus it may be helpful for the research on nitrogen heterocycle synthesis.
- α-aryl vinyl azide,
- synthon,
- nitrogen heterocyclic compounds,
- application
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沈阳化工大学材料科学与工程学院沈阳 110142