Citation: Shao Taiming, Li Xiaobao, Qi Cuicui, Chen Guangying, Song Xiaoping, Han Changri, Zheng Caijuan. Chemical Constituents of Isoflavonoids from Roots of Ficus auriculata[J]. Chinese Journal of Organic Chemistry, ;2018, 38(3): 710-714. doi: 10.6023/cjoc201709008 shu

Chemical Constituents of Isoflavonoids from Roots of Ficus auriculata

a.
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571127
b.
Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, School of Chemical and Material Engineering, Hainan Institute of Science and Technology, Haikou 571126

Corresponding author: Song Xiaoping, sxp628@126.com Han Changri, hchr116@126.com
Received Date: 6 September 2017
Revised Date: 12 October 2017
Available Online: 15 March 2017
Fund Project: the Hainan Special Project for Traditional Chinese Medicine Modernization 2015ZY19the National Natural Science Foundation of China 81360478the Youth Foundation of Hainan Institute of Science and Technology HKYZQJ2014-07the Hainan Province Innovation Research Project of Graduate Students Hyb2017-33Key Research and Development Project of Hainan Province ZDYF2016139the International S & T Cooperation Program of China 2014DFA40850the National Natural Science Foundation of China 21362009Project supported by the National Natural Science Foundation of China (Nos. 81360478, 21362009), the International S & T Cooperation Program of China (No. 2014DFA40850), the Hainan Special Project for Traditional Chinese Medicine Modernization (No. 2015ZY19), Key Research and Development Project of Hainan Province (No. ZDYF2016139), the Natural Science Foundation of Hainan Province (No. 217177), the Youth Foundation of Hainan Institute of Science and Technology (No. HKYZQJ2014-07), the Hainan Province Innovation Research Project of Graduate Students (No. Hyb2017-33)the Natural Science Foundation of Hainan Province 217177

Figures(2)

Five isoflavonoids were isolated from the roots of the Ficus auriculata by means of silica gel column, HPLC and other chromatography methods. By using spectroscopic techniques including NMR, IR and UV, their structures were identified as 5, 7, 4'-trihydroxy-8-(1-hydroxy-2, 3-epoxy-3-methylbutyl)isoflavone (1), 5, 7, 4'-trihydroxy-3'-(2, 6, 7-trihydroxy-3-methylene-7-methyloctyl)isoflavone (2), 5, 7, 4'-trihydroxy-6-[(S)-2, 3-dihydroxy-3-methylbutyl]isoflavone (3), 5, 7, 4'-trihydroxy-6-pre-nylisoflavone (4), and 5, 7, 4'-trihydroxy-3'-prenylisoflavone (5). Compounds 1 and 2 were new isoflavonoids. All compounds were evaluated for their anti osteoporosis activities in vitro. Compounds 4 and 5 showed moderate proliferation function of primary osteoblasts in 100 μmol/L.
- Ficus auriculata,
- chemical constituent,
- isoflavone,
- anti osteoporosis activity
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沈阳化工大学材料科学与工程学院沈阳 110142