Citation: Wang Tao, Xu Kai, Zhang An'an, Wang Wanli, Liu Lantao. Buchwald-Hartwig Amination of Aryl Chlorides Catalyzed by Trinuclear N-Heterocyclic Carbene-Palladium(Ⅱ) Complexes[J]. Chinese Journal of Organic Chemistry, ;2018, 38(1): 259-265. doi: 10.6023/cjoc201708036 shu

Buchwald-Hartwig Amination of Aryl Chlorides Catalyzed by Trinuclear N-Heterocyclic Carbene-Palladium(Ⅱ) Complexes

Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals, School of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000

Corresponding author: Wang Tao, wt67751726@126.com Liu Lantao, liult05@iccas.ac.cn
Received Date: 18 August 2017
Revised Date: 5 October 2017
Available Online: 16 January 2017
Fund Project: Innovation Scientists and Technicians Troop Construction Projects of Henan Province, and Key Scientific and Technological Project of Henan Province 152102410056the National Natural Sciences Foundation of China 21202095the Program for Science & Technology Innovation Talents in Universities of Henan Province 14HASTIT016the National Natural Sciences Foundation of China 21572126the National Natural Sciences Foundation of China U1404205Project supported by the National Natural Sciences Foundation of China (Nos. U1404205, 21572126 and 21202095), the Program for Science & Technology Innovation Talents in Universities of Henan Province (No. 14HASTIT016), Innovation Scientists and Technicians Troop Construction Projects of Henan Province, and Key Scientific and Technological Project of Henan Province (152102410056)

Figures(2)

The trinuclear N-heterocyclic carbene-palladium(Ⅱ) complexes were found to be the effective catalyst precursors for the Buchwald-Hartwig amination of aryl chlorides. With catalyst loading of 2.0 mol%, the amination of secondary and primary amines with a variety of electronically and structurally diverse aryl chlorides gave the desired products in moderate to excellent yields within hours.
- N-heterocyclic carbene,
- trinuclear palladium complexes,
- Buchwald-Hartwig amination,
- aryl chlorides
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