Citation: Dai Hong, Yao Wei, Du Xianchao, Wang Xianglong, Wu Jinming, Chen Qingwen, Li Chunjian, Shi Jian, Zhang Haijun. Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing Substituted Tetrazolyl Group[J]. Chinese Journal of Organic Chemistry, ;2017, 37(12): 3267-3273. doi: 10.6023/cjoc201708026 shu

Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing Substituted Tetrazolyl Group

Dai Hong ^a ,
Yao Wei ^a ,
Du Xianchao ^a ,
Wang Xianglong ^a ,
Wu Jinming ^a,, ,
Chen Qingwen ^a ,
Li Chunjian ^b ,
Shi Jian ^b ,
Zhang Haijun ^a,,

a.
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019
b.
Analysis and Testing Center, Nantong University, Nantong 226019

Corresponding author: Wu Jinming, ntgao2016@163.com Zhang Haijun, hjzh1893@163.com
Received Date: 13 August 2017
Revised Date: 6 September 2017
Available Online: 22 December 2017
Fund Project: Postgraduate Research and Practice Innovation Program of Jiangsu Province SJCX17_0640the Research Foundation of the Six People Peak of Jiangsu Province 2013-SWYY-013Project supported by the National Natural Science Foundation of China (No. 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No. 2013-SWYY-013), and Postgraduate Research and Practice Innovation Program of Jiangsu Province (No. SJCX17_0640)the National Natural Science Foundation of China 21372135

Figures(2)

In order to explore novel pyrazole oxime derivatives with potent biological activities, a series of novel pyrazole oximes carrying tetrazole unit were designed and synthesized by the method of active substructure combination. The structures of the title compounds were confirmed by ¹H NMR, ¹³C NMR, and elemental analysis. Preliminary bioassay data showed that some aimed compounds displayed good insecticidal activities. At the concentration of 500 μg/mL, ten compounds exhibited insecticidal activity against Oriental armyworm with 90%~100%, nine compounds had insecticidal activity against Aphis medicaginis with 80%~100%, ten compounds possessed insecticidal activity against Nilaparvata lugens with 80%~100%, and one compound exhibited 80% acaricidal activity against Tetranychus cinnabarinus. When the concentration was reduced to 100 μg/mL, one compound still showed insecticidal activity against Aphis medicaginis with 85%. Additionally, some compounds had certain fungicidal activity, at 200 μg/mL two compounds showed 60%~80% fungicidal activity against Pseudoperonospora cubensis.
- tetrazole,
- pyrazole oxime,
- synthesis,
- biological activity
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