Citation: Li Minghui, Song Buer, Imerhasan, Mukhtar. Progress in Synthesis and Bioactivity of Spiroisoxazoline Compounds[J]. Chinese Journal of Organic Chemistry, ;2018, 38(2): 378-400. doi: 10.6023/cjoc201708013 shu

Progress in Synthesis and Bioactivity of Spiroisoxazoline Compounds

College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046

Corresponding author: Imerhasan, Mukhtar, imerhasan@xju.edu.cn
Received Date: 8 August 2017
Revised Date: 12 September 2017
Available Online: 19 February 2017
Fund Project: Project supported by the National Natural Science Foundation of China (Nos. 21462043, 21062019)the National Natural Science Foundation of China 21462043the National Natural Science Foundation of China 21062019

Figures(52)

Spiroisoxazoline compounds have so extensive biological activity that they are important drug intermediates, and they are also important organic synthetic intermediates. The relevant reports for forty years are reviewed in this paper. On the basis of reaction mechanisms, the synthetic methods of spiroisoxazoline compounds are classified into the following five types:oxidation, intramolecular condensation, nucleophilic addition, 1, 3-dipolar cycloaddition, and other methods. Among them, the most widely used method is 1, 3-dipolar cycloadditio. This method is of simple operation, high yield and good stereoselectivity, but one of its synthons-carbon dipolarophiles is not easy to get, and generally goes through many steps of reaction to prepare. In addition, their biological activities are summarized as six categories:the activity of inhibiting the growth of the larvae, the activity of slowing hardening of the arteries, the activity for the treatment of pain, the activity of lowering blood sugar, the anticancer activity and the antibacterial activity.
- spiroisoxazoline,
- synthetic method,
- biological activity
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