Citation: Hong Yu, Dai Hong, Ye Linyu, Zhong Sulin, Cao Xiongfei, Shi Yujun, Li Chunjian, Shi Jian, Shi Lei. Synthesis and Insecticidal Activities of Novel Pyrazole Amides Containing Heptafluoroisopropyl Moiety[J]. Chinese Journal of Organic Chemistry, ;2017, 37(11): 3006-3012. doi: 10.6023/cjoc201707022 shu

Synthesis and Insecticidal Activities of Novel Pyrazole Amides Containing Heptafluoroisopropyl Moiety

Hong Yu ^a ,
Dai Hong ^a,, ,
Ye Linyu ^a ,
Zhong Sulin ^b ,
Cao Xiongfei ^b ,
Shi Yujun ^a,, ,
Li Chunjian ^c ,
Shi Jian ^c ,
Shi Lei ^a

a.
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019
b.
United Nations Nantong Pesticide Forulation Development Centre, Nantong 226006
c.
Analysis and Testing Center, Nantong University, Nantong 226019

Corresponding author: Dai Hong, ntgao2016@163.com Shi Yujun, yjshi2015@163.com
Received Date: 20 July 2017
Revised Date: 15 August 2017
Available Online: 18 November 2017
Fund Project: the Science and Technology Innovation Foundation for the Graduate Students of Nantong University YKC16086Project supported by the National Natural Science Foundation of China (No. 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No. 2013-SWYY-013), the Science and Technology Project Fund of Nantong City (No. MS22015020), the Science and Technology Innovation Foundation for the College Students of Jiangsu Province (No. 201610304047Z) and the Science and Technology Innovation Foundation for the Graduate Students of Nantong University (No. YKC16086)the Science and Technology Project Fund of Nantong City MS22015020the Science and Technology Innovation Foundation for the College Students of Jiangsu Province 201610304047Zthe National Natural Science Foundation of China 21372135the Research Foundation of the Six People Peak of Jiangsu Province 2013-SWYY-013

Figures(2)

In order to find new pyrazole derivatives with potent biological activities, a series of novel pyrazole amides containing heptafluoroisopropyl moiety were prepared according to the method of active substructure combination. Their structures were characterized by ¹H NMR, ¹³C NMR and elemental analysis. Preliminary bioassay data showed that some target compounds displayed good insecticidal activities. At the concentration of 500 μg/mL, eleven compounds had insecticidal activity against Oriental armyworm of 60%~100%. When the concentration was reduced to 100 μg/mL, three compounds showed insecticidal activity against Oriental armyworm of 60%~70%, better than that of the control tolfenpyrad.
- heptafluoroisopropyl,
- pyrazole,
- synthesis,
- insecticidal activity
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