Citation: Cen Jinghe, Yang Kai, Li Jianxiao, Li Can, Yang Shaorong. Direct 3-Arylsulfenylation of Indoles with Thiols in Basic Ionic Liquid[J]. Chinese Journal of Organic Chemistry, ;2017, 37(12): 3213-3219. doi: 10.6023/cjoc201707005 shu

Direct 3-Arylsulfenylation of Indoles with Thiols in Basic Ionic Liquid

Cen Jinghe ^a,, ,
Yang Kai ^b,, ,
Li Jianxiao ^a,, ,
Li Can ^a ,
Yang Shaorong ^a,,

a.
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640
b.
School of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000

Corresponding author: Cen Jinghe, Yang Kai, Li Jianxiao, cejxli@scut.edu.cn Yang Shaorong, lisryang@scut.edu.cn
Received Date: 5 July 2017
Revised Date: 16 August 2017
Available Online: 18 December 2017
Fund Project: the National Natural Science Foundation of China 21502055the China Postdoctoral Science Foundation 2016T90779the National Natural Science Foundation of China 21502055Project supported by the National Natural Science Foundation of China (Nos. 21502055, 21642005), the Fundamental Research Funds for the Central Universities (No. 2015ZM150) and the China Postdoctoral Science Foundation (No. 2016T90779)the Fundamental Research Funds for the Central Universities 2015ZM150

An efficient and convenient transition metal-free procedure for the synthesis of 3-sulfenylindoles derivatives in moderate to good yields from readily available indoles and thiols in basic ionic liquid has been developed. Their structures were confirmed by ¹H NMR, ¹³C NMR and HRMS. This sulfenylation process provides a novel route for directly accessing 3-sulfenylindoles in good to excellent yields and good functional group tolerance with high atom efficiency. Notably, the current methodology could also be conveniently applied to the synthesis of thioarylated naturally occurring biologically active frameworks.
- ionic liquids,
- indoles,
- thiols,
- 3-arylsulfenylation reaction
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