Citation: Luo Dayun, Hu Xingmei, Zi Quanxing, Lin Jun, Yan Shengjiao. Green Synthesis of Indanone Fused Pyrrole Compounds[J]. Chinese Journal of Organic Chemistry, ;2017, 37(12): 3204-3212. doi: 10.6023/cjoc201706002 shu

Green Synthesis of Indanone Fused Pyrrole Compounds

Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091

Corresponding author: Lin Jun, linjun@ynu.edu.cn Yan Shengjiao, yansj@ynu.edu.cn
Received Date: 1 June 2017
Revised Date: 5 July 2017
Available Online: 18 December 2017
Fund Project: the National Natural Science Foundation of China 21262042the Natural Science Foundation of Yunnan Province 2017FA003the Talent Found in Yunnan Province 2012HB001the National Natural Science Foundation of China U1202221the National Natural Science Foundation of China 21362042the National Natural Science Foundation of China 21662042Project supported by the National Natural Science Foundation of China (Nos. 21362042, 21662042, U1202221, 21262042), the Natural Science Foundation of Yunnan Province (No. 2017FA003), the Talent Found in Yunnan Province (No. 2012HB001), the Donglu Scholar of Yunnan University and the Excellent Young Talents in Yunnan University

Figures(3)

green synthetic method was constructed for the synthesis of indanone fused pyrrolone compounds, which based on the catalyst-free reaction of N-alkyl-1-methylthio-2-nitroethenamine (1) with ninhydrin hydrate (2) in ethanol at reflux. As a result, a series of indanone fused pyrrolones have been synthesized with 91%~98% yields by this one-step reaction. This protocol possesses some advantages including readily available starting materials, simple operation and concise synthetic route and so on.
- N-alkyl-1-methylthio-2-nitroethenamine,
- ninhydrin,
- indanone,
- pyrrole,
- green synthesis
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