Citation: Xu Haizhen, Xie Lifen, Han Tingfeng, He Jingli, Zhu Youquan. Synthesis, Herbicidal Activities of Novel Triketone Compounds Containing 4-Substituted Cyclopentane-1, 3-dione Moiety[J]. Chinese Journal of Organic Chemistry, ;2017, 37(10): 2717-2724. doi: 10.6023/cjoc201704039 shu

Synthesis, Herbicidal Activities of Novel Triketone Compounds Containing 4-Substituted Cyclopentane-1, 3-dione Moiety

Xu Haizhen ^a,, ,
Xie Lifen ^b ,
Han Tingfeng ^b ,
He Jingli ^b ,
Zhu Youquan ^b,,

a.
College of Chemistry, Tianjin Normal University, Tianjin 300387
b.
State Key Laboratory of Elemento-organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071

Corresponding author: Xu Haizhen, hxxyxhz@mail.tjnu.edu.cn Zhu Youquan, zyq8165@nankai.edu.cn
Received Date: 24 April 2017
Revised Date: 10 May 2017
Available Online: 7 October 2017
Fund Project: the National Natural Science Foundation of China 21072108Project supported by the National Natural Science Foundation of China (Nos. 21072108, 21372134)the National Natural Science Foundation of China 21372134

Figures(4)

To find new lead compounds with muti-bioactivities, a series of novel triketone derivatives containing 4-substituted cyclopentane-1, 3-dione were designed on the base of various commercial products. The target compounds were synthesized from cyclopentane-1, 3-dione in six steps. Their structures were confirmed by IR, ¹H NMR spectra and HRMS. The preliminary greenhouse bioassay results indicated that some compounds showed obvious inhibition effects against Brassica campestris, and the inhibition rate was more than 80% at 100 μg/mL. In the pre-and post-emergence, some of them exhibited excellent herbicidal activities against Brassica campestris, and the herbicidal activity was more than 90% at 1500 g/ha.
- triketone,
- 4-substituted cyclopentane-1, 3-dione,
- synthesis,
- herbicidal activity
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