Citation: Dai Hong, Ye Linyu, Li Yang, Fang Yuan, Shi Yujun, Liang Zhipeng, Shi Jian. Synthesis and Biological Activities of Novel Pyrazole Oximes Containing Substituted Pyrimidine Group[J]. Chinese Journal of Organic Chemistry, ;2017, 37(4): 1020-1026. doi: 10.6023/cjoc201611042 shu

Synthesis and Biological Activities of Novel Pyrazole Oximes Containing Substituted Pyrimidine Group

Dai Hong ^a ,
Ye Linyu ^a ,
Li Yang ^b ,
Fang Yuan ^b ,
Shi Yujun ^a,b,*,, ,
Liang Zhipeng ^c ,
Shi Jian ^c,*,,

a.
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019
b.
School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003
c.
Analysis and Testing Center, Nantong University, Nantong 226019

Corresponding author: Shi Yujun, yjshi2015@163.com Shi Jian, gaohbhe2015@aliyun.com
Received Date: 30 November 2016
Revised Date: 4 January 2017

Fund Project: the Research Foundation of the Six People Peak of Jiangsu Province 2013-SWYY-013the National Natural Science Foundation of China 21372135the Science and Technology Innovation Foundation for the Graduate Students of Nantong University YKC16086

Figures(3)

In order to explore novel potent pesticide from pyrazole oxime derivatives, a series of new pyrazole oxime compounds carrying substituted pyrimidine moiety were synthesized by the method of active substructure combination. The structures of the title compounds were characterized by ¹H NMR, ¹³C NMR, MS and elemental analysis. Preliminary bioassay data displayed that some target compounds showed certain insecticidal activities. At the concentration of 500 μg/mL, compounds 6b and 6c exhibited 60% and 70% insecticidal activity against Aphis craccivora, compounds 6a, 6b, 6c, and 6d had 100%, 100%, 100% and 90% insecticidal activity against Nilaparvata lugens. When the concentration was reduced to 100 μg/mL, compounds 6a, 6b and 6d were still active against Nilaparvata lugens with inhibitory values of 60%, 60% and 50%, respectively. In addition, insecticidal activities against Oriental armyworm of compounds 6f, 6g and 6m were 80%, 70% and 90%, respectively, at 500 μg/mL.
- pyrimidine,
- pyrazole oxime,
- synthesis,
- bioactivity
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