Citation: Wang Yonggang, Liu Renrong, Gao Jianrong, Jia Yixia. Palladium-Catalyzed Dearomative Decarboxylative Alkynylation of Indoles with Acetylenecarboxylic Acids[J]. Chinese Journal of Organic Chemistry, ;2017, 37(3): 691-697. doi: 10.6023/cjoc201608027 shu

Palladium-Catalyzed Dearomative Decarboxylative Alkynylation of Indoles with Acetylenecarboxylic Acids

College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014

Corresponding author: Jia Yixia, yxjia@zjut.edu.cn
Received Date: 26 August 2016
Revised Date: 15 November 2016

Fund Project: the National Natural Science Foundation of China 21372202the National Natural Science Foundation of China 21522207

Figures(1)

A palladium-catalyzed indole dearomative arylalkynylation via decarboxylative coupling of alkynyl carboxylic acids and alkyl-palladium intermediates has been developed, which provides a reliable approach to a serious of structural diversely 2, 3-disubstituted indolines bearing vicinal tertiary and quaternary stereocenters in moderate to good yields and excellent diastereoselectivities.
- homogenous catalysis,
- palladium,
- indole,
- dearomatization,
- alkynylation
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