Citation: Zhou Zongbao, Wang Hong, Tao Kaiqi, Ye Xiaochuan, Hu Chunling. A Facile Method to Prepare Dihydroflavonol Derivatives[J]. Chinese Journal of Organic Chemistry, ;2016, 36(11): 2752-2756. doi: 10.6023/cjoc201605044 shu

A Facile Method to Prepare Dihydroflavonol Derivatives

1.
Key Laboratory of Chinese Medicine Chemistry and Chinese Herbal Compound of Hubei Province, College of Pharmacy, Hubei University of Traditional Chinese Medicine, Wuhan 430065

Corresponding author: Hu Chunling, 1054681196@qq.com
Received Date: 30 May 2016
Revised Date: 25 June 2016

Fund Project: National Natural Science Foundation of China 31370378

Figures(1)

A series of dihydroflavonol derivatives were synthesized by the reaction of 2'-hydroxyl chalcone derivatives with H₂O₂/(CH₃CH₂)₂NH system in anhydrous tetrahydrofuran under low temperature. The influences of reaction temperature, re-action solvents, the kinds and proportion of alkaline additive and oxidants on this reaction were investigated, and the optimal reaction conditions were determined. This method has the advantages of simple operation, mild conditions and convenient post-treatment. Besides, all synthetic products were fully characterized by NMR spectra.
- 2'-hydroxyl chalcone derivatives,
- dihydroflavonol derivatives,
- facile method
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沈阳化工大学材料科学与工程学院沈阳 110142