Citation: Lin Yuping, Hu Chunyan, Zheng Xi, Wang Xiuli, Wan Chunping, Mao Zewei. Synthesis and Anti-tumor Activities of Novel 4'-(N-Substitued-1-piperazinyl) chalcone Derivatives[J]. Chinese Journal of Organic Chemistry, ;2017, 37(1): 237-241. doi: 10.6023/cjoc201605021 shu

Synthesis and Anti-tumor Activities of Novel 4'-(N-Substitued-1-piperazinyl) chalcone Derivatives

Lin Yuping ^a ,
Hu Chunyan ^a ,
Zheng Xi ^b ,
Wang Xiuli ^a ,
Wan Chunping ^b ,
Mao Zewei ^a,*,,

a.
School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500
b.
Central Laboratory, The No. 1 Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming 650021

Corresponding author: Mao Zewei, ydmason@163.com
Received Date: 12 May 2016
Revised Date: 20 June 2016

Fund Project: the National Natural Science Foundation of China 81460624the Foundation of Yunnan Province Department of Education 2014Z119

Figures(2)

With the aim of developing new potent anticancer agents, a series of novel 4'-(N-substitued-1-piperazinyl) chalcone derivatives 3a~3j have been designed and synthesized based on the structure of the chalcone by molecular hybridization.The structures were characterized by ¹H NMR, ¹³C NMR and HRMS.These derivatives were evaluated for their in vitro anti-tumor activity against a panel of human tumor cell lines (Hela, A549 and SGC7901) by the thiazolyl blue tetrazolium bromide (MTT) assay.The result indicated that compounds 3f, 3i and 3j were found to be the potent compounds against human tumor cell lines, which are to be lead compounds for further structural modifications and activity research.
- chalcone,
- piperazine,
- synthesis,
- anti-tumor activity
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